These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Toxic Effects of Extracellular Tau Oligomers on Neurons |
2022, 2023 $390,952 |
|
Adult Human iNeurons: A Next-Generation Drug Screening Platform for Alzheimer’s Disease |
2020, 2021 $444,498 |
|
Targeting Cell Cycle Re-entry Using 3-D Neuron Cultures |
2017 and 2018 $420,681 |
|
Cell Cycle Re-entry in 3-D Human Neuron Cultures |
2015, 2016 $200,000 |
|
Structural and Functional Analysis of Novel Abeta and Tau Oligomers Using Conformation-Specific Monoclonal Antibodies |
2011 $100,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
Norambuena, A., Sagar, V. K., Wang, Z., Raut, P., Feng, Z., Wallrabe, H., Pardo, E., Kim, T., Alam, S. R., Hu, S., Periasamy, A., & Bloom, G. S. Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock-in mouse model of Alzheimer’s disease, Alzheimer's & Dementia, August 22, 2024, Read More
Norambuena, A., Wallrabe, H., Cao, R., Wang, D. B., Silva, A., Svindrych, Z., Periasamy, A., Hu, S., Tanzi, R. E., Kim, D. Y., & Bloom, G. S. A novel lysosome-to-micochondria signaling pathway disrupted by amyloid-beta oligomes, The EMBO Journal, October 22, 2018, Read More
Porterfield, V., Khan, S. S., Foff, E. P., Koseoglu, M. M., Blanco, I. K., Jayaraman, S., Lien, E., McConnell, M. J., Bloom, G. S., Lazo, J. S., & Sharlow, E. R. A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype, Neurobiology of Aging, February 19, 2020, Read More
Bloom, G. S., Lazo, J. S., & Norambuena, A. Reduced brain insulin signaling: A seminal process in Alzheimer’s disease pathogenesis, Neuropharmacology, September 27, 2017, Read More
Nussbaum, J. M., Schilling, S., Cynis, H., Silva, A., Swanson, E., Wangsanut, T., Tayler, K., Wiltgen, B., Hatami, A., Rönicke, R., Reymann, K., Hutter-Paier, B., Alexandru, A., Jagla, W., Graubner, S., Glabe, C. G., Demuth, H. U., & Bloom, G. S. Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta, Nature, May 2, 2012, Read More
Wu, L., Wang, Z., Lad, S., Gilyazova, N., Dougharty, D. T., Marcus, M., Henderson, F., Ray, W. K., Siedlak, S., Li, J., Helm, R. F., Zhu, X., Bloom, G. S., Wang, S. J., Zou, W. Q., & Xu, B. Selective Detection of Misfolded Tau From Postmortem Alzheimer’s Disease Brains, Frontiers in Aging Neuroscience, July 20, 2022, Read More
Nussbaum, J. M., Seward, M. E., & Bloom, G. S. Alzheimer disease A tale of two prions, Prion, September 10, 2012, Read More
Norambuena, A., Sun, X., Wallrabe, H., Cao, R., Sun, N., Pardo, E., Shivange, N., Wang, D. B., Post, L. A., Ferris, H. A., Hu, S., Periasamy, A., & Bloom, G. S. SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers, Neurobiology of Disease, April 20, 2022, Read More
Khan, S. S., & Bloom, G. S. Tau: the center of a signaling nexus in Alzheimer’s disease, Frontiers in Neuroscience, February 9, 2016, Read More
Bloom, G. S., & Norambuena, A. Alzheimer’s disease as a metabolic disorder, Lipids, August 1, 2018, Read More
Swanson, E., Breckenridge, L., McMahon, L., Som, S., McConnell, I., & Bloom, G. S. Extracellular tau oligomers induce invasion of endogenous tau into the somatodendritic compartment and axonal transport dysfunction, Journal of Alzhiemer's Disease, January 1, 2017, Read More
Rudenko, L. K., Wallrabe, H., Periasamy, A., Siller, K. H., Svindrych, Z., Seward, M. E., Best, M. N., & Bloom, G. S. Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-beta Oligomers, Journal of Alzheimer's Disease, October 15, 2019, Read More
