Kim, E., Tanzi, R. E., & Choi, S. H. Therapeutic potential of exercise-hormone irisin in Alzheimer’s disease, Neural Regeneration Research, July 10, 2024, Read More

Bai, P., Lan, Y., Liu, Y., Mondal, P., Gomm, A., Xu, Y., Wang, Y., Wang, Y., Kang, L., Pan, L., Bagdasarian, F. A., Hallisey, M., Varela, B., Choi, S. H., Gomperts, S. N., Wey, H. Y., Shen, S., Tanzi, R. E., Wang, C., & Zhang, C. Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer’s Disease, Advanced Science, June 25, 2024, Read More

Kwak, S. S., Washicosky, K. J., Brand, E., von Maydell, D., Aronson, J., Kim, S., Capen, D. E., Cetinbas, M., Sadreyev, R., Ning, S., Bylykbashi, E., Xia, W., Wagner, S. L., Choi, S. H., Tanzi, R. E., & Kim, D. Y. Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease, Nature Communications, March 13, 2020, Read More

Choi, S. H., Li, Y., Parada, L. F., & Sisodia, S. S. Regulation of hippocampal progenitor cell survival, proliferation, and dendritic development by BDNF, Molecular Neurodegeneration, December 21, 2009, Read More

Meier, M., Kennedy-Darling, J., Choi, S. H., Norstrom, E. M., Sisodia, S. S., & Ismagilov, R. F. Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides, Angewandte Chemie (International ed. in English), January 30, 2009, Read More

Choi, S. H., Bylykbashi, E., Chatila, Z. K., Lee, S. W., Pulli, B., Clemenson, G. D., Kim, E., Rompala, A., Oram, M. K., Asselin, C., Aronson, J., Zhang, C., Miller, S. J., Lesinski, A., Chen, J. W., Kim, D. Y., van Praag, H., Spiegelman, B. M., Gage, F. H., & Tanzi, R. E. Combined Adult Neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model, Science, September 7, 2018, Read More

Choi, S. H., Kim, Y. H., Quinti, L., Tanzi, R. E., & Kim, D. Y. 3D Culture Models of Alzheimer’s disease: a road map to a “cure-in-a-dish”, Molecular Neurodegeneration, December 9, 2016, Read More

Wang, Z., Ye, J., Zhang, K., Ding, L., Granzier-Nakajima, T., Ranasinghe, J. C., Xue, Y., Sharma, S., Biase, I., Terrones, M., Choi, S. H., Ran, C., Tanzi, R. E., Huang, S. X., Zhang, C., & Huang, S. Rapid Biomarker Screening of Alzheimer’s Disease by Interpretable Machine Learning and Graphene-Assisted Raman Spectroscopy, ASC Nano, March 25, 2022, Read More

Islam, M. R., Valaris, S., Young, M. F., Haley, E. B., Luo, R., Bond, S. F., Mazuera, S., Kitchen, R. R., Caldarone, B. J., Bettio, L. E. B., Christie, B. R., Schmider, A. B., Soberman, R. J., Besnard, A., Jedrychowski, M. P., Kim, H., Tu, H., Kim, E., Choi, S. H., Tanzi, R. E., … Wrann, C. D. Exercise hormone irisin is a critical regulator of cognitive function, Nature Metabolism, August 20, 2021, Read More

Mondal, P., Bai, P., Gomm, A., Bakiasi, G., Lin, C. J., Wang, Y., Choi, S. H., Tanzi, R. E., Wang, C., & Zhang, C. Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer’s Disease Neuropathology, Advanced Science, November 21, 2023, Read More

Bai, P., Mondal, P., Bagdasarian, F. A., Rani, N., Liu, Y., Gomm, A., Tocci, D. R., Choi, S. H., Wey, H. Y., Tanzi, R. E., Zhang, C., & Wang, C. Development of a potential PET probe for HDAC6 imaging in Alzheimer’s disease, Acta Pharmaceutica Sinica B, May 20, 2022, Read More

Zhang, S., Bai, P., Lei, D., Liang, Y., Zhen, S., Bakiasi, G., Pang, H., Choi, S. H., Wang, C., Tanzi, R. E., & Zhang, C. Degradation and inhibition of epigenetic regulatory protein BRD4 exacerbate Alzheimer’s disease-related neuropathology in cell models, Journal of Biological Chemistry, March 3, 2022, Read More

Liang, Y., Raven, F., Ward, J. F., Zhen, S., Zhang, S., Sun, H., Miller, S. J., Choi, S. H., Tanzi, R. E., & Zhang, C. Upregulation of Alzheimer’s Disease Amyloid-beta Protein Precursor in Astrocytes Both in vitro and in vivo, Journal of Alzheimer's Disease, August 4, 2020, Read More

