These projects were made possible from Cure Alzheimer's Fund support.
|Berg Brain Entry and Exit Consortium: Human 3D Neurovascular Interaction and Meningeal Lymphatics Models with Application to Alzheimer’s Disease||
|Neuroprotective Effects of the Exercise Hormone Irisin in Alzheimer’s Disease||
|Evaluation of Blood-Brain Barrier (BBB) Penetration of Alzheimer’s Drug Targets, and Identification of BBB Integrity Enhancers||
|Role of Blood-Brain Barrier Function in Alzheimer’s Disease Pathogenesis Investigated Using a 3-D Microfluidic Platform||
2015 to 2016
|Exploring Adult Neurogenesis as a Therapeutic Target for Alzheimer’s Disease||
These published papers resulted from Cure Alzheimer’s Fund support.
Rudy Tanzi, Se Hoon Choi Exercise and Improved Cognition, Science , September 6, 2018, Read More
Carla D'Avanzo, Jenna Aronson, Young Hye Kim, Se Hoon Choi, Rudolph E. Tanzi and Doo Yeon Kim Alzheimer’s in 3D culture: Challenges and perspectives, BioEssays, 37(10), October 2015, 1139–1148, Read More
Jaehong Suh, Se Hoon Choi, Donna M. Romano, Moira A. Gannon, Andrea N. Lesinski, Doo Yeon Kim, Rudolph E. Tanzi ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function, Neuron, 80(2), Oct 16, 2013, 385–401, Read More
Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling, The Journal of Neuroscience, 30(20), May 19, 2010, 6903-6915, Read More
Choi SH, Li Y, Parada LF, Sisodia SS Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF, Mol Neurodegener, 4, Dec 21, 2009, 52, Read More
Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides, Angewandte Chemi International Edition, Volume 48 Issue 8, February 9, 2009, 1487–1489, Read More
Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation, Neuron, Volume 59, Issue 4, August 28, 2008, 568-580, Read More
Choi SH, Leight SN, Lee VM-Y, Li T, Wong PC, Johson JA, Saraiva MJ, Sisodia SS Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin), J Neurosci, (26), 6/27/2007, 7006-7010, Read More