Sam Gandy, M.D., Ph.D.

Dr. Gandy is an international expert in the metabolism of the sticky substance called amyloid that clogs the brain in patients with Alzheimer’s. In 1989, Gandy and his team discovered the first drugs that could lower formation of amyloid. Dr. Gandy has written more than 250 original papers, chapters and reviews on this topic. Dr. Gandy has received continuous NIH funding for his research on amyloid metabolism since 1986. In work that is being prepared for publication and that forms the basis for his nomination to the Cure Alzheimer’s Fund Consortium, Dr. Gandy and his colleague, Dr. Michelle Ehrlich (Professor of Neurology, Pediatrics and Genetics at Mount Sinai School of Medicine) have created a highly novel transgenic mouse that accumulates Aβ oligomers in the brain and develops memory problems but never develops amyloid “plaques” during its entire lifetime.

Dr. Gandy received his M.D. and Ph.D. at the Medical University of South Carolina. He did his postgraduate work at the Columbia University College of Physicians & Surgeons and Cornell University Medical College. Dr. Gandy completed his post doctorate at The Rockefeller University, where he was appointed assistant professor in the laboratory of Paul Greengard, 2000 Laureate of the Nobel Prize in Physiology or Medicine. Gandy was appointed associate professor of neurology and neurosciences at Cornell University Medical College in 1992. In 1997, he moved to New York University where he served as professor of psychiatry and cell biology until his appointment as Paul C. Brucker, M.D., Professor of Neuroscience at Jefferson Medical College and Director of the Farber Institute for Neurosciences in 2001. In July 2007, he assumed his current post as Sinai Professor of Alzheimer’s Disease Research at the Mount Sinai School of Medicine.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Jean-Vianney Haure-Mirande, Mickael Audrain, Tomas Fanutza, Soong Ho Kim, William L. Klein, Charles Glabe, Ben Readhead, Joel T. Dudley, Robert D. Blitzer, Minghui Wang, Bin Zhang, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology, Acta Neuropathologica, 134(5), Nov 2017, 769-788, Read More

Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2(N141I) neurons, Acta Neuropathologica Communications, 5, 27 Oct 2017, 77, Read More

Henry H. Ruiz, Tiffany Chi, Andrew C. Shin, Claudia Lindtner, Wilson Hsieh, Michelle Ehrlich, Sam Gandy, Christoph Buettner Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer’s disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels, Alzheimer's & Dementia, 12(8), Aug 2016, 851–861, Read More

Elysse M. Knight, PhD, Soong Ho Kim, PhD, Jessica C. Kottwitz, BS, Asa Hatami, PhD, Ricardo Albay, BS, Akinobu Suzuki, PhD, Alex Lublin, PhD, Cristina M. Alberini, PhD, William L. Klein, PhD, Paul Szabo, PhD, Norman R. Relkin, MD, PhD, Michelle Ehrlich, MD, Charles G. Glabe, PhD, Sam Gandy, MD, PhD and John W. Steele, PhD Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes, Neurol Neuroimmunol Neuroinflamm, 3(3), May 2016, Read More

Dara L. Dickstein, Effie M. Mitsis, Corey Fernandez, Mariel Pullman, Patrick R. Hof, Jennifer Short, Gregory Elder, Barry Jordan, Stephen Ahlers, Heidi Bender, Martin L. Goldstein, John F. Crary, Kristen Dams-O’Connor, Wayne Gordon, Robert Cantu, Karin Knesaurek, Mary Sano, James R. Stone6, Lale Kostakoglu, Steven T. DeKosky, and Sam Gandy Chronic Traumatic Encephalopathy: Diagnosing the Repetitively Injured Brains of Athletes and Soldiers, Current Research: Concussion, December 2015, Download Paper

Joshua G Hunsberger, PhD, Mahendra Rao, MD, Joanne Kurtzberg, MD, Jeff W M Bulte, PhD, Anthony Atala, MD, Frank M LaFerla, PhD, Henry T Greely, JD, Akira Sawa,MD, Sam Gandy, MD, Lon S Schneider, MD, P Murali Doraiswamy, MBBS Accelerating stem cell trials for Alzheimer’s disease, The Lancet Neurology, 15(2), February 2016, 219–230, Read More

