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Srdjan D. Antic, M.D.

Associate Professor of Neuroscience, University of Connecticut Health Center

Dr. Antic graduated from the School of Medicine Belgrade University, Serbia, and worked at Yale University with Dejan Zecevic and then with Patricia Goldman-Rakic before receiving his first NIH grant in 2001. In 2004, Dr. Antic  joined the Department of Neuroscience, University of Connecticut Health, Farmington, CT, where he currently an Associate Professor. Dr. Antic is interested in dendritic excitability, synaptic integration, and how these two are affected by neuromodulators such as dopamine. He is working on the development of the voltage imaging methods with voltage-sensitive dyes and/or genetically-encoded voltage indicators.

https://health.uconn.edu/antic-lab/

 

Related Research:

Alzheimer’s Disease Pathophysiology Alters the Level of Electrical and Chemical Synapse Coupling in the Network of GABAergic PV+ Interneurons Early in Disease Course Srdjan D. Antic Riqiang Yan 2023-01-05 Physiological Method for Early Detection of Synaptic Vulnerability in Alzheimer’s Disease Model Animals Riqiang Yan Srdjan D. Antic 2018-12-17

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Alzheimer’s Disease Pathophysiology Alters the Level of Electrical and Chemical Synapse Coupling in the Network of GABAergic PV+ Interneurons Early in Disease Course 2022, 2023

$460,000
Physiological Method for Early Detection of Synaptic Vulnerability in Alzheimer’s Disease Model Animals 2018-2019

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Antic, S. D., Yan, P., Acker, C. D., Spagnola, O. T., Erol, Z. Y., Baser, O., & Loew, L. M. ElectroFluor Voltage-Sensitive Dyes: Comprehensive Analysis of Wavelength-Dependent Sensitivity and Cross-Channel Bleed-Through, Journal of Biophotonics, March 18, 2025, Read More

Milicevic, K. D., Ivanova, V. O., Brazil, T. N., Varillas, C. A., Zhu, Y. M. D., Andjus, P. R., & Antic, S. D. The Impact of Optical Undersampling on the Ca2+ Signal Resolution in Ca2+ Imaging of Spontaneous Neuronal Activity, Journal of Integrative Neuroscience, January 21, 2025, Read More

Patel, A. A., Zhu, M. H., Yan, R., & Antic, S. D. Ex vivo propagation of synaptically-evoked cortical depolarizations in a mouse model of Alzheimer’s disease at 20 Hz, 40 Hz, or 83 Hz, Scientific Reports, October 8, 2024, Read More

Milicevic, K. D., Ivanova, V. O., Lovic, D. D., Platisa, J., Andjus, P. R., & Antic, S. D. Plateau depolarizations in spontaneously active neurons detected by calcium or voltage imaging, Scientific Reports, October 4, 2024, Read More

Antic, S. D., Baker, B. J., & Canepari, M. Editorial: New Insights on Neuron and Astrocyte Function from Cutting Edge Optical Techniques, Frontiers in Cellular Neuroscience, October 15, 2019, Read More

Jang, J., Zhu, M. H., Jogdand, A. H., & Antic, S. D. Studying Synaptically Evoked Cortical Responses ex vivo With Combination of a Single Neuron Recording (Whole-Cell) and Population Voltage Imaging (Genetically Encoded Voltage Indicator), Frontiers in Neuroscience, October 27, 2021, Read More

Milicevic, K. D., Zhu, M. H., Barbeau, B. L., Baser, O., Erol, Z. Y., Liu, L. X., Lin, M. Z., & Antic, S. D. Imaging of Evoked Cortical Depolarizations Using Either ASAP2s, or chi-VSFP, or Di-4-Anepps, or Autofluorescence Optical Signals, Journal of Integrative Neuroscience, November 6, 2023, Read More

Milosevic, M. M., Jang, J., McKimm, E. J., Zhu, M. H., & Antic, S. D. In Vitro Testing of Voltage Indicators: Archon1, ArcLightD, ASAP1, ASAP2s, ASAP3b, Bongwoori-Pos6, BeRST1, FlicR1 and Chi-VSFP-Butterfly, eNeuro, August 14, 2020, Read More

Zhu, M. H., Jang, J., Milosevic, M. M., & Antic, S. D. Population imaging discrepancies between a genetically-encoded calcium indicator (GECI) versus a genetically-encoded voltage indicator (GEVI), Scientific Reports, March 5, 2021, Read More

Zhu, M. H., Jogdand, A. H., Jang, J., Nagella, S. C., Das, B., Milosevic, M. M., Yan, R., & Antic, S. D. Evoked Cortical Depolarizations Before and After the Amyloid Plaque Accumulation: Voltage Imaging Study, Journal of Alzheimer's Disease, July 4, 2022, Read More

Milicevic, K. D., Barbeau, B. L., Lovic, D. D., Patel, A. A., Ivanova, V. O., & Antic, S. D. Physiological features of parvalbumin-expressing GABAergic interneurons contributing to high-frequency oscillations in the cerebral cortex, Current Research in Neurobiology, December 16, 2023, Read More

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