These projects were made possible from Cure Alzheimer's Fund support.
|Toxic Effects of Extracellular Tau Oligomers on Neurons||
|Adult Human iNeurons: A Next-Generation Drug Screening Platform for Alzheimer’s Disease||
|Targeting Cell Cycle Re-entry Using 3-D Neuron Cultures||
2017 and 2018
|Cell Cycle Re-entry in 3-D Human Neuron Cultures||
|Structural and Functional Analysis of Novel Abeta and Tau Oligomers Using Conformation-Specific Monoclonal Antibodies||
These published papers resulted from Cure Alzheimer’s Fund support.
Erin J. Kodis, Sophie Choi, Eric Swanson, Gonzalo Ferreira, George S. Bloom N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer’s disease, Alzheimer's and Dementia, June 2018, Read More
George S.Bloom, John S.Lazo, Andrés Norambuena Reduced brain insulin signaling: A seminal process in Alzheimer’s disease pathogenesis, Neuropharmacology, 29 Sep 2017, Read More
Andrés Norambuena, Horst Wallrabe, Lloyd McMahon, Antonia Silva, Eric Swanson, Shahzad S. Khan, Daniel Baerthlein, Erin Kodis, Salvatore Oddo, James W. Mandell, George S. Bloom mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia, 13(2), Feb 2017, 152-167, Read More
Shahzad S. Khan and George S. Bloom Tau: The Center of a Signaling Nexus in Alzheimer’s Disease, Frontiers in Neuroscience, February 2016, Read More
Nussbaum, JM; Schilling, S; Cynis, H; Silva, A; Swanson, E; Wangsanut, T; Tayler, K; Wiltgen, B; Hatami, A; Ronicke, R; Reymann, K; Hutter-Paier, B; Alexandru, A; Jagla, W; Graubner, S; Glabe, CG; Demuth, HU; Bloom, GS Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β, Nature, 485, May 2, 2012, 651-655, Read More