Lance Johnson, Ph.D.

Assistant Professor, Department of Physiology, University of Kentucky

Dr. Johnson is an Assistant Professor in the Department of Physiology and Sanders Brown Center of Aging at the University of Kentucky. Research in Dr. Johnson’s lab is dedicated to understanding the role of the  Alzheimer’s disease risk factor Apolipoprotein E (APOE) in cerebral metabolism. With a special focus on glia and their contributions to neurodegeneration, his lab employs a variety of transcriptomic and metabolomic approaches (from cells to mice to humans) in order to identify early-life changes in metabolism associated with APOE. The Johnson lab’s overarching goal is to discover new therapeutic targets that will allow them to reprogram metabolism in individuals at risk for Alzheimer’s Disease in order to enhance cognitive resilience and to extend the brain’s health span.



Related Research:

Apolipoprotein E and Immunometabolism in Alzheimer’s Disease Lance Johnson Josh Morganti Ramon Sun 2022-02-14

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Lee, S., Devanney, N. A., Golden, L. R., Smith, C. T., Schwartz, J. L., Walsh, A. E., Clarke, H. A., Goulding, D. S., Allenger, E. J., Morillo-Segovia, G., Friday, C. M., Gorman, A. A., Hawkinson, T. R., MacLean, S. M., Williams, H. C., Sun, R. C., Morganti, J. M., & Johnson, L. A. APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge, Cell Reports, March 3, 2023, Read More

Golden, L. R., & Johnson, L. A. Liver-ing in your head rent free: peripheral ApoE4 drives CNS pathology, Molecular Neurodegeneration, October 4, 2022, Read More

Yassine, H. N., Self, W., Kerman, B. E., Santoni, G., Navalpur Shanmugam, N., Abdullah, L., Golden, L. R., Fonteh, A. N., Harrington, M. G., Gräff, J., Gibson, G. E., Kalaria, R., Luchsinger, J. A., Feldman, H. H., Swerdlow, R. H., Johnson, L. A., Albensi, B. C., Zlokovic, B. V., Tanzi, R., Cunnane, S., … Bowman, G. L. Nutritional metabolism and cerebral bioenergetics in Alzheimer’s disease and related dementias, Alzheimer's & Dementia, December 8, 2022, Read More