“Inside-Out” Amyloid Hypothesis (2014)

Posted February 15, 2018

The Amyloid Hypothesis argues that increases of the amyloid beta protein in the brain triggers a series of events that lead to the pathology and development of Alzheimer’s disease. Charles Glabe, Ph.D., at University of California Irvine advanced an “alternative amyloid hypothesis” to describe how Alzheimer’s disease progresses. Glabe found evidence that amyloid plaques may actually form on the interior of cells, not the exterior as had been the belief. Glabe’s model may help to explain why plaques cause cell death, and bring us closer to identifying exactly where and how Alzheimer’s disease causes damage to the brain.