Gary Landreth, Ph.D.

Headshot photo

Professor of Neurosciences and Neurology
Director, Alzheimer Research Laboratory
Case Western Reserve University, School of Medicine

Director of Graduate Education, Department of Neurosciences

AD projects in Dr. Landreth’s laboratory are directed at understanding how the beta-amyloid peptides are normally cleared from the brain and the roles of inflammation in AD pathogenesis. The lab is also engaged in identification and validation of new therapeutic agents for the treatment of AD.  Dr. Landreth received his B.A. from the University of Kansas, and his Ph.D. from the University of Michigan.

Funded Research

Project Description Researchers Funding
Effect of Bexarotene on Abeta in APP Tg Mice Expressing ApoE3 and ApoE4

The goal of this project is to determine the effects of bexarotene on both Abeta and ApoE metabolism in the presence of human Abeta and human ApoE isoforms (any of two or more functionally similar proteins that have a similar but different amino acid sequence) because it is relevant to potential effects of similar drugs in humans.

Mechanisms of Retinoid X Receptor-Mediated Abeta Clearance in Alzheimers' Disease

The goal of this project is to investigate the mechanisms through which RXRs (retinoid x nuclear receptor) promote amyloid clearance from the brain.