Cure Alzheimer's Fund Cure Alzheimer's Fund

Laura Santambrogio, M.D., Ph.D.

Associate Director, Precision Immunology, Englander Institute of Precision Medicine; Professor, Radiation Oncology; Professor, Physiology and Biophysics;  Weill Cornell Medicine

Dr. Laura Santambrogio received her Ph.D. from Padua University and trained as a post-doctoral fellow at NYU and Harvard Medical School with Jack Strominger.  She was recruited at Albert Einstein College of Medicine with an Irene Diamond Professorship in Immunology and recently moved to Weill Cornell where she held the position of Associate Director of Precision Immunology in the Englander Institute of Precision Medicine, Professor of Radiation Oncology, Physiology and Biophysics. Current efforts in her laboratory are focused on the mechanisms of antigen processing and presentation, peptide binding to MHC class II molecules, and the overall role of dendritic cells in innate and adaptive immune responses. She is tackling these questions using an integrated approach that combines cell biology, biochemistry, and biophysics. Important questions addressed by her laboratory relates to the different cellular pathways utilized for antigen processing and presentation which include autophagy, endosomal processing, and surface MHC II loading. Additionally, she is interested in understanding how changes in the cellular transcriptome and metabolome translate in the plasticity of the MHC II immunopeptidome.

 

Related Research:

Brain Entry and Exit Consortium: Biochemical and Functional Analysis of Cerebrospinal Fluid and Lymph Following Changes in Brain Fluid Dynamics Laura Santambrogio 2022-05-03 Brain Entry and Exit Consortium: Lymphatics and Central Nervous System Fluid Homeostasis Laura Santambrogio 2022-02-15

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Brain Entry and Exit Consortium: Biochemical and Functional Analysis of Cerebrospinal Fluid and Lymph Following Changes in Brain Fluid Dynamics 2022, 2023

$575,000
Brain Entry and Exit Consortium: Lymphatics and Central Nervous System Fluid Homeostasis 2021

$172,500

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Gursky, Z. H., Khan, Z. N., Koundal, S., Bhardwaj, A., Caceres Melgarejo, J., Xu, K., Chen, X., Lin, H. M., Gu, X., Lee, H., Kipnis, J., Dori, Y., Tannenbaum, A., Santambrogio, L., & Benveniste, H. Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model, The Journal of Clinical Investigation, July 15, 2025, Read More

Nanaware, P. P., Khan, Z. N., Clement, C. C., Shetty, M., Mota, I., Seltzer, E. S., Dzieciatkowska, M., Gamboni, F., D'Alessandro, A., Ng, C., Nagayama, M., Lichti, C. F., Soni, R. K., Jacob B Geri, Matei, I., Lyden, D., Longman, R., Lu, T. T., Wan, X., Unanue, E. R., … Santambrogio, L. Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load, Cell Reports, June 25, 2024, Read More

Stern, L. J., Clement, C., Galluzzi, L., & Santambrogio, L. Non-mutational neoantigens in disease, Nature Immunology, January 2, 2024, Read More

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