These projects were made possible from Cure Alzheimer's Fund support.
These published papers resulted from Cure Alzheimer’s Fund support.
Lin, P. B., & Holtzman, D. M. Current insights into apolipoprotein E and the immune response in Alzheimer’s disease, Immunological Reviews, October 24, 2024, Read More
Capocchi, J. K., Figueroa-Romero, C., Dunham, S. J. B., Faraci, G., Rothman, J. A., Whiteson, K. L., Seo, D. O., Holtzman, D. M., Grabrucker, S., Nolan, Y. M., Kaddurah-Daouk, R., & Jett, D. A. Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?, The Journal of Neuroscience, October 9, 2024, Read More
Carling, G. K., Fan, L., Foxe, N. R., Norman, K., Wong, M. Y., Zhu, D., Corona, C., Razzoli, A., Yu, F., Yarahmady, A., Ye, P., Chen, H., Huang, Y., Amin, S., Sereda, R., Lopez-Lee, C., Zacharioudakis, E., Chen, X., Xu, J., Cheng, F., … Gan, L. Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model, Neuron, September 24, 2024, Read More
Chen, Y., & Holtzman, D. M. New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies, Trends in Immunology, September 14, 2024, Read More
Sun, Z., Kwon, J. S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., Valdez, C., Houlden, H., Karch, C. M., Bateman, R. J., Sato, C., Mennerick, S. J., Diamond, M. I., Kim, J., Tanzi, R. E., Holtzman, D. M., Yoo, A. S. Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming, Science, August 8, 2024, Read More
Janelidze, S., Barthélemy, N. R., Salvadó, G., Schindler, S. E., Palmqvist, S., Mattsson-Carlgren, N., Braunstein, J. B., Ovod, V., Bollinger, J. G., He, Y., Li, Y., Raji, C. A., Morris, J. C., Holtzman, D. M., Ashton, N. J., Blennow, K., Stomrud, E., Bateman, R. J., & Hansson, O. Plasma Phosphorylated Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation in People Without Cognitive Impairment, JAMA Neurology, July 28, 2024, Read More
10. Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., … Gate, D., … , Iadecola, C., Johnson, L. A., Kanekiyo, T., … Lamb, B.T., … Marcora, E., … Morganti, J. M., … Ramachandran, K. V., … Tsai, L. H., … Ulrich, J. D., van der Kant, R., … Wellington, C. L., … Zhao, N., Bu, G., Goate, A. M., Holtzman, D. M. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference, Alzheimer's & Dementia, July 19, 2024, Read More
Zhu, Y., Self, W. K., & Holtzman, D. M. An emerging role for the gut microbiome in tauopathy, Neurotherapeutics, July 3, 2024, Read More
Xiong, C., Luo, J., Wolk, D. A., Shaw, L. M., Roberson, E. D., Murchison, C. F., Henson, R. L., Benzinger, T. L. S., Bui, Q., Agboola, F., Grant, E., Gremminger, E. N., Moulder, K. L., Geldmacher, D. S., Clay, O. J., Babulal, G., Cruchaga, C., Holtzman, D. M., Bateman, R. J., Morris, J. C., Schindler, S. E. Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals, Nature Communications, July 2, 2024, Read More
Hou, J., Chen, Y., Cai, Z., Heo, G. S., Yuede, C. M., … Holtzman, D. M. & Colonna, M. Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model, Science Translational Medicine, April 3, 2024, Read More
Salvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J., & Hansson, O. Disease staging of Alzheimer’s disease using a CSF-based biomarker model, Nature Aging, March 21, 2024, Read More
Bosch, M. E., Dodiya, H. B., Michalkiewicz, J., Lee, C., Shaik, S. M., Weigle, I. Q., Zhang, C., Osborn, J., Nambiar, A., Patel, P., Parhizkar, S., Zhang, X., Laury, M. L., Mondal, P., Gomm, A., Schipma, M. J., Mallah, D., Butovsky, O., Chang, E. B., Tanzi, R. E., Gilbert, J. A., Holtzman, D. M. & Sisodia, S. S. Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner, Molecular Neurodegeneration, February 17, 2024, Read More
