Dr. Rob Moir
Researcher Dr. Rob Moir, a member of the Cure Alzheimer's Fund Oligomer Collaborative, and researcher at Massachusetts General Hospital in Boston, presented research supported by Cure Alzheimer's Fund in March to the International Conference on Alzheimer's Disease/Parkinson's Disease that points to evidence that the Abeta peptide, acknowledged to be implicated in the cause of AD, may in fact be a "part of our evolutionary ancient innate immune system." The work is a collaboration between Dr. Moir, Dr. Rudy Tanzi, Chair of the Cure Alzheimer's Fund Research Consortium, and infectious disease expert, Dr. James Kirby (Harvard Medical School).
Read the entire article by AlzForum's Gabrielle Strobel >
A paper released on April 1, 2009, in the Journal of Neuroscience corroborates Prana’s strategy to treat Alzheimer’s disease patients.
Says Dr. Charles Glabe, an author of the paper and member of Cure Alzheimer’s Fund Research Consortium, “these results are very exciting news for understanding the mechanism of Alzheimer’s pathogenesis. They help elucidate the fundamental role of metal ions like zinc in causing the formation of Abeta oligomers which damage synapses.”
While this paper did not have Cure Alzheimer’s Fund support, nor has Cure Alzheimer’s Fund supported the work of Prana, an Australian biotech company, the concepts involved have been central to investigations by Cure Alzheimer’s Fund’s Oligomer Collaborative, of which Dr. Glabe has been a part. (See the Oligomer Collaborative on our website. ) Please note that Dr. Rudy Tanzi, Chair of the Cure Alzheimer’s Fund Research Consortium, is a founder of Prana and endorses its pursuit of therapeutic interventions through anti-Abeta oligomer drugs such as Prana’s PBT2.
Independent Study Corroborates Prana's Strategy to Treat Alzheimer's Disease Patients>
The Alzheimer's Study Group was established on July 11, 2007 under the auspices of the Congressional Task Force on Alzheimer’s Disease with the charge of creating a National Alzheimer's Strategic Plan to overcome America’s mounting Alzheimer's crisis.
The National Alzheimer's Strategic Plan was released at a hearing before the U.S. Senate Special Committee on Aging on Wednesday, March 25th at 10:30 a.m. EDT.
The Alzheimer’s Study Group Strategic Plan>
Cure Alzheimer’s Fund recognizes the significant work of the Alzheimer’s Study Group and appreciates the solid framework they developed for a strategic national plan. However, we also believe we must be more aggressive and ambitious in defining a research agenda and timelines for development of effective therapies in our battle against this devastating disease. The last two decades have shown that understanding the causes and genetic risk factors for Alzheimer’s is absolutely critical to determining the disease models on which effective treatments and a potential cure should be based.
Cure Alzheimer’s Fund’s Statement on the Alzheimer’s Study Group’s Strategic Plan>
Terry Moran, ABC news correspondent, shares his personal story of facing Alzheimer’s and getting his DNA tested for the disease. This segment also features Cure Alzheimer’s Fund Research Consortium member Dr. Sam Gandy participating in an upcoming GQ article spotlighting “rock-star” Alzheimer’s scientists photographed with real rock stars including Sheryl Crow, Will I Am and members of Aerosmith. Look for the issue of GQ on newsstands May 15th.
Terry Moran's Moment of Truth on Nightline>
Getting to a Cure
Why do we need a National Strategy?
- The cost of care for Alzheimer’s patients will overwhelm Medicare and Medicaid if not checked within the next few years.
- With funding from private and public sources heavily constrained, it is essential to make each research dollar count. There is enough consensus in the AD research community now to posit a direction for further research that will maximize resources and minimize the time to a cure.
The Alzheimer's Study Group Strategic Plan provides a solid framework for a strategic national plan to combat the growing crisis of Alzheimer’s disease. It is clear that all involved in this report worked hard to develop a comprehensive strategy for the treatment and care of the more than 5.2 million Americans already battling Alzheimer’s and the 10 million caregivers across the country grappling with the challenges of caring for a loved one with the disease.
The Alzheimer's Study Group Strategic Plan>
Cure Alzheimer's Fund proposes a National Research Strategy to accelerate progress toward a cure. The proposal builds on our own Research Roadmap, and provides a broader path to intervention by 2020.
We have shared this draft with selected members of Congress and their staffs, and with the staff of the Alzheimer's Study Group , a bipartisan effort co-chaired by Newt Gingrich and former Senator Bob Kerrey, and featuring others including Justice Sandra Day O’Connor, Harold Varmus and our own Henry McCance. It is our goal to work collectively with other funding organizations, the National Institutes of Health and related government agencies to avert the looming crisis of Alzheimer’s. If we can agree on the fundamentals of a national research strategy, we can save millions of lives and billions of dollars within the next decade.
Cure Alzheimer's Fund's National Research Strategy>
Q&A on National Research Strategy>
Dr. Sisodia of the University of Chicago and Dr. Gabe of the University of California at Irvine have been awarded the prestigious distinction of fellow of the American Association for the Advancement of Science (AAAS). Founded in 1848, AAAS is the world’s largest general scientific society and publisher of the journal Science.
Dr. Sisodia, a member of the Cure Alzheimer's Fund Research Consortium, is being recognized “for extraordinary contributions to understanding the function and dysfunction of APP and Presenilin 1 in cellular and animal models of Abeta amyloidosis in Alzheimer’s disease.”
Read more in the University of Chicago Chronicle
Dr. Glabe is also a member of the Cure Alzheimer’ Fund Research Consortium and a Professor of Molecular Biology & Biochemistry School of Biological Sciences at UC Irvine. He was one of 20 UC Irvine science and engineering researchers named as AAAS fellows, the largest class in 2008 of any university or institution in the United States.
Alzheimer's Charity Finds Success in Stuart, FL. A recent TC Palm article features the breakthrough work of the Alzheimer's Genome Project and describes the origin of Cure Alzheimer's Fund.
By BY JAN LINDSEY Correspondent
Wednesday, December 24, 2008
STUART — Philanthropist Phyllis Rappaport, a Stuart resident, knows how to pick 'em. The Rappaports were one of four families to found the Cure Alzheimer's Fund in 2004, primarily to back the work of Rudy Tanzi, a scientist affiliated with Harvard University and Massachusetts General Hospital. This year, Tanzi identified 40 human genes related to Alzheimer's and made Time magazine's list of the Top 10 Medical Breakthroughs of 2008.
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