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Costantino Iadecola, M.D.

Director and Chair, Feil Family Brain & Mind Research Institute; Anne Parrish Titzell Professor of Neurology and Neuroscience; Weill Cornell Medical College

Costantino Iadecola, M.D. is the Director and Chair of the Feil Family Brain and Mind Research Institute and the Anne Parrish Titzell Professor of Neurology at Weill Cornell Medical College. His research focuses on the basic mechanisms of neurovascular function and on the cellular and molecular alterations underlying ischemic brain injury, neurodegeneration and other conditions associated with cognitive impairment.

A pioneer in establishing the concept of neurovascular unit, Dr. Iadecola has championed the involvement of neurovascular dysfunction in neurodegenerative diseases, and the role of innate immunity and the microbiome in ischemic brain injury. He has published over 390 papers in peer-reviewed journals and plays a leadership role in research organizations and funding agencies in the US and abroad. He has been involved, as editor or editorial board member, in several journals including Circulation research, Stroke, Hypertension, the Journal of Neuroscience, and the Annals of Neurology. Dr. Iadecola has received the McHenry Award from the American Academy of Neurology, two Jacob Javits Awards from the National Institutes of Health, the Willis Award-the highest honor in stroke research bestowed by the American Heart Association (AHA), the Zenith Fellow Award from the Alzheimer’s Association, the Excellence Award in Hypertension Research (Novartis) from the Hypertension Council of the AHA, and the Chancellor’s Award in Neuroscience from Louisiana State University.  In 2015, he was elected to the Association of American Physicians. In 2018 and 2019, Clarivate Analytics listed Dr. Iadecola as one of world’s “Highly Cited Researchers” for ranking in the top one percent of the most-cited authors in the field of neuroscience and behavioral sciences. In 2019 Dr. Iadecola was elected Distinguished Scientist by the American Heart Association.

 

 

Related Research:

Hypertension, Tau and Neurodegeneration Costantino Iadecola Giuseppe Faraco 2024-06-28 Tau-Induced Postsynaptic Dysfunction in Tauopathy Models Karin Hochrainer Costantino Iadecola 2023-09-19 Gut Microbiota, Endothelial Dysfunction and Tau-Mediated Cognitive Impairment Giuseppe Faraco Costantino Iadecola 2021-01-29 Dietary Salt, Tau Phosphorylation and Cognitive Impairment Giuseppe Faraco Costantino Iadecola 2018-12-18

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Hypertension, Tau and Neurodegeneration 2024, 2025

$401,064
Tau-Induced Postsynaptic Dysfunction in Tauopathy Models 2023, 2024

$402,500
Gut Microbiota, Endothelial Dysfunction and Tau-Mediated Cognitive Impairment 2020, 2022

$345,500
Dietary Salt, Tau Phosphorylation and Cognitive Impairment 2018-2019

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Ahn, S. J., Goya, B., Bertomo, C., Sciortino, R., Racchumi, G., Garcia Bonilla, L., Anrather, J., Iadecola, C., & Faraco, G. Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet, Cardiovascular Research, November 10, 2025, Read More

Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., … Gate, D., … , Iadecola, C., Johnson, L. A., Kanekiyo, T., … Lamb, B.T., … Marcora, E., … Morganti, J. M., … Ramachandran, K. V., … Tsai, L. H., … Ulrich, J. D., van der Kant, R., … Wellington, C. L., … Zhao, N., Bu, G., Goate, A. M., Holtzman, D. M. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference, Alzheimer's & Dementia, July 19, 2024, Read More

Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M., … Zlokovic, B. V. Vascular dysfunction — The disregarded partner of Alzheimer’s disease, Alzheimer's & Dementia, January 1, 2019, Read More

Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J., & Iadecola, C. Dietary salt promotes cognitive impairment through tau phosphorylation, Nature, October 23, 2019, Read More

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