Ma, Q., Zhao, Z., Sagare, A. P., Wu, Y., Wang, M., Owens, N. C., Verghese, P. B., Herz, J., Holtzman, D. M., & Zlokovic, B. V. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism, Molecular Neurodegeneration, October 19, 2018, Read More
Yamada, K., Cirrito, J. R., Stewart, F. R., Jiang, H., Finn, M. B., Holmes, B. B., Binder, L. I., Mandelkow, E. M., Diamond, M. I., Lee, V. M., & Holtzman, D. M. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice, Journal of Neuroscience, September 14, 2011, Read More
Andrew, R. J., Fernandez, C. G., Stanley, M., Jiang, H., Nguyen, P., Rice, R. C., Buggia-Prévot, V., De Rossi, P., Vetrivel, K. S., Lamb, R., Argemi, A., Allaert, E. S., Rathbun, E. M., Krause, S. V., Wagner, S. L., Parent, A. T., Holtzman, D. M., & Thinakaran, G. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzhiemer’s disease, Proceedings of the National Academy of Sciences of the United States of America, October 23, 2017, Read More
Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deussing, M., Focke, C., Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., Krasemann, S., Lichtenthaler, S. F., Müller, S. A., Colombo, A., Monasor, L. S., Tahirovic, S., Herms, J., Willem, M., Pettkus, N., Butovsky, O., Bartenstein, P., Edbauer, D., Rominger, A., Erturk, A., Grathwohl, S. A., Neher, J. J., Holtzman, D., Meyer-Leuhmann, M., & Haass, C. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE, Nature Neuroscience, February 1, 2019, Read More
Roh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J., & Holtzman, D. M. Disruption of the sleep-wake cycle and diurnal fluctuations of amyloid-beta in mice with Alzheimer’s disease pathology, Science Translational Medicine, September 5, 2012, Read More
Kang, J. E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. Amyloid beta dynamics are regulated by orexin and the sleep wake cycle, Science, November 13, 2009, Read More
Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P. S., Manis, M., Schroeder, C., Yin, Z., Madore, C., Butovsky, O., Artyomov, M., Ulrich, J. D., & Holtzman, D. M. Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia, Neuron, April 7, 2021, Read More
Krasemann, S., Madore, C., Cialic, R., Baufeld, C., ... Ulrich, J. D., … Lemere, C., Ikezu, T., ... Holtzman, D. M. … Haass, C., Butovsky, O. The TREM2-APOE Pathway drives the transcriptional phenotype of dysfunctional microglia in Neurodegenerative Diseases, Immunity, September 19, 2017, Read More
Steele, J. W., Kim, S. H., Cirrito, J. R., Verges, D. K., Restivo, J. L., Westaway, D., Fraser, P., Hyslop, P. S., Sano, M., Bezprozvanny, I., Ehrlich, M. E., Holtzman, D. M., & Gandy, S. Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo, Molecular Neurodegeneration, December 17, 2009, Read More
Chen, Y., Song, S., Parhizkar, S., Lord, J., Zhu, Y., Strickland, M. R., Wang, C., Park, J., Tabor, G. T., Jiang, H., Li, K., Davis, A. A., Yuede, C. M., Colonna, M., Ulrich, J. D., & Holtzman, D. M. APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread, Cell, December 11, 2023, Read More
Ulland, T. K., Song, W. M., Huang, S. C., Ulrich, J. D., Sergushichev, A., Beatty, W. L., Loboda, A. A., Zhou, Y., Cairns, N. J., Kambal, A., Loginicheva, E., Gilfillan, S., Cella, M., Virgin, H. W., Unanue, E. R., Wang, Y., Artyomov, M. N., Holtzman, D. M., & Colonna, M. TREM2 maintains Microglial metabolic fitness in Alzheimer’s Disease, Cell, August 10, 2017, Read More
