Cure Alzheimer's Fund Cure Alzheimer's Fund

John S. Lazo, Ph.D.

Harrison Distinguished Professor Emeritus, Departments of Pharmacology and Chemistry, University of Virginia. 

Allegheny Foundation Professor Emeritus, Department of Pharmacology and Chemical Biology, University of Pittsburgh

Acclaimed for his work in molecular pharmacology and cancer drug research and drug discovery, Dr. Lazo is the recipient of many awards and honors.

Dr. Lazo graduated from The Johns Hopkins University with a bachelor of arts degree in chemistry and a Ph.D. in pharmacology from the University of Michigan. He received postdoctoral training at Yale University and was a member of the pharmacology faculty at Yale University (12 years), the University of Pittsburgh (24 years) and the University of Virginia (11 years). Dr. Lazo served as a corporate associate of Johnson & Johnson, has co-founded four biotechnology companies, has authored 11 books, published more than 300 scientific articles and reviews and has been the principal investigator on numerous research projects.

Related Research:

Adult Human iNeurons: A Next-Generation Drug Screening Platform for Alzheimer’s Disease George S. Bloom Elizabeth R. Sharlow John S. Lazo 2020-12-21 Targeting Cell Cycle Re-entry Using 3-D Neuron Cultures Elizabeth R. Sharlow George S. Bloom John S. Lazo 2018-08-27 Cell Cycle Re-entry in 3-D Human Neuron Cultures John S. Lazo George S. Bloom 2015-09-28

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Adult Human iNeurons: A Next-Generation Drug Screening Platform for Alzheimer’s Disease 2020, 2021

$444,498
Targeting Cell Cycle Re-entry Using 3-D Neuron Cultures 2017 and 2018

$420,681
Cell Cycle Re-entry in 3-D Human Neuron Cultures 2015, 2016

$200,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Lazo, J. S., Isbell, K. N., Vasa, S. A., Llaneza, D. C., Rastelli, E. J., Wipf, P., & Sharlow, E. R. Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase, Journal of Pharmacology and Experimental Therapeutics, February 23, 2023, Read More

Czub, M. P., Boulton, A. M., Rastelli, E. J., Tasker, N. R., Maskrey, T. S., Blanco, I. K., McQueeney, K. E., Bushweller, J. H., Minor, W., Wipf, P., Sharlow, E. R., & Lazo, J. S. Structure of the complex of an iminopyridinedione PTP4A3 phosphatase inhibitor with human serum albumin, Molecular Pharmacology, September 25, 2020, Read More

Lazo, J. S., McQueeney, K. E., & Sharlow, E. R. New Approaches to Difficult Drug Discovery, SLAS Discovery, July 26, 2017, Read More

Lazo, J. S., McQueeney, K. E., Salamoun. J. M., Barabutis, N., Catravas, J.D., Wipf, P. A potent selective allosteric PTP4A3 phosphatase inhibitor enhances microvascular barrier function and inhibits human tumor cell growth, The FASEB Journal, April 1, 2018, Read More

Lazo, J. S., McQueeney, K. E., Burnett, J. C., Wipf, P., & Sharlow, E. R. Small molecule targeting of PTPs in Cancer, International Journal of Biochemistry & Cell Biology, September 21, 2017, Read More

Bloom, G. S., Lazo, J. S., & Norambuena, A. Reduced brain insulin signaling: A seminal process in Alzheimer’s disease pathogenesis, Neuropharmacology, September 27, 2017, Read More

Porterfield, V., Khan, S. S., Foff, E. P., Koseoglu, M. M., Blanco, I. K., Jayaraman, S., Lien, E., McConnell, M. J., Bloom, G. S., Lazo, J. S., & Sharlow, E. R. A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype, Neurobiology of Aging, February 19, 2020, Read More

Sharlow, E. R., Leimgruber, S., Lira, A., McConnell, M. J., Norambuena, A., Bloom, G. S., Epperly, M. W., Greenberger, J. S., & Lazo, J. S. A Small molecule screen exposes mTOR signaling pathway involvement in radiation-induced apoptosis, ACS Chemical Biology, May 14, 2016, Read More

Sharlow, E. R., Koseoglu, M. M., Bloom, G. S., & Lazo, J. S. The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons, Assay and Drug Development Technologies, February 14, 2020, Read More

Sharlow, E. R., Llaneza, D. C., Tewari, B. P., Mingledorff, G. A., Mendelson, A. J., Sontheimer, H., Bloom, G. S., & Lazo, J. S. Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations, FEBS Journal, July 10, 2023, Read More

Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. Aberrant neuronal cell-cycle re-entry: the pathological confluence fo Alzheimer’s disease and brain insulin resistance, and its relation to cancer., Journal of Alzheimer's Disease, January 8, 2019, Read More

Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer, Journal of Alzheimer's Disease, January 8, 2019, Read More

Sharlow, E. R., Llaneza, D. C., Grever, W. E., Mingledorff, G. A., Mendelson, A. J., Bloom, G. S., & Lazo, J. S. High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons, SLAS Discovery, October 20, 2022, Read More

Eastman, G., Sharlow, E. R., Lazo, J. S., Bloom, G. S., & Sotelo-Silveira, J. R. Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer’s Disease Model Mice, Journal of Alzheimer's Disease, March 8, 2022, Read More

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