Randall J. Bateman, M.D.

Charles F. and Joanne Knight Distinguished Professor of Neurology; Director, Dominantly Inherited Alzheimer’s Network (DIAN) and DIAN Trials Unit (DIAN-TU); Washington University School of Medicine in St. Louis 

Dr. Bateman received a B.S. in Electrical Engineering and B.S. in Biology from Washington University and M.D. from Case Western Reserve University School of Medicine. He completed Neurology residency at Barnes Jewish Hospital and postdoctoral research at Washington University School of Medicine. Dr. Bateman is the Charles F. and Joanne Knight Distinguished Professor of Neurology, Director of the Dominantly Inherited Alzheimer Network (DIAN), and Director of the DIAN Trials Unit (DIAN-TU). Dr. Bateman’s research focuses on the pathophysiology and development of improved diagnostics and treatments of Alzheimer’s disease. Dr. Bateman’s lab accomplishments include pioneering the central nervous system Stable Isotope Labeling Kinetics (SILK) measurements in humans, furthering insights of human circadian patterns of amyloid-beta and soluble APP, and human in vivo control of the alpha-secretase, beta-secretase, and gamma-secretase processing of amyloid-beta.

His lab has developed methods to quantify the pharmacodynamic action of drugs targeting amyloid-beta, amyloid precursor protein, and Apolipoprotein E. Dr. Bateman’s research in DIAN has provided evidence for a cascade of events beginning decades before symptom onset that leads to AD dementia. He has received a number of awards including the Beeson Award for Aging Research, Alzheimer’s Association (Zenith Award), Scientific American, Chancellor’s Award for Innovation and Entrepreneurship (Washington University), the Glenn Award for Aging Research, and the MetLife Foundation Award for Medical Research. Dr. Bateman has been the primary mentor for junior faculty, clinical fellows, post-doctoral researchers, and graduate and medical students, who have been successful in their desired scientific careers.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Norelle C. Wildburger, Thomas J. Esparza, Richard D. LeDuc, Ryan T. Fellers, Paul M. Thomas, Nigel J. Cairns, Neil L. Kelleher, Randall J. Bateman, David L. Brody Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain, Scientific Reports, 7, 25 Aug 2017, Read More