Schindler, S. E., Cruchaga, C., Joseph, A., McCue, L., Farias, F. H. G., Wilkins, C. H., Deming, Y., Henson, R. L., Mikesell, R. J., Piccio, L., Llibre-Guerra, J. J., Moulder, K. L., Fagan, A. M., Ances, B. M., Benzinger, T. L. S., Xiong, C., Holtzman, D. M., & Morris, J. C. African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants, Neurology Genetics, March 4, 2021, Read More
Mahan, T. E., Wang, C., Bao, X., Choudhury, A., Ulrich, J. D., & Holtzman, D. M. Selective reduction of astrocyte apoE3 and apoE4 strongly reduces A beta accumulation and plaque-related pathology in a mouse model of amyloidosi, Molecular Neurodegeneration, February 2, 2022, Read More
Ulrich, J. D., & Holtzman, D. M. TREM2 Function in Alzheimer’s Disease and Neurodegeneration, ACS Chemical Neuroscience, February 8, 2016, Read More
Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D., & Holtzman, D. M. Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy, Nature, March 8, 2023, Read More
Ulrich, J. D., Burchett, J. M., Restivo, J. L., Schuler, D. R., Verghese, P. B., Mahan, T. E., Landreth, G. E., Castellano, J. M., Jiang, H., Cirrito, J. R., & Holtzman, D. M. In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis, Molecular Neurodegeneration, April 19, 2013, Read More
Ulrich, J. D., Ulland, T. K., Mahan, T. E., Nyström, S., Nilsson, K. P., Song, W. M., Zhou, Y., Reinartz, M., Choi, S., Jiang, H., Stewart, F. R., Anderson, E., Wang, Y., Colonna, M., & Holtzman, D. M. APoE facilitates the microglia response to amyloid plaque pathology, Journal of Experimental Medicine, February 26, 2018, Read More
Ulrich, J. D., Ulland, T. K., Colonna, M., & Holtzman, D. M. Elucidating the role of TREM2 in Alzheimer’s Disease, Neuron, April 19, 2017, Read More
Leyns, C. E. G., Ulrich, J. D., Finn, M. B., Stewart, F. R., Koscal, L. J., Remolina Serrano, J., Robinson, G. O., Anderson, E., Colonna, M., & Holtzman, D. M. TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy, Proceedings of the National Academy of Sciences of the United States of America, October 9, 2017, Read More
Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., Cella, M., Grutzendler, J., DeMattos, R. B., Cirrito, J. R., Holtzman, D. M., & Colonna, M. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques, Journal of Experimental Medicine, April 18, 2016, Read More
Liu, C. C., Zhao, N., Yamaguchi, Y., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid beta clearance and aggregation in Alzheimer’s disease, Science Translational Medicine, March 30, 2016, Read More
Liu, C. C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. Astrocytic LRP1 Mediates Brain A beta Clearance and Impacts Amyloid Deposition, Journal of Neuroscience, April 12, 2017, Read More
Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J., & Iadecola, C. Dietary salt promotes cognitive impairment through tau phosphorylation, Nature, October 23, 2019, Read More
Schwetye, K. E., Cirrito, J. R., Esparza, T. J., Mac Donald, C. L., Holtzman, D. M., & Brody, D. L. Traumatic brain injury reduces solubl extracellular amyloid-beta in mice: a methodologically novel combined microdialysis-controlled cortical impact study, Neurobiology of Disease, December 1, 2010, Read More
Brody, D. L., Magnoni, S., Schwetye, K. E., Spinner, M. L., Esparza, T. J., Stocchetti, N., Zipfel, G. J., & Holtzman, D. M. Amyloid-beta dynamics correlate with neurological status in the injured human brain, Science, August 29, 2008, Read More
