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Filip Swirski, Ph.D.

Arthur and Janet C. Ross Professor of Medicine (Cardiology), Professor of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai. Director of the Cardiovascular Research Institute

Fil Swirski, Ph.D., is the Arthur and Janet C. Ross Professor of Medicine (Cardiology) and Professor of Diagnostic, Molecular and Interventional Radiology at the Icahn School of Medicine at Mount Sinai, as well as Director of the Cardiovascular Research Institute. He has secondary appointments at the Precision Immunology Institute and the BioMedical Engineering and Imaging Institute. Dr. Swirski has been recognized nationally and internationally as a leader in the field of innate immunity and inflammation in disease. He focuses on fundamental and translational cardiovascular science within the context of the hematologic, immune, metabolic, and nervous systems, with specific emphasis on cell development, communication, and function. Recently, his work has expanded to include lifestyle factors such as sleep, diet, and stress as critical modulators of cardiovascular health and hematopoiesis.

Dr. Swirski obtained his Ph.D. at McMaster University in Hamilton, Canada, and postdoctoral studies at Brigham and Women’s Hospital in Boston. Dr. Swirski was Professor at Harvard Medical School and Principal Investigator at Massachusetts General Hospital before joining Mount Sinai in 2021. Dr. Swirski is a Highly Cited Researcher and is the recipient of numerous awards including the Jeffrey M. Hoeg Award from the American Heart Association, the William Harvey Lecture from the European Society of Cardiology, the Martin Prize for Fundamental Research, the Howard M. Goodman Fellowship, and was the Patricia and Scott Eston Research Scholar from Massachusetts General Hospital. Dr. Swirski holds an Outstanding Investigator Award from the NHLBI, an Established Investigator Award from the AHA, an investigator grant from Cure Alzheimer’s Fund, and is the North American Coordinator of a Leducq Foundation Transatlantic Network of Excellence Consortium.

Filip Swirski: @SwirskiLab

Mount Sinai CVRI: @SinaiHeartBlood

 

Related Research:

Role of Psychosocial Stress in Alzheimer’s Disease Filip Swirski 2024-10-31 Investigating Bone Marrow Hematopoiesis as the Link Between Sleep Fragmentation and Vascular Inflammation in AD Cameron McAlpine Filip Swirski 2022-02-15 Interleukin-3 in Alzheimer’s Disease Filip Swirski 2018-12-27 Systemic Inflammatory Networks in Alzheimer’s Disease Filip Swirski Matthias Nahrendorf 2015-10-29

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Role of Psychosocial Stress in Alzheimer’s Disease 2024

$201,250
Investigating Bone Marrow Hematopoiesis as the Link Between Sleep Fragmentation and Vascular Inflammation in AD 2021, 2023

$345,000
Interleukin-3 in Alzheimer’s Disease 2018-2019

$344,846
Systemic Inflammatory Networks in Alzheimer’s Disease 2015, 2016

$400,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kiss, M. G., Cohen, O., McAlpine, C. S., & Swirski, F. K. Influence of sleep on physiological systems in atherosclerosis, Nature Cardiovascular Research, November 8, 2024, Read More

Huynh, P., Hoffmann, J. D., Gerhardt, T., Kiss, M. G., Zuraikat, F. M., Cohen, O., Wolfram, C., Yates, A. G., Leunig, A., Heiser, M., Gaebel, L., Gianeselli, M., Goswami, S., Khamhoung, A., Downey, J., Yoon, S., Chen, Z., Roudko, V., Dawson, T., Ferreira da Silva, J., … McAlpine, C. S. Myocardial infarction augments sleep to limit cardiac inflammation and damage, Nature, October 30, 2024, Read More

Flayer, C. H., Kernin, I. J., Matatia, P. R., Zeng, X., Yarmolinsky, D. A., Han, C., Naik, P. R., Buttaci, D. R., Aderhold, P. A., Camire, R. B., Zhu, X., Tirard, A. J., McGuire, J. T., Smith, N. P., McKimmie, C. S., McAlpine, C. S., Swirski, F. K., Woolf, C. J., Villani, A. C., & Sokol, C. L. A γδ T cell–IL-3 axis controls allergic responses through sensory neurons, Nature, September 4, 2024, Read More

Chan, K. L., Poller, W. C., Swirski, F. K., & Russo, S. J. Central regulation of stress-evoked peripheral immune responses, Nature Reviews Neuroscience, August 25, 2023, Read More

Kiss, M. G., Mindur, J. E., Yates, A. G., … Nahrendorf, M., … Swirski, F.K. & McAlpine, C. S. Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis, Immunity, May 8, 2023, Read More

Hoyer, F. F., Naxerova, K., Schloss, M. J., Hulsmans, M., Nair, A. V., Dutta, P., Calcagno, D. M., Herisson, F., Anzai, A., Sun, Y., Wojtkiewicz, G., Rohde, D., Frodermann, V., Vandoorne, K., Courties, G., Iwamoto, Y., Garris, C. S., Williams, D. L., Breton, S., Brown, D., Whalen, M., Libby, P., Pittet, M. J., King, K. R., Weissleder, R., Swirski, F. K., & Nahrendorf, M., Tissue-specific macrophage responses to remote injury impact the outcome of subsequent local immune challenges, Immunity, November 19, 2019, Read More

Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., Kim, D. E., Weissleder, R., Swirski, F. K., Moskowitz, M. A., & Nahrendorf, M. Direct Vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration, Nature Neuroscience, August 27, 2018, Read More

McAlpine, C. S., Kiss, M. G., Zuraikat, F. M., Cheek, D., Schiroli, G., Amatullah, H., Huynh, P., Bhatti, M. Z., Wong, L. P., Yates, A. G., Poller, W. C., Mindur, J. E., Chan, C. T., Janssen, H., Downey, J., Singh, S., Sadreyev, R. I., Nahrendorf, M., Jeffrey, K. L., Scadden, D. T., Naxerova, K., St-Onge, M., & Swirski, F.K. Sleep exerts lasting effects on hematopoietic stem cell function and diversity, Journal of Experimental Medicine, September 21, 2022, Read More

Janssen, H., Kahles, F., Liu, D., Downey, J., Koekkoek, L. L., Roudko, V., D'Souza, D., McAlpine, C. S., Halle, L., Poller, W. C., Chan, C. T., He, S., Mindur, J. E., Kiss, M. G., Singh, S., Anzai, A., Iwamoto, Y., Kohler, R. H., Chetal, K., Sadreyev, R. I., Weissleder, R., Kim-Schulze, S., Merad, M., Nahrendorf, M., & Swirski, F. K. Monocytes re-enter the bone marrow during fasting and alter the host response to infection, Immunity, February 23, 2023, Read More

McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., Mindur, J. E., Chan, C. T., He, S., Janssen, H., Wong, L. P., Downey, J., Singh, S., Anzai, A., Kahles, F., Jorfi, M., Feruglio, P.F., Sadreyev, R. I., Weissleder, R., Kleinstiver, B. P., Nahrendorf, M., Tanzi, R. E., & Swirski, F. K. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature, July 14, 2021, Read More

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