These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Characterization of Tau Pathology Heterogeneity Across the Alzheimer’s Disease Spectrum |
2022, 2023 $402,500 |
These published papers resulted from Cure Alzheimer’s Fund support.
Ahmadi, K., Pereira, J. B., Westen, D. V., Pasternak, O., Zhang, F., Nilsson, M., Stomrud, E., Spotorno, N., & Hansson, O. Fixel-based analysis reveals tau-related white matter changes in early stages of Alzheimer’s disease, The Journal of Neuroscience, April 2, 2024, Read More
Salvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J., & Hansson, O. Disease staging of Alzheimer’s disease using a CSF-based biomarker model, Nature Aging, March 21, 2024, Read More
Arvidsson, I., Strandberg, O., Palmqvist, S., Stomrud, E., Cullen, N., Janelidze, S., Tideman, P., Heyden, A., Åström, K., Hansson, O., & Mattsson-Carlgren, N. Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms, Alzheimer's Research & Therapy, March 19, 2024, Read More
Brum, W. S., Cullen, N. C., Therriault, J., Janelidze, S., Rahmouni, N., Stevenson, J., Servaes, S., Benedet, A. L., Zimmer, E. R., Stomrud, E., Palmqvist, S., Zetterberg, H., Frisoni, G. B., Ashton, N. J., Blennow, K., Mattsson-Carlgren, N., Rosa-Neto, P., & Hansson, O. A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings, Nature Communications, March 14, 2024, Read More
Barthélemy, N. R., Salvadó, G., Schindler, S., He, Y., Janelidze, S., Collij, L. E., Saef, B., Henson, R. L., Chen, C. D., Gordon, B. A., Li, Y., La Joie, R., Benzinger, T. L. S., Morris, J. C., Mattsson-Carlgren, N., Palmqvist, S., Ossenkoppele, R., Rabinovici, G. D., Stomrud, E., Bateman, R. J. & Hansson, O. Highly Accurate Blood Test for Alzheimer’s Disease Comparable or Superior to Clinical CSF Tests, Nature Medicine, February 21, 2024, Read More
Wennström, M., Schultz, N., Gallardo, P. M., The Netherlands Brain Bank, Serrano, G. E., Beach, T. G., Bose, S., & Hansson, O. The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer’s Disease Pathology, Cells, February 11, 2024, Read More
Bali, D., Hansson, O., & Janelidze, S. Effects of certain pre-analytical factors on the performance of plasma phospho-tau217, Alzheimer's Research & Therapy, February 8, 2024, Read More
Nilsson, J., Pichet Binette, A., Palmqvist, S., Brum, W. S., Janelidze, S., Ashton, N. J., Spotorno, N., Stomrud, E., Gobom, J., Zetterberg, H., Brinkmalm, A., Blennow, K., & Hansson, O. Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases, Brain, February 7, 2024, Read More
Spotorno, N., Najac, C., Strandberg, O., Stomrud, E., van Westen, D., Nilsson, M., Ronen, I., & Hansson, O. Diffusion weighted magnetic resonance spectroscopy revealed neuronal specific microstructural alterations in Alzheimer’s disease, Brain Communications, February 1, 2024, Read More
Young, A. L., Vogel, J. W., Robinson, J. L., McMillan, C. T., Ossenkoppele, R., Wolk, D. A., Irwin, D. J., Elman, L., Grossman, M., Lee, V. M., Lee, E. B., & Hansson, O. Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies, Brain, May 8, 2023, Read More
Coomans, E. M., van Westen, D., Pichet Binette, A., Strandberg, O., Spotorno, N., Serrano, G. E., Beach, T. G., Palmqvist, S., Stomrud, E., Ossenkoppele, R., & Hansson, O. Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation, Brain, September 18, 2023, Read More
Bocancea, D. I., Svenningsson, A. L., van Loenhoud, A. C., Groot, C., Barkhof, F., Strandberg, O., Smith, R., Alzheimer’s Disease Neuroimaging Initiative, La Joie, R., Rosen, H. J., Pontecorvo, M. J., Rabinovici, G. D., van der Flier, W. M., Hansson, O., & Ossenkoppele, R. Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis, Brain, March 27, 2023, Read More
Zheng, L., Rubinski, A., Denecke, J., Luan, Y., Smith, R., Strandberg, O., Stomrud, E., Ossenkoppele, R., Svaldi, D. O., Higgins, I. A., Shcherbinin, S., Pontecorvo, M. J., Hansson, O., Franzmeier, N., Ewers, M., & Alzheimer's Disease Neuroimaging Initiative Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease, Annals of Neurology, October 14, 2023, Read More
Hansson, O., Blennow, K., Zetterberg, H., & Dage, J. Blood biomarkers for Alzheimer’s disease in clinical practice and trials, Nature Aging, May 18, 2023, Read More
Brand, A. L., Lawler, P. E., Bollinger, J. G., Li, Y., Schindler, S. E., Li, M., Lopez, S., Ovod, V., Nakamura, A., Shaw, L. M., Zetterberg, H., Hansson, O., & Bateman, R. J. The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature review, Alzheimer's Research & Therapy, December 27, 2022, Read More
Quadalti, C., Palmqvist, S., Hall, S., Rossi, M., Mammana, A., Janelidze, S., Dellavalle, S., Mattsson-Carlgren, N., Baiardi, S., Stomrud, E., Hansson, O., & Parchi, P. Clinical effects of Lewy body pathology in cognitively impaired individuals, Nature Medicine, July 18, 2023, Read More
