These projects were made possible from Cure Alzheimer's Fund support.
|Understanding the Role of Natural Amyloid Beta-Specific B Cell Responses in Alzheimer’s Disease Progression||
|Two Genes Appear to Act as On/Off Switches for Neuroinflammation and Alzheimer’s Disease||2019|
|TREM2: Role in Modulating Amyloid Beta and Tau-Related Pathologies and Neurodegeneration||
|The Biological Impact of TREM Locus Mutations in Alzheimer’s Disease||
|The Role of TREML2 in Alzheimer’s Disease||
These published papers resulted from Cure Alzheimer’s Fund support.
Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise Anderson, Marco Colonna, David M. Holtzman TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy, Proceedings of the National Academy of Sciences of the United States of America, 114(43), 24 Oct 2017, 11524–11529, Read More
Tyler K. Ulland, Wilbur M. Song, 7, Stanley Ching-Cheng Huang, Jason D. Ulrich, Alexey Sergushichev, Wandy L. Beatty, Alexander A. Loboda, Yingyue Zhou, Nigel J. Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W. Virgin, Emil R. Unanue, Yaming Wang, Maxim N. Artyomov, David M. Holtzman, Marco Colonna TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease, Cell, 170(4), 10 Aug 2017, 649–663, Read More
Jason D. Ulrich, Tyler K. Ulland, Marco Colonna, and David M. Holtzman Elucidating the Role of TREM2 in Alzheimer’s Disease, Neuron, 94, 19 Apr 2017, 237-248, Read More, Download Paper
Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph E. Tanzi, Marco Colonna Alzheimer’s disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia, 13(4), Apr 2017, 381–387, Read More