Kevin Rynearson, B.S., M.S., Ph.D.

Assistant Project Scientist, Neurosciences, University of California, San Diego

Dr. Rynearson is a Project Scientist in the Department of Neurosciences at the University of California, San Diego (UCSD) School of Medicine. He received his B.S. in Chemistry from San Diego State University. Subsequently, Dr. Rynearson earned his M.S. and Ph.D. in Chemistry at UCSD under the supervision of Dr. Thomas Hermann, conducting research aimed at developing novel small molecules biased for interaction with therapeutically relevant RNA targets. From there, Dr. Rynearson received Postdoctoral training in translational medicine, pharmacology, and drug discovery in the laboratory of Dr. Steven Wagner. Currently, his research focuses on the development of gamma-secretase modulators as a potential treatment for Alzheimer’s disease (AD) and has reached Phase I clinical trials. His research is also interested in identifying alternative and complementary therapeutic approaches for AD. Dr. Rynearson is continuing the tremendous work of his mentor, Dr. Steven L. Wagner.



Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Chen, X. Q., Becker, A., Albay, R., Nguyen, P. D., Karachentsev, D., Roberts, A. J., Rynearson, K. D., Tanzi, R. E., & Mobley, W. C. γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome, Annals of Neurology, May 15, 2024, Read More

Chen, X. Q., Sawa, M., Becker, A., Karachentsev, D., Zuo, X., Rynearson, K. D., Tanzi, R. E., & Mobley, W. C. Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator, Annals of Neurology, April 11, 2023, Read More

Rynearson, K. D., Buckle, R. N., Herr, R. J., Mayhew, N. J., Chen, X., Paquette, W. D., Sakwa, S. A., Yang, J., Barnes, K. D., Nguyen, P., Mobley, W. C., Johnson, G., Lin, J. H., Tanzi, R. E., & Wagner, S. L. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators, Bioorganic and Medicinal Chemistry, September 1, 2020, Read More