Hannah Brautigam, Cesar L. Moreno, John W. Steele, Alexey Bogush, Dara L. Dickstein, John B.J. Kwok, Peter R. Schofield, Gopal Thinakaran, Paul M. Mathews, Patrick R. Hof, Sam Gandy, and Michelle E. Ehrlich Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1−/− phenotype and forms complexes with wildtype PS1 and nicastrin, Scientific Reports, 5, 2015, 17042, Read More

B Readhead, J-V Haure-Mirande, B Zhang, V Haroutunian, S Gandy, EE Schadt, JT Dudley, and ME Ehrlich Molecular systems evaluation of oligomerogenic APPE693Q and fibrillogenic APPKM670/671NL/PSEN1Δexon9 mouse models identifies shared features with human Alzheimer’s brain molecular pathology, Molecular Psychiatry, November 2015, 1-13, Read More

Sam Gandy, Mary Sano Alzheimer disease: Solanezumab—prospects for meaningful interventions in AD?, Nature Reviews Neurology, 11, 03 November 2015, 669–670, Read More

Andrew A. Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Michael W. Nestor, Miriam Navarro-Sobrino, Ismael Santa-Maria, Matthew Zimmer, Soline Aubry, John W. Steele, David J. Kahler, Alex Dranovsky, Ottavio Arancio, John F. Crary, Sam Gandy, and Scott A. Noggle Characterization and Molecular Profiling of PSEN1 Familial Alzheimer’s Disease iPSC-Derived Neural Progenitors, PLoS ONE, 9(1), Jan 8 2014, Read More

J W Steele, M L Lachenmayer, S Ju, A Stock, J Liken, S H Kim, L M Delgado, I E Alfaro, S Bernales, G Verdile, P Bharadwaj, V Gupta, R Barr, A Friss, G Dolios, R Wang, D Ringe, P Fraser, D Westaway, P H St George-Hyslop, P Szabo, N R Relkin, J D Buxbaum, C G Glabe, A A Protter, R N Martins, M E Ehrlich, G A Petsko, Z Yue and S Gandy Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model, Mol Psychiatry, 18(8), Aug 2013, 889-897, Read More

Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain, Mol Psychiatry, 18(8), August 2013, 882-888, Read More

Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer’s Amyloid-β Peptide, J Neurosci, 33(16), April 17, 2013, 7099-7107, Read More

Steven T. DeKosky, Kaj Blennow, Milos D. Ikonomovic & Sam Gandy Traumatic Brain Injury (TBI) can lead to Neurodegenerative Syndromes that include Alzheimer Disease (AD) and Chronic Traumatic Encephalopathy (CTE), Nature Reviews Neurology, Volume 9, No 4, April 2013, 192-200, Read More

Steven T. DeKosky, Kaj Blennow, Milos D. Ikonomovic & Sam Gandy Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers, Nature Reviews Neurology, April 2013, 192-200, Read More

Soong Ho Kim1, Elysse M Knight, Eric L Saunders, Azita K Cuevas, Marusia Popovech, Lung-Chi Chen, Sam Gandy Rapid doubling of Alzheimer’s amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution, F1000Research, 1:70, Dec 21, 2012, Read More

Rachel F. Lane, Peter St George-Hyslop, Barbara L. Hempstead, Scott A. Small, Stephen M. Strittmatter, and Sam Gandy Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes, The Journal of Neuroscience, 32(41), October 10, 2012, 14080 –14086, Read More

Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers, Annals of Neurology, Volume 68, Issue 2, August 2010, Read More

Kim SH, Fraser PE, Westaway D, George-Hyslop PH, Ehrlich ME, Gandy S Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer’s Amyloid β42 from Isolated Intact Nerve Terminals, The Journal of Neuroscience, 30(11), Mar 17, 2010, 3870-3875, Read More

Lublin AL, Gandy S Amyloid-β Oligomers: Possible Role as Key Neurotoxins in Alzheimer’s Disease, Mount Sinai Joural of Medicine, 77, January 2010, 43-9, Read More

Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins R, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction, The Journal of Biological Chemistry, 284(52), Dec 25, 2009, 36024-33, Read More

Steele JW, Kim HS, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PSG, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo, Molecular Neurodegeneration, 4:51, Dec 17, 2009, Read More

Kaufer D, Gandy S. APOE ε4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics, Neurology, 73(24), Dec 15, 2009, 2052-3, Read More

Novel Pentameric Thiophene Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses, Chemical Biology, 4:8, July 22, 2009, 673-684, Read More