P. Murali Doraiswamy, M.B.B.S.

Professor of Psychiatry and Behavioral Sciences; Director, Neurocognitive Disorders Program;
Professor in Medicine, Duke University

Dr. Murali Doraiswamy is a Professor of Psychiatry and Professor in Medicine at the Duke University School of Medicine as well as Director of the Neurocognitive Disorders Program in the Department of Psychiatry at Duke University Medical Center. He also serves on the Executive Committee of the Duke Institute for Brain Sciences and as a Senior Fellow at the Duke Center for the Study of Aging. Dr. Doraiswamy directs a leading clinical trials unit that has been involved in the development of many of the leading products used today to treat cognitive and neuropsychiatric conditions. He is also widely recognized for his work in the study of imaging biomarkers (such as MRI volumetrics, amyloid PET and functional MRI). Dr. Doraiswamy is a Fellow of the Royal College of Physicians (London), a Fellow of the American Neurological Association and a member of the World Economic Forum’s Global Agenda Council on Brain Research. He also serves as an advisor to leading government agencies, biotech and health companies, and patient advocacy groups. Dr. Doraiswamy is a brain health advisor for Men’s Health magazine and serves as an Alzheimer’s advisor for AARP. He is co-author of a popular book, The Alzheimer’s Action Plan.




Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Ding, H., Liu, C., Li, Y., Ang, T. F. A., Devine, S., Liu, Y., Au, R., & Doraiswamy, P. M. Sex‐specific blood biomarkers linked to memory changes in middle‐aged adults: The Framingham Heart Study, Alzheimer's & Dementia, March 27, 2024, Read More

Ding, H., Li, Y., Ang, T. F. A., Liu, Y., Devine, S., Au, R., Doraiswamy, P. M., & Liu, C. Reproductive Markers in Alzheimer’s Disease Progression: The Framingham Heart Study, Journal of Prevention of Alzheimer's Disease, March 22, 2023, Read More

Akushevich, I., Kravchenko, J., Yashkin, A., Doraiswamy, P. M., Hill, C. V., & Alzheimer's Disease and Related Dementia Health Disparities Collaborative Group. Expanding the scope of health disparities research in Alzheimer’s disease and related dementias, Alzheimer's & Dementia, March 16, 2023, Read More

Liu, C., Li, Y., Nwosu, A., Ang, T. F. A., Liu, Y., Devine, S., Au, R., & Doraiswamy, P. M. Sex‐specific biomarkers in Alzheimer’s disease progression: Framingham Heart Study, Alzheimer's & Dementia, November 3, 2022, Read More

Wang, Q., Davis, P. B., Qi, X., Chen, S. G., Gurney, M. E., Perry, G., Doraiswamy, P. M., & Xu, R. Gut-microbiota-microglia-brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization, Alzheimer's Research & Therapy, October 20, 2021, Read More

Bodner, K. A., Goldberg, T. E., Devanand, D. P., & Doraiswamy, P. M. Advancing Computerized Cognitive Training for MCI and Alzheimer’s Disease in a Pandemic and Post-pandemic World, Frontiers in Psychiatry, November 25, 2020, Read More

Sabbagh, M. N., Boada, M., Borson, S., Doraiswamy, P. M., Dubois, B., Ingram, J., Iwata, A., Porsteinsson, A. P., Possin, K. L., Rabinovici, G. D., Vellas, B., Chao, S., Vergallo, A., & Hampel, H. Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting, Journal of Prevention of Alzheimer's Disease, April 6, 2020, Read More

Sabbagh, M. N., Boada, M., Borson, S., Chilukuri, M., Doraiswamy, P. M., Dubois, B., Ingram, J., Iwata, A., Porsteinsson, A. P., Possin, K. L., Rabinovici, G. D., Vellas, B., Chao, S., Vergallo, A., & Hampel, H. Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) Supported by Emerging Digital Technologies, Journal of Prevention of Alzheimer's Disease, March 6, 2020, Read More

Arnold, M., Nho, K., Kueider-Paisley, A., Massaro, T., Huynh, K., Brauner, B., MahmoudianDehkordi, S., Louie, G., Moseley, M. A., Thompson, J. W., John-Williams, L. S., Tenenbaum, J. D., Blach, C., Chang, R., Brinton, R. D., Baillie, R., Han, X., Trojanowski, J. Q., Shaw, L. M., Martins, R., … Doraiswamy, P. M., ... Kastenmüller, G. Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome, Nature Communications, March 2, 2020, Read More

Petrella, J. R., Hao, W., Rao, A., & Doraiswamy, P. M. Computational Causal Modeling of the Dynamic Biomarker Cascade in Alzheimer’s Disease, Computational and Mathematical Methods in Medicine, February 3, 2019, Read More

Ong, S. S., Doraiswamy, P. M., & Lad, E. M. Controversies and Future Directions of Ocular Biomarkers in Alzheimer Disease, JAMA Neurology, June 1, 2018, Read More

Sohn, D., Shpanskaya, K., Lucas, J. E., Petrella, J. R., Saykin, A. J., Tanzi, R. E., Samatova, N. F., & Doraiswamy, P. M. Sex Differences in cognitive decline in subjects with high likelihood of mild cognitive impairments due to Alzheimer’s disease, Scientific Reports, May 10, 2018, Read More

Padmanabhan, K., Nudelman, K., Harenberg, S., Bello, G., Sohn, D., Shpanskaya, K., Tiwari Dikshit, P., Yerramsetty, P.S., Tanzi, R.E., Saykin, A.J., Petrella, J.R., Doraiswamy, P. M., Samatova, N. & Alzheimer's Disease Neuroimaging Initiative. Characterizing Gene and Protein Crosstalks in Subjects at risk of developing Alzheimer’s disease: a new computational approach, Processes, September 1, 2017, Read More

Gamberger, D., Lavrač, N., Srivatsa, S., Tanzi, R. E., & Doraiswamy, P. M. Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease, Scientific Reports, July 28, 2017, Read More

Hunsberger, J. G., Rao, M., Kurtzberg, J., Bulte, J. W. M., Atala, A., LaFerla, F. M., Greely, H. T., Sawa, A., Gandy, S., Schneider, L. S., & Doraiswamy, P. M. Accelerating Stem Cell Trials for Alzheimer’s Disease, Lancet Neurology, December 17, 2015, Read More