Se Hoon Choi, Ph.D.

Dr. Choi’s interest in Alzheimer’s disease (AD) began when he was a master’s degree student at Seoul National University College of Medicine. He studied toxic proteins causing AD, and developed anti-AD agents to ameliorate the symptoms of the disease. During his Ph.D. study at the University of Chicago, Dr. Choi expanded his interest to researching adult neurogenesis in AD and genes causing familial cases of AD.

He currently is working as an instructor at Massachusetts General Hospital and Harvard Medical School. The goal of his current CAF-funded research is to investigate the role of the blood-brain barrier in AD pathogenesis using a 3D microfluidic platform.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Rudy Tanzi, Se Hoon Choi Exercise and Improved Cognition, Science , September 6, 2018, Read More

Carla D'Avanzo, Jenna Aronson, Young Hye Kim, Se Hoon Choi, Rudolph E. Tanzi and Doo Yeon Kim Alzheimer’s in 3D culture: Challenges and perspectives, BioEssays, 37(10), October 2015, 1139–1148, Read More

Jaehong Suh, Se Hoon Choi, Donna M. Romano, Moira A. Gannon, Andrea N. Lesinski, Doo Yeon Kim, Rudolph E. Tanzi ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function, Neuron, 80(2), Oct 16, 2013, 385–401, Read More

Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling, The Journal of Neuroscience, 30(20), May 19, 2010, 6903-6915, Read More

Choi SH, Li Y, Parada LF, Sisodia SS Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF, Mol Neurodegener, 4, Dec 21, 2009, 52, Read More

Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides, Angewandte Chemi International Edition, Volume 48 Issue 8, February 9, 2009, 1487–1489, Read More

Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation, Neuron, Volume 59, Issue 4, August 28, 2008, 568-580, Read More

Choi SH, Leight SN, Lee VM-Y, Li T, Wong PC, Johson JA, Saraiva MJ, Sisodia SS Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin), J Neurosci, (26), 2007, 7006-7010, Read More