In the central nervous system (CNS), the lymphatic system, together with the glymphatic system, controls fluid and waste disposal. As such, meningeal lymphatics are pivotal for maintaining fluid balance and, overall, a healthy brain. Our goal is to characterize the molecular mechanisms regulating the CNS lymphatic system by studying newly identified molecular players that regulate its function. Once completed, our studies will have characterized the proteins/molecules that regulate fluid and waste disposal in the brain. These studies will help uncover and potentially harness mechanisms that facilitate brain fluid clearance that is beneficial for preventing cognitive dysfunction.