Esther Landhuis covers the topic thoroughly in a good article on Alzforum.
“Despite recent setbacks on the clinical front, the hunt for small molecules that can cleanly tweak γ-secretase to slow Alzheimer disease seems to be alive and well” writes Esther Landhuis on Alzforum about new γ-secretase modulators.
Tanzi writes that the GSMs “could be used like statins are used today to prevent heart disease. If there was pre-symptomatic evidence that amyloid levels were too high in a patient’s brain, a GSM might be taken to lower relevant peptide levels and reduce AD risk. You don’t want to knock out these peptides. They have a purpose. You just want to dial them back to safe levels.”
The Alzforum piece explains the details behind this exciting work.
Read the article: New γ-Secretase Modulators Reduce Aβ42, Avoid Notch