Palmqvist, S., Rossi, M., Hall, S., Quadalti, C., Mattsson-Carlgren, N., Dellavalle, S., Tideman, P., Pereira, J. B., Nilsson, M. H., Mammana, A., Janelidze, S., Baiardi, S., Stomrud, E., Parchi, P., & Hansson, O. Cognitive effects of Lewy body pathology in clinically unimpaired individuals, Nature Medicine, July 18, 2023, Read More
Smith, R., Capotosti, F., Schain, M., Ohlsson, … Hansson, O. The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases, Nature Communications, October 27, 2023, Read More
Pereira, J. B., Kumar, A., Hall, S., Palmqvist, S., Stomrud, E., Bali, D., Parchi, P., Mattsson-Carlgren, N., Janelidze, S., & Hansson, O. DOPA decarboxylase is an emerging biomarker for Parkinsonian disorders including preclinical Lewy body disease, Nature Aging, September 18, 2023, Read More
Brum, W. S., Cullen, N. C., Janelidze, S., Ashton, N. J., Zimmer, E. R., Therriault, J., Benedet, A. L., Rahmouni, N., Tissot, C., Stevenson, J., Servaes, S., Triana-Baltzer, G., Kolb, H. C., Palmqvist, S., Stomrud, E., Rosa-Neto, P., Blennow, K., & Hansson, O. A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases, Nature Aging, August 31, 2023, Read More
Van Egroo, M., Riphagen, J. M., Ashton, N. J., Janelidze, S., Sperling, R. A., Johnson, K. A., Yang, H. S., Bennett, D. A., Blennow, K., Hansson, O., Zetterberg, H., & Jacobs, H. I. L. Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau, Molecular Psychiatry, April 5, 2023, Read More
Pocevičiūtė, D., Roth, B., Schultz, N., Nuñez-Diaz, C., Janelidze, S., The Netherl|s Brain Bank, Olofsson, A., Hansson, O., & Wennström, M. Plasma IAPP-Autoantibody Levels in Alzheimer’s Disease Patients Are Affected by APOE4 Status, International Journal of Molecular Sciences, February 14, 2023, Read More
Kuchcinski, G., Rumetshofer, T., Zervides, K. A., Lopes, R., Gautherot, M., Pruvo, J. P., Bengtsson, A. A., Hansson, O., Jönsen, A., & Sundgren, P. C. M. MRI BrainAGE demonstrates increased brain aging in systemic lupus erythematosus patients, Frontiers in Aging Neuroscience, October 20, 2023, Read More
Harper, L., de Boer, S., Lindberg, O., Lätt, J., Cullen, N., Clark, L., Irwin, D., Massimo, L., Grossman, M., Hansson, O., Pijnenburg, Y., McMillan, C. T., & Santillo, A. F. Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia, Brain Communications, October 10, 2023, Read More
Spotorno, N., Strandberg, O., Stomrud, E., Janelidze, S., Blennow, K., Nilsson, M., van Westen, D., & Hansson, O. Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer’s disease, Brain, December 21, 2023, Read More
Wuestefeld, A., Pichet Binette, A., Berron, D., Spotorno, N., van Westen, D., Stomrud, E., Mattsson-Carlgren, N., Str|berg, O., Smith, R., Palmqvist, S., Glenn, T., Moes, S., Honer, M., Arfanakis, K., Barnes, L. L., Bennett, D. A., Schneider, J. A., Wisse, L. E. M., & Hansson, O. Age-related and amyloid-beta-independent tau deposition and its downstream effects, Brain, April 21, 2023, Read More
Oeckl, P., Janelidze, S., Halbgebauer, S., Stomrud, E., Palmqvist, S., Otto, M., & Hansson, O. Higher plasma beta-synuclein indicates early synaptic degeneration in Alzheimer’s disease, Alzheimer's & Dementia, April 27, 2023, Read More
Barthélemy, N. R., Saef, B., Li, Y., Gordon, B. A., He, Y., Horie, K., Stomrud, E., Salvadó, G., Janelidze, S., Sato, C., Ovod, V., Henson, R. L., Fagan, A. M., Benzinger, T. L. S., Xiong, C., Morris, J. C., Hansson, O., Bateman, R. J., & Schindler, S. E. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease, Nature Aging, March 13, 2023, Read More
Horie, K., Salvadó, G., Barthélemy, N. R., Janelidze, S., Li, Y., He, Y., Saef, B., Chen, C. D., Jiang, H., Strandberg, O., Pichet Binette, A., Palmqvist, S., Sato, C., Sachdev, P., Koyama, A., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Mattsson-Carlgren, N., … Bateman, R. J. CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease, Nature Medicine, July 13, 2023, Read More
Brum, W. S., Docherty, K. F., Ashton, N. J., Zetterberg, H., Hansson, O., McMurray, J. J. V., & Blennow, K. Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers: A Secondary Analysis of a Randomized Clinical Trial, JAMA Neurology, December 18, 2023, Read More
Mattsson-Carlgren, N., Collij, L. E., Stomrud, E., Pichet Binette, A., Ossenkoppele, R., Smith, R., Karlsson, L., Lantero-Rodriguez, J., Snellman, A., Strandberg, O., Palmqvist, S., Ashton, N. J., Blennow, K., Janelidze, S., & Hansson, O. Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies, JAMA Neurology, December 4, 2023, Read More
Smith, R., Hägerström, D., Pawlik, D., Klein, G., Jögi, J., Ohlsson, T., Stomrud, E., & Hansson, O. Clinical Utility of Tau Positron Emission Tomography in the Diagnostic Workup of Patients With Cognitive Symptoms, JAMA Neurology, May 22, 2023, Read More