Oskar Hansson, M.D., Ph.D.

Principal Investigator, Professor, Research Team Manager, Clinical Memory Research, Lund University, Sweden


Dr. Oskar Hansson gained his Ph.D. in neurobiology in 2001 and his M.D. in 2005. He became a senior consultant in neurology in 2012 at Skåne University Hospital, and a full professor of neurology in 2017 at Lund University, Sweden. Oskar Hansson performs internationally recognized clinical and translational research focusing on the early phases of Alzheimer’s and Parkinson’s diseases. His work on biomarkers has led to over 350 original peer-reviewed publications. He heads the prospective and longitudinal Swedish BioFINDER studies (www.biofinder.se), where the research team focuses on the development of optimized diagnostic algorithms for early diagnosis, and also studies the consequences of different brain pathologies on cognitive, neurologic, and psychiatric symptoms in healthy individuals and patients with dementia and parkinsonian disorders. Recently, the BioFINDER team has shown that Tau PET imaging can reliably distinguish Alzheimer’s from other neurodegenerative diseases (JAMA, 2018) and to detect different subtypes of Alzheimer’s (Nature Medicine 2021), and the team has validated blood-based biomarkers for early detection of Alzheimer’s disease (Nature Medicine, 2020; JAMA, 2020, Nature Aging 2021, Nature Medicine 2021). He is the co-director of the strategic research area of neuroscience at Lund University, and responsible for research at the Memory Clinic at Skåne University Hospital.

@RikOssenkoppele, @biofinder_study

 

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Karlsson, L., Vogel, J., Arvidsson, I., Åström, K., Janelidze, S., Blennow, K., Palmqvist, S., Stomrud, E., Mattsson-Carlgren, N., & Hansson, O. Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases, Nature Communications, May 1, 2024, Read More

Ahmadi, K., Pereira, J. B., Westen, D. V., Pasternak, O., Zhang, F., Nilsson, M., Stomrud, E., Spotorno, N., & Hansson, O. Fixel-based analysis reveals tau-related white matter changes in early stages of Alzheimer’s disease, The Journal of Neuroscience, April 2, 2024, Read More

Salvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J., & Hansson, O. Disease staging of Alzheimer’s disease using a CSF-based biomarker model, Nature Aging, March 21, 2024, Read More

Arvidsson, I., Strandberg, O., Palmqvist, S., Stomrud, E., Cullen, N., Janelidze, S., Tideman, P., Heyden, A., Åström, K., Hansson, O., & Mattsson-Carlgren, N. Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms, Alzheimer's Research & Therapy, March 19, 2024, Read More

Brum, W. S., Cullen, N. C., Therriault, J., Janelidze, S., Rahmouni, N., Stevenson, J., Servaes, S., Benedet, A. L., Zimmer, E. R., Stomrud, E., Palmqvist, S., Zetterberg, H., Frisoni, G. B., Ashton, N. J., Blennow, K., Mattsson-Carlgren, N., Rosa-Neto, P., & Hansson, O. A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings, Nature Communications, March 14, 2024, Read More

Barthélemy, N. R., Salvadó, G., Schindler, S., He, Y., Janelidze, S., Collij, L. E., Saef, B., Henson, R. L., Chen, C. D., Gordon, B. A., Li, Y., La Joie, R., Benzinger, T. L. S., Morris, J. C., Mattsson-Carlgren, N., Palmqvist, S., Ossenkoppele, R., Rabinovici, G. D., Stomrud, E., Bateman, R. J. & Hansson, O. Highly Accurate Blood Test for Alzheimer’s Disease Comparable or Superior to Clinical CSF Tests, Nature Medicine, February 21, 2024, Read More

Wennström, M., Schultz, N., Gallardo, P. M., The Netherlands Brain Bank, Serrano, G. E., Beach, T. G., Bose, S., & Hansson, O. The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer’s Disease Pathology, Cells, February 11, 2024, Read More

Bali, D., Hansson, O., & Janelidze, S. Effects of certain pre-analytical factors on the performance of plasma phospho-tau217, Alzheimer's Research & Therapy, February 8, 2024, Read More

Nilsson, J., Pichet Binette, A., Palmqvist, S., Brum, W. S., Janelidze, S., Ashton, N. J., Spotorno, N., Stomrud, E., Gobom, J., Zetterberg, H., Brinkmalm, A., Blennow, K., & Hansson, O. Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases, Brain, February 7, 2024, Read More