Tran, H. T., LaFerla, F. M., Holtzman, D. M., & Brody, D. L. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid beta accumulation and independently accelerates the development of tau abnormalities, Journal of Neuroscience, June 29, 2011, Read More
Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., Holtzman, D. M., Cirrito, J. R., & Colonna, M. TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model, Cell, March 12, 2015, Read More
Ulrich, J. D., Finn, M. B., Wang, Y., Shen, A., Mahan, T. E., Jiang, H., Stewart, F. R., Piccio, L., Colonna, M., & Holtzman, D. M. Altered microglial response to A beta plaques in APPPS1-21 mice heterozygous for TREM2, Molecular Neurodegeneration, June 3, 2014, Read More
Chen, X., & Holtzman, D. M. Emerging roles of innate and adaptive immunity in Alzheimer’s disease, Immunity, December 13, 2022, Read More
Shi, Y., Manis, M., Long, J., Wang, K., Sullivan, P. M., Remolina Serrano, J., Hoyle, R., & Holtzman, D. M. Microglia derived APOE-dependent neurodegneration in a tauopathy mouse model, Journal of Experimental Medicine, November 4, 2019, Read More
Gallardo, G., & Holtzman, D. M. Antibody Therapeutics targeting Abeta and Tau, Cold Spring Harbor Perspectives in Medicine, October 1, 2017, Read More
Mann, C. N., Devi, S. S., Kersting, C. T., Bleem, A. V., Karch, C. M., Holtzman, D. M., & Gallardo, G. Astrocytic α2-Na+/K+ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model, Science Translational Medicine, February 16, 2022, Read More
Wilson, D. M., 3rd, Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. Hallmarks of neurodegenerative diseases, Cell, February 16, 2023, Read More
Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., Cella, M., Ulland, T. K., Zaitsev, K., Miyashita, A., Ikeuchi, T., Sainouchi, M., Kakita, A., Bennett, D. A., Schneider, J. A., Nichols, M. R., Beausoleil, S. A., Ulrich, J., Holtzman, D. M., Artyomov, M. N., & Colonna, M. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease, Nature Medicine, January 13, 2020, Read More
Stout, S. H., Babulal, G. M., Ma, C., Carr, D. B., Head, D. M., Grant, E. A., Williams, M. M., Holtzman, D. M., Fagan, A. M., Morris, J. C., & Roe, C. M. Driving cessation over a 24-hour period: dementia severity and cerebrospinal fluid markers, Alzheimer's & Dementia, May 1, 2018, Read More
Vos, S. J. B., Gordon, B. A., Su, Y., Visser, P. J., Holtzman, D. M., Morris, J. C., Fagan, A. M., & Benzinger, T. L. S. NIA-AA staging of preclinical Alzhiemer disease: discordance and concordance of CSF and imaging biomarkers, Neurobiology of Aging, April 4, 2016, Read More
Ances, B. M., Christensen, J. J., Teshome, M., Taylor, J., Xiong, C., Aldea, P., Fagan, A. M., Holtzman, D. M., Morris, J. C., Mintun, M. A., & Clifford, D. B. Cognitively unimpaired HIV-positive subjects do not have icreased C-11 PiB A case-control study, Neurology, July 13, 2010, Read More
Ovod, V., Ramsey, K. N., Mawuenyega, K. G., Bollinger, J. G., Hicks, T., Schneider, T., Sullivan, M., Paumier, K., Holtzman, D. M., Morris, J. C., Benzinger, T., Fagan, A. M., Patterson, B. W., & Bateman, R. J. Amyloid beta concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis, Alzheimer's & Dementia, July 19, 2017, Read More
