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Seiko Ikezu, M.D.

Assistant Professor, Associate Consultant I, Department of Neuroscience, Mayo Clinic, Jacksonville

Assistant Professor Seiko Ikezu, M.D., is an Associate Consultant I at the Department of Neuroscience at the Mayo Clinic in Jacksonville, Florida. She graduated from Gunma University School of Medicine in Japan and took a position as a research assistant professor at Boston University before moving to the Mayo Clinic.  Dr. Ikezu’s research focuses on the pathophysiology of Alzheimer’s disease and autism spectrum disorders, with a special interest in the role of microglia in disease spread and neuronal development. Her main goal is to establish microglia-specific delivery of antisense oligonucleotide or recombinant lentivirus to target disease spread and altered neuronal network caused by microglial phenotypic change during aging or fetal phase. She published her work about the beneficial effect of microglial depletion on suppressing tau propagation in animal models of Alzheimer’s disease and microglial repopulation in the behavioral outcome of the maternal immune activation mouse model.

Dr. Ikezu’s faculty bio at Mayo Clinic

Related Research:

Targeting Microglial TSG101 for Synaptic Protection and Cognitive Enhancement in Alzheimer’s Disease Seiko Ikezu Tsuneya Ikezu 2022-02-14

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Targeting Microglial TSG101 for Synaptic Protection and Cognitive Enhancement in Alzheimer’s Disease 2021, 2023

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Xu, S., Zhang, Z., Melvin, B. C., Basu Ray, N., Ikezu, S., & Ikezu, T. Comparison of nanoimaging and nanoflow based detection of extracellular vesicles at a single particle resolution, Journal of Extracellular biology, October 16, 2024, Read More

Abdullah, M., Ruan, Z., Ikezu, S., & Ikezu, T. P2RX7 plays a critical role in extracellular vesicle‐mediated secretion of pathogenic molecules from microglia and astrocytes, Journal of Extracellular Biology, June 26, 2024, Read More

Yukawa, K., Yamamoto-Mcguire, S., Cafaro, L., Hong, C., Kamme, F., Ikezu, T., & Ikezu, S. Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice, Acta Neuropathologica Communications, October 19, 2023, Read More

You, Y., Zhang, Z., Sultana, N., Ericsson, M., Martens, Y. A., Sun, M., Kanekiyo, T., Ikezu, S., Shaffer, S. A., & Ikezu, T. ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids, Science Advances, September 15, 2023, Read More

Ruan, Z., Takamatsu-Yukawa, K., Wang, Y., Ushman, M. L., Labadorf, A. T., Ericsson, M., Ikezu, S., & Ikezu, T. Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia, Cell Reports, May 10, 2022, Read More

Zhang, Z., Yu, K., You, Y., Jiang, P., Wu, Z., DeTure, M. A., Dickson, D. W., Ikezu, S., Peng, J., & Ikezu, T. Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications, Journal of Extracellular Vesicles, August 10, 2023, Read More

Shi, H., Yin, Z., Koronyo, Y., Fuchs, D. T., Sheyn, J., Davis, M. R., Wilson, J. W., Margeta, M. A., Pitts, K. M., Herron, S., Ikezu, S., Ikezu, T., Graham, S. L., Gupta, V. K., Black, K. L., Mirzaei, M., Butovsky, O., & Koronyo-Hamaoui, M. Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia, Acta Neuropathologica Communications, September 8, 2022, Read More

Yin, Z., Herron, S., Silveira, S., Kleemann, K., ... Ikezu, S., Ikezu, T., Butovsky, O. Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease, Nature Neuroscience, June 8, 2023, Read More

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