Spotorno, N., Najac, C., Strandberg, O., Stomrud, E., van Westen, D., Nilsson, M., Ronen, I., & Hansson, O. Diffusion weighted magnetic resonance spectroscopy revealed neuronal specific microstructural alterations in Alzheimer’s disease, Brain Communications, February 1, 2024, Read More

Young, A. L., Vogel, J. W., Robinson, J. L., McMillan, C. T., Ossenkoppele, R., Wolk, D. A., Irwin, D. J., Elman, L., Grossman, M., Lee, V. M., Lee, E. B., & Hansson, O. Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies, Brain, May 8, 2023, Read More

Coomans, E. M., van Westen, D., Pichet Binette, A., Strandberg, O., Spotorno, N., Serrano, G. E., Beach, T. G., Palmqvist, S., Stomrud, E., Ossenkoppele, R., & Hansson, O. Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation, Brain, September 18, 2023, Read More

Bocancea, D. I., Svenningsson, A. L., van Loenhoud, A. C., Groot, C., Barkhof, F., Strandberg, O., Smith, R., Alzheimer’s Disease Neuroimaging Initiative, La Joie, R., Rosen, H. J., Pontecorvo, M. J., Rabinovici, G. D., van der Flier, W. M., Hansson, O., & Ossenkoppele, R. Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis, Brain, March 27, 2023, Read More

Zheng, L., Rubinski, A., Denecke, J., Luan, Y., Smith, R., Strandberg, O., Stomrud, E., Ossenkoppele, R., Svaldi, D. O., Higgins, I. A., Shcherbinin, S., Pontecorvo, M. J., Hansson, O., Franzmeier, N., Ewers, M., & Alzheimer's Disease Neuroimaging Initiative Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease, Annals of Neurology, October 14, 2023, Read More

Hansson, O., Blennow, K., Zetterberg, H., & Dage, J. Blood biomarkers for Alzheimer’s disease in clinical practice and trials, Nature Aging, May 18, 2023, Read More

Brand, A. L., Lawler, P. E., Bollinger, J. G., Li, Y., Schindler, S. E., Li, M., Lopez, S., Ovod, V., Nakamura, A., Shaw, L. M., Zetterberg, H., Hansson, O., & Bateman, R. J. The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature review, Alzheimer's Research & Therapy, December 27, 2022, Read More

Van Egroo, M., Riphagen, J. M., Ashton, N. J., Janelidze, S., Sperling, R. A., Johnson, K. A., Yang, H. S., Bennett, D. A., Blennow, K., Hansson, O., Zetterberg, H., & Jacobs, H. I. L. Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau, Molecular Psychiatry, April 5, 2023, Read More

Quadalti, C., Palmqvist, S., Hall, S., Rossi, M., Mammana, A., Janelidze, S., Dellavalle, S., Mattsson-Carlgren, N., Baiardi, S., Stomrud, E., Hansson, O., & Parchi, P. Clinical effects of Lewy body pathology in cognitively impaired individuals, Nature Medicine, July 18, 2023, Read More

Palmqvist, S., Rossi, M., Hall, S., Quadalti, C., Mattsson-Carlgren, N., Dellavalle, S., Tideman, P., Pereira, J. B., Nilsson, M. H., Mammana, A., Janelidze, S., Baiardi, S., Stomrud, E., Parchi, P., & Hansson, O. Cognitive effects of Lewy body pathology in clinically unimpaired individuals, Nature Medicine, July 18, 2023, Read More

Smith, R., Capotosti, F., Schain, M., Ohlsson, … Hansson, O. The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases, Nature Communications, October 27, 2023, Read More

Pereira, J. B., Kumar, A., Hall, S., Palmqvist, S., Stomrud, E., Bali, D., Parchi, P., Mattsson-Carlgren, N., Janelidze, S., & Hansson, O. DOPA decarboxylase is an emerging biomarker for Parkinsonian disorders including preclinical Lewy body disease, Nature Aging, September 18, 2023, Read More

