These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
In Vivo Models for Golgi Fragmentation and the Molecular Pathogenesis of Alzheimer’s Disease |
2023 $230,000 |
|
Microglial-Specific INPP5D Knockdown Modulates Behavior, Amyloidosis and Tauopathy in Alzheimer’s Mouse Models |
2022 $217,327 |
|
Intersection of Microglial Transcriptomes to Identify Key Alzheimer’s Pathways of Brain Phagocytes |
2016 $150,000 |
|
Stem Cell Approach to Investigating the Phenomenon of Brain Insulin Resistance |
2015 $100,000 |
|
Generation of iPS Cells and Neurons from Skin Fibroblasts from Subjects with Familial and Sporadic AD |
2014 $200,000 |
|
Stem Cell Consortium |
2013 $600,000 |
|
Oligomer Collaborative Projects |
2006 $1,550,000 |
|
ADAM10 and Dimebolin |
2009 $150,000 |
|
Brain Structure, Abeta Metabolism and Behavior in Mice Deficient in Diabetes and Alzheimer’s Associated SorCS1 |
2010 $100,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Jean-Vianney Haure-Mirande, Mickael Audrain, Tomas Fanutza, Soong Ho Kim, William L. Klein, Charles Glabe, Ben Readhead, Joel T. Dudley, Robert D. Blitzer, Minghui Wang, Bin Zhang, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology, Acta Neuropathologica, 134(5), Nov 2017, 769-788, Read More
Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2(N141I) neurons, Acta Neuropathologica Communications, 5, 27 Oct 2017, 77, Read More
Henry H. Ruiz, Tiffany Chi, Andrew C. Shin, Claudia Lindtner, Wilson Hsieh, Michelle Ehrlich, Sam Gandy, Christoph Buettner Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer’s disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels, Alzheimer's & Dementia, 12(8), Aug 2016, 851–861, Read More
Elysse M. Knight, PhD, Soong Ho Kim, PhD, Jessica C. Kottwitz, BS, Asa Hatami, PhD, Ricardo Albay, BS, Akinobu Suzuki, PhD, Alex Lublin, PhD, Cristina M. Alberini, PhD, William L. Klein, PhD, Paul Szabo, PhD, Norman R. Relkin, MD, PhD, Michelle Ehrlich, MD, Charles G. Glabe, PhD, Sam Gandy, MD, PhD and John W. Steele, PhD Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes, Neurol Neuroimmunol Neuroinflamm, 3(3), May 2016, Read More
Dara L. Dickstein, Effie M. Mitsis, Corey Fernandez, Mariel Pullman, Patrick R. Hof, Jennifer Short, Gregory Elder, Barry Jordan, Stephen Ahlers, Heidi Bender, Martin L. Goldstein, John F. Crary, Kristen Dams-O’Connor, Wayne Gordon, Robert Cantu, Karin Knesaurek, Mary Sano, James R. Stone6, Lale Kostakoglu, Steven T. DeKosky, and Sam Gandy Chronic Traumatic Encephalopathy: Diagnosing the Repetitively Injured Brains of Athletes and Soldiers, Current Research: Concussion, December 2015, Download Paper
Joshua G Hunsberger, PhD, Mahendra Rao, MD, Joanne Kurtzberg, MD, Jeff W M Bulte, PhD, Anthony Atala, MD, Frank M LaFerla, PhD, Henry T Greely, JD, Akira Sawa,MD, Sam Gandy, MD, Lon S Schneider, MD, P Murali Doraiswamy, MBBS Accelerating stem cell trials for Alzheimer’s disease, The Lancet Neurology, 15(2), February 2016, 219–230, Read More
Hannah Brautigam, Cesar L. Moreno, John W. Steele, Alexey Bogush, Dara L. Dickstein, John B.J. Kwok, Peter R. Schofield, Gopal Thinakaran, Paul M. Mathews, Patrick R. Hof, Sam Gandy, and Michelle E. Ehrlich Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1−/− phenotype and forms complexes with wildtype PS1 and nicastrin, Scientific Reports, 5, 11/26/2015, 17042, Read More
B Readhead, J-V Haure-Mirande, B Zhang, V Haroutunian, S Gandy, EE Schadt, JT Dudley, and ME Ehrlich Molecular systems evaluation of oligomerogenic APPE693Q and fibrillogenic APPKM670/671NL/PSEN1Δexon9 mouse models identifies shared features with human Alzheimer’s brain molecular pathology, Molecular Psychiatry, November 2015, 1-13, Read More