Da Mesquita, S., Papadopoulos, Z., Dykstra, T., Brase, L., Farias, F. G., Wall, M., Jiang, H., Kodira, C. D., de Lima, K. A., Herz, J., Louveau, A., Goldman, D. H., Salvador, A. F., Onengut-Gumuscu, S., Farber, E., Dabhi, N., Kennedy, T., Milam, M. G., Baker, W., Smirnov, I., Rich, S. S., Dominantly Inherited Alzheimer Network, Benitez, B. A., Karch, C. M., Perrin, R. J., Farlow, M., Chhatwal, J. P., Holtzman, D. M., Cruchaga, C., Harari, O., & Kipnis, J. Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy, Nature, April 28, 2021, Read More
Wang, S., Sudan, R., Peng, V., Zhou, Y., Du, S., Yuede, C. M., Lei, T., Hou, J., Cai, Z., Cella, M., Nguyen, K., Poliani, P. L., Beatty, W. L., Chen, Y., Cao, S., Lin, K., Rodrigues, C., Ellebedy, A. H., Gilfillan, S., Brown, G. D., Holtzman, D. M., Brioschi, S., & Colonna, M. TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways, Cell, October 27, 2022, Read More
Horie, K., Salvadó, G., Barthélemy, N. R., Janelidze, S., Li, Y., He, Y., Saef, B., Chen, C. D., Jiang, H., Strandberg, O., Pichet Binette, A., Palmqvist, S., Sato, C., Sachdev, P., Koyama, A., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Mattsson-Carlgren, N., … Bateman, R. J. CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease, Nature Medicine, July 13, 2023, Read More
Esparza, T. J., Zhao, H., Cirrito, J. R., Cairns, N. J., Bateman, R. J., Holtzman, D. M., & Brody, D. L. Amyloid beta oligomerization in Alzheimer’s dementia versus high pathology controls, Annals of Neurology, January 1, 2013, Read More
Lawler, P. E., Bollinger, J. G., Schindler, S. E., Hodge, C. R., Iglesias, N. J., Krishnan, V., Coulton, J. B., Li, Y., Holtzman, D. M., & Bateman, R. J. Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype, Analytical Biochemistry, April 16, 2023, Read More
Leyns, C. E. G., Gratuze, M., Narasimhan, S., Jain, N., Koscal, L. J., Jiang, H., Manis, M., Colonna, M., Lee, V. M. Y., Ulrich, J. D., & Holtzman, D. M. TREM2 Function Impedes Tau Seeding in Neuritic Plaques, Nature Neuroscience, June 1, 2019, Read More
Self, W. K., & Holtzman, D. M. Emerging diagnostics and therapeutics for Alzheimer disease, Nature Medicine, September 4, 2023, Read More
Xiong, M., Wang, C., Gratuze, M., Saadi, F., Bao, X., Bosch, M. E., Lee, C., Jiang, H., Serrano, J. R., Gonzales, E. R., Kipnis, M., & Holtzman, D. M. Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy, Molecular Neurodegenration, March 16, 2023, Read More
Liao, F., Jiang, H., Srivatsan, S., Xiao, Q., Lefton, K. B., Yamada, K., Mahan, T. E., Lee, J. M., Shaw, A. S., & Holtzman, D. M. Effects of CD2-associated protein deficiency on amyloid-beta in neuroblastoma cells and in an APP transgenic mouse model., Molecular Neurodegeneration, March 19, 2015, Read More
Verges, D. K., Restivo, J. L., Goebel, W. D., Holtzman, D. M., & Cirrito, J. R. Opposing synaptic regulation of amyloid-beta metabolism by NMDA Receptors in vivo, Journal of Neuroscience, August 3, 2011, Read More
Lim, M. M., Xu, J., Holtzman, D. M., & Mach, R. H. Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum, NeuroReport, July 13, 2011, Read More
Yan, P., Bero, A. W., Cirrito, J. R., Xiao, Q., Hu, X., Wang, Y., Gonzales, E., Holtzman, D. M., & Lee, J. M. Characterizing the Appearance and Growth of Amyloid plaques in APP/PS1 Mice, Journal of Neuroscience, August 26, 2009, Read More
Roh, J. H., Jiang, H., Finn, M. B., Stewart, F. R., Mahan, T. E., Cirrito, J. R., Heda, A., Snider, B. J., Li, M., Yanagisawa, M., de Lecea, L., & Holtzman, D. M. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease, Journal of Experimental Medicine, November 24, 2014, Read More