Best, M. N., Lim, Y., Ferenc, N. N., Kim, N., Min, L., Wang, D. B., Sharifi, K., Wasserman, A. E., McTavish, S. A., Siller, K. H., Jones, M. K., Jenkins, P. M., Mandell, J. W., & Bloom, G. S. Extracellular Tau Oligomers Damage the Axon Initial Segment, Journal of Alzheimer's Disease, May 9, 2023, Read More
Kuwar, R., Rolfe, A., Di, L., Blevins, H., Xu, Y., Sun, X., Bloom, G. S., Zhang, S., & Sun, D. A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer’s Disease Transgenic Mice, Journal of Alzheimer's Disease, January 1, 2021, Read More
Bloom, G. S. Amyloid-beta and Tau: the trigger and bullet in Alzheimer’s disease pathogenesis, JAMA Neurology, April 1, 2014, Read More
Bloom, G. S., & Baas, P. W. A half-century of tau, Cytoskeleton, August 28, 2023, Read More
Bloom, G. S., & Norambuena, A. Dysregulation of mTOR by tau in Alzheimer’s disease, Cytoskeleton, August 28, 2023, Read More
Kodis, E. J., Choi, S., Swanson, E., Ferreira, G., & Bloom, G. S. N-methyl-D-aspartate receptor-mediated calciuym influx connects amyloid-beta oligomers to ectopic neuronal cell cycle re-entry in Alzheimer’s Disease, Alzheimer's & Dementia, October 1, 2018, Read More
Rajbanshi, B., Guruacharya, A., Mandell, J. W., & Bloom, G. S. mTOR and neuronal cell cycle re-entry: how impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia, February 1, 2017, Read More
Rajbanshi, B., Guruacharya, A., M|ell, J. W., & Bloom, G. S. Localization, induction, and cellular effects of tau phosphorylated at threonine 217, Alzheimer's & Dementia, January 12, 2023, Read More
Khan, S. S., LaCroix, M., Boyle, G., Sherman, M. A., Brown, J. L., Amar, F., Aldaco, J., Lee, M. K., Bloom, G. S., & Lesné, S. E. Bidirectional modulation of Alzhiemer’s phenotype by alpha-synuclein in mice and primary neurons, Acta Neuropathologica, October 1, 2018, Read More
Sun, X., Eastman, G., Shi, Y., Saibaba, S., Oliveira, A. K., Lukens, J. R., Norambuena, A., Thompson, J. A., Purdy, M. D., Dryden, K., Pardo, E., Mandell, J. W., & Bloom, G. S. Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers, Alzheimer's & Dementia, December 9, 2023, Read More
Sharlow, E. R., Leimgruber, S., Lira, A., McConnell, M. J., Norambuena, A., Bloom, G. S., Epperly, M. W., Greenberger, J. S., & Lazo, J. S. A Small molecule screen exposes mTOR signaling pathway involvement in radiation-induced apoptosis, ACS Chemical Biology, May 14, 2016, Read More
Eastman, G., Sharlow, E. R., Lazo, J. S., Bloom, G. S., & Sotelo-Silveira, J. R. Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer’s Disease Model Mice, Journal of Alzheimer's Disease, March 8, 2022, Read More
Sharlow, E. R., Llaneza, D. C., Grever, W. E., Mingledorff, G. A., Mendelson, A. J., Bloom, G. S., & Lazo, J. S. High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons, SLAS Discovery, October 20, 2022, Read More
Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer, Journal of Alzheimer's Disease, January 8, 2019, Read More
Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. Aberrant neuronal cell-cycle re-entry: the pathological confluence fo Alzheimer’s disease and brain insulin resistance, and its relation to cancer., Journal of Alzheimer's Disease, January 8, 2019, Read More
Sharlow, E. R., Llaneza, D. C., Tewari, B. P., Mingledorff, G. A., Mendelson, A. J., Sontheimer, H., Bloom, G. S., & Lazo, J. S. Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations, FEBS Journal, July 10, 2023, Read More
Sharlow, E. R., Koseoglu, M. M., Bloom, G. S., & Lazo, J. S. The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons, Assay and Drug Development Technologies, February 14, 2020, Read More