Li-Huei Tsai, Ph.D.

Director, The Picower Institute for Learning and Memory and Picower Professor of Neuroscience, Department of Brain and Cognitive Sciences, Massachusetts General Hospital. Senior Associate Member, Broad Institute

Professor Tsai is a leader in understanding the molecular pathophysiology of neurological disorders affecting cognition. Her work has brought new mechanisms for learning, memory and neurodegeneration to light and suggests new paths for combatting age-related memory loss.

Landmark discoveries include pinpointing major genetic risk for Alzheimer’s disease to immune genes, identifying chromatin-modifiers and kinases that regulate brain flexibility and can be targeted to improve cognition in Alzheimer’s disease, and discovering that genomic integrity is critical for neuronal protection during both aging and neurodegenerative disease.

In 2019, Dr. Tsai won the Hans Wigzell Prize in Medicine for 2018 for her innovative research in trying to understand the etiology and possible treatment of Alzheimer’s disease.  She is a recipient of the Young Investigator Award, Metropolitan Life Foundation, Outstanding Contributor Award of the Alzheimer Research Forum, the NIH Cantoni Lecture Award and the Glenn Award For Research in Biological Mechanisms of Aging.

She is a Fellow of the American Association for the Advancement of Science and a member of the Institute of Medicine of the National Academy of Sciences, the Neurodegeneration Consortium and Taiwan’s Academia Sinica.

Dr. Tsai has authored and co-authored over 130 peer-reviewed articles published in Nature, Cell, Neuron, Molecular Psychiatry, The Journal of Neuroscience, Nature Neuroscience, and the Proceedings of the National Academy of Sciences.  Her research has been featured in National Geographic and the Boston Globe.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, Edward S. Boyden Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, Cell, 169(6), 1 Jun 2017, 1029-1041, Read More

L Ashley Watson, Li-Huei Tsai In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory, Current Opinion in Neurobiology, 43, April 2017, 48-55, Read More

Rebecca G. Canter, Jay Penney, and Li-Huei Tsai The road to restoring neural circuits for the treatment of Alzheimer’s disease, Nature, 539(7628), 10 Nov 2016, 187–196, Read More