Choi, S. H., & Tanzi, R. E. Adult neurogenesis in Alzheimer’s disease, Hippocampus, February 7, 2023, Read More

Choi, S. H., Kim, Y. H., Hebisch, M., Sliwinski, C., Lee, S., D'Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., Klee, J. B., Zhang, C., Wainger, B. J., Peitz, M., Kovacs, D. M., Woolf, C. J., Wagner, S. L., Tanzi, R. E., & Kim, D. Y. A Three-dimensional human neural cell culture model of Alzheimer’s disease, Nature, October 12, 2014, Read More

Kim, Y. H., Choi, S. H., D'Avanzo, C., Hebisch, M., Sliwinski, C., Bylykbashi, E., Washicosky, K. J., Klee, J. B., Brüstle, O., Tanzi, R. E., & Kim, D. Y. A 3D human neural cell culture system for modeling Alzheimer’s disease, Nature Protocols, July 1, 2015, Read More

Raven, F., Ward, J. F., Zoltowska, K. M., Wan, Y., Bylykbashi, E., Miller, S. J., Shen, X., Choi, S. H., Rynearson, K. D., Berezovska, O., Wagner, S. L., Tanzi, R. E., & Zhang, C. Soluble Gamma-secretase Modulators Attenuate Alzheimer’s beta amyloid pathology and induce conformational changes in presenili 1, eBioMedicine, September 4, 2017, Read More

Salta, E., Lazarov, O., Fitzsimons, C. P., Tanzi, R., Lucassen, P. J., & Choi, S. H. Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance, Cell Stem Cell, February 2, 2023, Read More

Griciuc, A., Patel, S., Federico, A. N., Choi, S. H., Innes, B. J., Oram, M. K., Cereghetti, G., McGinty, D., Anselmo, A., Sadreyev, R. I., Hickman, S. E., El Khoury, J., Colonna, M., & Tanzi, R. E. TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease, Neuron, July 10, 2019, Read More

Shin, Y., Choi, S. H., Kim, E., Bylykbashi, E., Kim, J. A., Chung, S., Kim, D. Y., Kamm, R. D., & Tanzi, R. E. Blood Brain Barrier Dysfunction in a 3D in vitro model of Alzheimer’s Disease, Advanced Science, August 12, 2019, Read More

Ko, E. C., Spitz, S., Pramotton, F. M., Barr, O. M., Xu, C., Pavlou, G., Zhang, S., Tsai, A., Maaser-Hecker, A., Jorfi, M., Choi, S. H., Tanzi, R. E., & Kamm, R. D. Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model, Frontiers in Bioengineering and Biotechnology, October 9, 2023, Read More

Liang, Y., Lee, D. Y. W., Zhen, S., Sun, H., Zhu, B., Liu, J., Lei, D., Lin, C. J., Zhang, S., Jacques, N. A., Quinti, L., Ran, C., Wang, C., Griciuc, A., Choi, S. H., Dai, R. H., Efferth, T., Tanzi, R. E., & Zhang, C. Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer’s disease, Phytomedicine, May 13, 2022, Read More

Kim, E., Kim, H., Jedrychowski, M. P., Bakiasi, G., Park, J., Kruskop, J., Choi, Y., Kwak, S. S., Quinti, L., Kim, D. Y., Wrann, C. D., Spiegelman, B. M., Tanzi, R. E., & Choi, S. H. Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling, Neuron, September 8, 2023, Read More

Suh, J., Choi, S. H., Romano, D. M., Gannon, M. A., Lesinski, A. N., Kim, D. Y., & Tanzi, R. E. ADAM10 Missense Mutations Potentiate beta-amyloid accumulation by impairing pro-domain chaperone function, Neuron, September 19, 2013, Read More

D'Avanzo, C., Aronson, J., Kim, Y. H., Choi, S. H., Tanzi, R. E., & Kim, D. Y. Alzheimer’s in 3D culture: Challenges and Perspectives, BioEssays, October 1, 2015, Read More

Kumar, D. K., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., & Moir, R. D. Amyloid-beta peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease, Science Translational Medicine, May 25, 2016, Read More

McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., Mindur, J. E., Chan, C. T., He, S., Janssen, H., Wong, L. P., Downey, J., Singh, S., Anzai, A., Kahles, F., Jorfi, M., Feruglio, P.F., Sadreyev, R. I., Weissleder, R., Kleinstiver, B. P., Nahrendorf, M., Tanzi, R. E., & Swirski, F. K. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature, July 14, 2021, Read More

Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta, Neuron, May 22, 2013, Read More