Kim, J., Eltorai, A. E., Jiang, H., Liao, F., Verghese, P. B., Kim, J., Stewart, F. R., Basak, J. M., & Holtzman, D. M. Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of A beta amyloidosis, Journal of Experimental Medicine, November 19, 2012, Read More
Cao, C., Cirrito, J. R., Lin, X., Wang, L., Verges, D. K., Dickson, A., Mamcarz, M., Zhang, C., Mori, T., Arendash, G. W., Holtzman, D. M., & Potter, H. Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer’s disease transgenic mice, Journal of Alzheimers Disease, July 1, 2009, Read More
Roh, J. H., & Holtzman, D. M. Is there a link between the sleep-wake cycle and Alzheimer’s pathology, Future Neurology, May 1, 2015, Read More
Garai, K., Verghese, P. B., Baban, B., Holtzman, D. M., & Frieden, C. The binding of apolipoprotein E to oligomers and fibrils of amyloid-beta alters the kinetics of amyloid aggregation, Biochemistry, September 25, 2014, Read More
Long, J. M., & Holtzman, D. M. Alzhiemer’s Disease: an update on pathobiology and treatment strategies, Cell, September 26, 2019, Read More
Zeng, C., Pan, F., Jones, L. A., Lim, M. M., Griffin, E. A., Sheline, Y. I., Mintun, M. A., Holtzman, D. M., & Mach, R. H. Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system, Brain Research, March 1, 2010, Read More
Shi, Y., & Holtzman, D. M. Interplay between Innate immunity and Alzheimer’s disease: APOE ad TREM2 in the spotlight, Nature Reviews Immunology, August 23, 2018, Read More
Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J. M., & Holtzman, D. M. Neuronal activity regulates the regional vulnerability to amyloid-beta deposition, Nature Neuroscience, June 1, 2011, Read More
Chen, Y., Strickland, M. R., Soranno, A., & Holtzman, D. M. Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis, Neuron, November 10, 2020, Read More
Tabor, G. T., & Holtzman, D. M. Current status of amyloid-targeting immunotherapies for Alzheimer’s disease, Science Translational Medicine, November 8, 2023, Read More
Yan, P., Zhu, A., Liao, F., Xiao, Q., Kraft, A., Gonzales, E., Perez, R., Greenberg, S. M., Holtzman, D., & Lee, J. M. Minocycline reduces spontaneous hemorrhage in mouse models of cerebral amyloid angiopathy, Stroke, June 1, 2015, Read More
Parhizkar, S., & Holtzman, D. M. APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease, Seminars in Immunology, February 26, 2022, Read More
Wander, C. M., Tsujimoto, T. H. M., Ervin, J. F., Wang, C., Maranto, S. M., Bhat, V., Dallmeier, J. D., Wang, S. J., Lin, F. C., Scott, W. K., Holtzman, D. M., & Cohen, T. J. Corpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease, Acta Neuropathologica Communications, August 8, 2022, Read More
Holth, J. K., Mahan, T. E., Robinson, G. O., Rocha, A., & Holtzman, D. M. Altered sleep and EEG power in the P301S tau transgenic mouse model, Annals of Clinical and Translational Neurology, March 1, 2017, Read More
Liao, F., Hori, Y., Hudry, E., Bauer, A. Q., Jiang, H., Mahan, T. E., Lefton, K. B., Zhang, T. J., Dearborn, J. T., Kim, J., Culver, J. P., Betensky, R., Wozniak, D. F., Hyman, B. T., & Holtzman, D. M. Anti-ApoE Antibody given after plaque onset decreases A beta accumulation and improves brain function in a mouse model of a beta amyloidosis, Journal of Neuroscience, May 21, 2014, Read More
Cadiz, M. P., Gibson, K. A., Todd, K. T., Nascari, D. G., Massa, N., Lilley, M. T., Olney, K. C., Al-Amin, M. M., Jiang, H., Holtzman, D. M., & Fryer, J. D. Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations, Journal of Experimental Medicine, January 16, 2024, Read More
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