Cure Alzheimer's Fund Cure Alzheimer's Fund

Katherine Schwetye, M.D., Ph.D.

Associate Professor, Pathology & Immunology, Washington University School of Medicine in St. Louis

Dr. Kate Schwetye earned a combined M.D.-Ph.D. from Washington University School of Medicine in St. Louis (WUSTL), where she worked in the labs of Drs. David Holtzman and David Brody studying the dynamics of amyloid-beta peptide in vivo in the brain interstitial fluid in a mouse model of traumatic injury to better understand the link between head trauma and dementia. She completed a combined Anatomic Pathology residency, Surgical Pathology fellowship, and Neuropathology fellowship at WUSTL. After several years in academic pathology practice, she returns to WU to continue the work initiated by Dr. Randall Bateman and his laboratory to better understand the in vivo dynamics of amyloid-beta and other peptides, proteins, and biomolecules within amyloid deposits in the brain parenchyma and vessels using stable-isotope labeling techniques.

Related Research:

Stable Isotope Labeling and Quantitative Mass Spectrometry Imaging of Alzheimer’s Disease Pathology in Human Brain Katherine Schwetye 2018-04-27

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Stable Isotope Labeling and Quantitative Mass Spectrometry Imaging of Alzheimer’s Disease Pathology in Human Brain 2017 and 2019

$300,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Schwetye, K. E., Cirrito, J. R., Esparza, T. J., Mac Donald, C. L., Holtzman, D. M., & Brody, D. L. Traumatic brain injury reduces solubl extracellular amyloid-beta in mice: a methodologically novel combined microdialysis-controlled cortical impact study, Neurobiology of Disease, December 1, 2010, Read More

Brody, D. L., Magnoni, S., Schwetye, K. E., Spinner, M. L., Esparza, T. J., Stocchetti, N., Zipfel, G. J., & Holtzman, D. M. Amyloid-beta dynamics correlate with neurological status in the injured human brain, Science, August 29, 2008, Read More

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