Cure Alzheimer's Fund Cure Alzheimer's Fund

George S. Bloom, Ph.D.

Professor of Biology, Cell Biology, and Neuroscience, University of Virginia

Dr. Bloom obtained his Bachelor of Arts degree from the University of Pennsylvania in 1973 and his Ph.D. from the University of Pennsylvania in 1979. He then completed two postdoctoral fellowships: from 1979–1980 at the University of North Carolina’s Cancer Research Center, and from 1980–1984 at the Worcester Foundation for Experimental Biology, where his longstanding interest in neuronal cell biology was initiated in the laboratory of Dr. Richard Vallee. After finishing his postdoctoral training in 1984, Dr. Bloom joined the faculty of the Department of Cell Biology at the University of Texas Southwestern Medical Center, where he remained until his move to the University of Virginia in 2000.

Related Research:

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Toxic Effects of Extracellular Tau Oligomers on Neurons 2022

$198,932
Adult Human iNeurons: A Next-Generation Drug Screening Platform for Alzheimer’s Disease 2020, 2021

$444,498
Targeting Cell Cycle Re-entry Using 3-D Neuron Cultures 2017 and 2018

$420,681
Cell Cycle Re-entry in 3-D Human Neuron Cultures 2015, 2016

$200,000
Structural and Functional Analysis of Novel Abeta and Tau Oligomers Using Conformation-Specific Monoclonal Antibodies 2011

$100,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

George S. Bloom Amyloid-β and Tau: The Trigger and Bullet in Alzheimer Disease Pathogenesis, JAMA Neurology, April 2014, Read More

Erin J. Kodis, Sophie Choi, Eric Swanson, Gonzalo Ferreira, George S. Bloom N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer’s disease, Alzheimer's and Dementia, June 2018, Read More

George S.Bloom, John S.Lazo, Andrés Norambuena Reduced brain insulin signaling: A seminal process in Alzheimer’s disease pathogenesis, Neuropharmacology, 29 Sep 2017, Read More

Andrés Norambuena, Horst Wallrabe, Lloyd McMahon, Antonia Silva, Eric Swanson, Shahzad S. Khan, Daniel Baerthlein, Erin Kodis, Salvatore Oddo, James W. Mandell, George S. Bloom mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia, 13(2), Feb 2017, 152-167, Read More

Shahzad S. Khan and George S. Bloom Tau: The Center of a Signaling Nexus in Alzheimer’s Disease, Frontiers in Neuroscience, February 2016, Read More

Nussbaum, JM; Schilling, S; Cynis, H; Silva, A; Swanson, E; Wangsanut, T; Tayler, K; Wiltgen, B; Hatami, A; Ronicke, R; Reymann, K; Hutter-Paier, B; Alexandru, A; Jagla, W; Graubner, S; Glabe, CG; Demuth, HU; Bloom, GS Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β, Nature, 485, May 2, 2012, 651-655, Read More

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