Sam Gandy, Mary Sano Alzheimer disease: Solanezumab—prospects for meaningful interventions in AD?, Nature Reviews Neurology, 11, 03 November 2015, 669–670, Read More
Andrew A. Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Michael W. Nestor, Miriam Navarro-Sobrino, Ismael Santa-Maria, Matthew Zimmer, Soline Aubry, John W. Steele, David J. Kahler, Alex Dranovsky, Ottavio Arancio, John F. Crary, Sam Gandy, and Scott A. Noggle Characterization and Molecular Profiling of PSEN1 Familial Alzheimer’s Disease iPSC-Derived Neural Progenitors, PLoS ONE, 9(1), Jan 8 2014, Read More
J W Steele, M L Lachenmayer, S Ju, A Stock, J Liken, S H Kim, L M Delgado, I E Alfaro, S Bernales, G Verdile, P Bharadwaj, V Gupta, R Barr, A Friss, G Dolios, R Wang, D Ringe, P Fraser, D Westaway, P H St George-Hyslop, P Szabo, N R Relkin, J D Buxbaum, C G Glabe, A A Protter, R N Martins, M E Ehrlich, G A Petsko, Z Yue and S Gandy Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model, Mol Psychiatry, 18(8), Aug 2013, 889-897, Read More
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain, Mol Psychiatry, 18(8), August 2013, 882-888, Read More
Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer’s Amyloid-β Peptide, J Neurosci, 33(16), April 17, 2013, 7099-7107, Read More
Steven T. DeKosky, Kaj Blennow, Milos D. Ikonomovic & Sam Gandy Traumatic Brain Injury (TBI) can lead to Neurodegenerative Syndromes that include Alzheimer Disease (AD) and Chronic Traumatic Encephalopathy (CTE), Nature Reviews Neurology, Volume 9, No 4, April 2013, 192-200, Read More
Steven T. DeKosky, Kaj Blennow, Milos D. Ikonomovic & Sam Gandy Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers, Nature Reviews Neurology, April 2013, 192-200, Read More
Soong Ho Kim1, Elysse M Knight, Eric L Saunders, Azita K Cuevas, Marusia Popovech, Lung-Chi Chen, Sam Gandy Rapid doubling of Alzheimer’s amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution, F1000Research, 1:70, Dec 21, 2012, Read More
Rachel F. Lane, Peter St George-Hyslop, Barbara L. Hempstead, Scott A. Small, Stephen M. Strittmatter, and Sam Gandy Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes, The Journal of Neuroscience, 32(41), October 10, 2012, 14080 –14086, Read More
Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers, Annals of Neurology, Volume 68, Issue 2, August 2010, Read More
Kim SH, Fraser PE, Westaway D, George-Hyslop PH, Ehrlich ME, Gandy S Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer’s Amyloid β42 from Isolated Intact Nerve Terminals, The Journal of Neuroscience, 30(11), Mar 17, 2010, 3870-3875, Read More
Lublin AL, Gandy S Amyloid-β Oligomers: Possible Role as Key Neurotoxins in Alzheimer’s Disease, Mount Sinai Joural of Medicine, 77, January 2010, 43-9, Read More
Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins R, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction, The Journal of Biological Chemistry, 284(52), Dec 25, 2009, 36024-33, Read More
Steele JW, Kim HS, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PSG, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo, Molecular Neurodegeneration, 4:51, Dec 17, 2009, Read More
Kaufer D, Gandy S. APOE ε4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics, Neurology, 73(24), Dec 15, 2009, 2052-3, Read More
Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses, Chemical Biology, 4:8, July 22, 2009, 673-684, Read More