Brum, W. S., Cullen, N. C., Janelidze, S., Ashton, N. J., Zimmer, E. R., Therriault, J., Benedet, A. L., Rahmouni, N., Tissot, C., Stevenson, J., Servaes, S., Triana-Baltzer, G., Kolb, H. C., Palmqvist, S., Stomrud, E., Rosa-Neto, P., Blennow, K., & Hansson, O. A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases, Nature Aging, August 31, 2023, Read More

Pocevičiūtė, D., Roth, B., Schultz, N., Nuñez-Diaz, C., Janelidze, S., The Netherl|s Brain Bank, Olofsson, A., Hansson, O., & Wennström, M. Plasma IAPP-Autoantibody Levels in Alzheimer’s Disease Patients Are Affected by APOE4 Status, International Journal of Molecular Sciences, February 14, 2023, Read More

Kuchcinski, G., Rumetshofer, T., Zervides, K. A., Lopes, R., Gautherot, M., Pruvo, J. P., Bengtsson, A. A., Hansson, O., Jönsen, A., & Sundgren, P. C. M. MRI BrainAGE demonstrates increased brain aging in systemic lupus erythematosus patients, Frontiers in Aging Neuroscience, October 20, 2023, Read More

Harper, L., de Boer, S., Lindberg, O., Lätt, J., Cullen, N., Clark, L., Irwin, D., Massimo, L., Grossman, M., Hansson, O., Pijnenburg, Y., McMillan, C. T., & Santillo, A. F. Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia, Brain Communications, October 10, 2023, Read More

Spotorno, N., Strandberg, O., Stomrud, E., Janelidze, S., Blennow, K., Nilsson, M., van Westen, D., & Hansson, O. Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer’s disease, Brain, December 21, 2023, Read More

Wuestefeld, A., Pichet Binette, A., Berron, D., Spotorno, N., van Westen, D., Stomrud, E., Mattsson-Carlgren, N., Str|berg, O., Smith, R., Palmqvist, S., Glenn, T., Moes, S., Honer, M., Arfanakis, K., Barnes, L. L., Bennett, D. A., Schneider, J. A., Wisse, L. E. M., & Hansson, O. Age-related and amyloid-beta-independent tau deposition and its downstream effects, Brain, April 21, 2023, Read More

Oeckl, P., Janelidze, S., Halbgebauer, S., Stomrud, E., Palmqvist, S., Otto, M., & Hansson, O. Higher plasma beta-synuclein indicates early synaptic degeneration in Alzheimer’s disease, Alzheimer's & Dementia, April 27, 2023, Read More

Barthélemy, N. R., Saef, B., Li, Y., Gordon, B. A., He, Y., Horie, K., Stomrud, E., Salvadó, G., Janelidze, S., Sato, C., Ovod, V., Henson, R. L., Fagan, A. M., Benzinger, T. L. S., Xiong, C., Morris, J. C., Hansson, O., Bateman, R. J., & Schindler, S. E. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease, Nature Aging, March 13, 2023, Read More

Horie, K., Salvadó, G., Barthélemy, N. R., Janelidze, S., Li, Y., He, Y., Saef, B., Chen, C. D., Jiang, H., Strandberg, O., Pichet Binette, A., Palmqvist, S., Sato, C., Sachdev, P., Koyama, A., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Mattsson-Carlgren, N., … Bateman, R. J. CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease, Nature Medicine, July 13, 2023, Read More

Brum, W. S., Docherty, K. F., Ashton, N. J., Zetterberg, H., Hansson, O., McMurray, J. J. V., & Blennow, K. Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers: A Secondary Analysis of a Randomized Clinical Trial, JAMA Neurology, December 18, 2023, Read More

Mattsson-Carlgren, N., Collij, L. E., Stomrud, E., Pichet Binette, A., Ossenkoppele, R., Smith, R., Karlsson, L., Lantero-Rodriguez, J., Snellman, A., Strandberg, O., Palmqvist, S., Ashton, N. J., Blennow, K., Janelidze, S., & Hansson, O. Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies, JAMA Neurology, December 4, 2023, Read More

Smith, R., Hägerström, D., Pawlik, D., Klein, G., Jögi, J., Ohlsson, T., Stomrud, E., & Hansson, O. Clinical Utility of Tau Positron Emission Tomography in the Diagnostic Workup of Patients With Cognitive Symptoms, JAMA Neurology, May 22, 2023, Read More