The Effect of Chronic Gamma-Secretase Modulation on the Prevention of Traumatic Brain Injury-Provoked and Alzheimer’s Disease-Relevant Biochemical, Pathological and Behavioral Alterations

2019 Clinical manifestations of TBI are complex and are associated with sensory, motor, psychiatric and cognitive impairments stemming from a multifaceted series of biochemical, morphological and structural alterations resulting in axonal accumulation and aggregation of a number of proteins and peptides such as APP, Aβ42, hyperphosphorylated tau (tau-P) and neurofilament light ...

December 24, 2018

Brian P. Head, Steven L. Wagner

A NEW AND IMPROVED PROTOCOL FOR STUDYING TAUOPATHIES

Alzheimer’s disease (AD) is characterized by the presence of amyloid-beta (Aβ) plaques and tau neurofibrillary tangles (NFTs). Despite this knowledge, scientists do not know how these tau tangles develop in the first place. A new study published in Cell Reports by Anthony Fitzpatrick, Ph.D. of Columbia University, and Leonard Petrucelli, Ph.D. of ...

December 7, 2021

Your Alzheimer’s Questions Answered: Q&A with Rudy Tanzi

We collected your questions about Alzheimer’s from our fall symposium and social media and presented them to Dr. Rudy Tanzi, chairman of our Research Consortium. Watch the videos below! Q&A with Dr. Rudy Tanzi: Alzheimer’s & Genetics Video of Q&A with Dr. Rudy Tanzi: Alzheimer's & Genetics Part 1: Alzheimer’s and ...

April 17, 2014

Alzheimer’s Genes in the News: What does it all mean?

Setting the stage The 10th Annual International Conference on Alzheimer’s Disease/Parkinson’s Disease (AD/PD) was held this March in Barcelona with thousands of researchers from 68 countries attending. Chief among the topics of interest was determining risk for the disease from genetics. The useful source for all things Alzheimer’s, The Alzheimer’s Research ...

April 7, 2011

Groundbreaking Alzheimer’s Disease Blood Test Subject of Upcoming Webinar

Cure Alzheimer’s Fund will host Dr. David Holtzman for a live webinar on Thursday, May 27 at 5:30 PM.  Diagnosing Alzheimer’s Disease: A Groundbreaking New Blood Test is free and open to the public. Registration is required. Dr. Holtzman is a co-inventor of a new blood test, PrecivityAD, designed to assist ...

May 20, 2021

A Major Achievement! The Alzheimer’s Genome Project

The Alzheimer’s Genome Project™ (AGP) , funded by Cure Alzheimer’s Fund (CAF), is making great scientific progress. This work is providing new understanding of AD pathology and revealing novel genetic information. The more we know about how the disease works, the better the chances are for identifying therapeutic intervention and ...

December 15, 2010

The New York Times Asks: “Will We Ever Cure Alzheimer’s?”

To mark the 40th anniversary of the Science section of The New York Times, the editors made a list of their 11 most pressing science questions they would like answered in the coming years. Given the scale of Alzheimer’s diagnosis in the United States, it is no surprise that the ...

December 13, 2018

Novel Therapies for Alzheimer’s Disease Based on Early Onset Genes

Supplemental Information for Senate Special Committee on Aging Hearing Introduction Alzheimer’s disease (AD), the most common form of dementia, was first described roughly one hundred years ago in Bavaria by Dr. Alois Alzheimer in his presentation of an early-onset (

August 20, 2009

Rudy Tanzi Joins Francis Collins, Director of the National Institutes of Health, Eric Lander of the Broad Institute and Others to Explore Genetic Testing on NOVA

Last week, Cure Alzheimer’s Fund Research Consortium chairman Rudy Tanzi was featured on NOVA in a segment concerning genetic testing. The special followed several cases of people affected by genetic testing, showing both its benefits and challenges. NOVA only briefly touched on Alzheimer’s disease, but provided a comprehensive explanation of ...

April 4, 2012

Alzheimer’s Disease Genes: How Many Do We Know and What Can We Do With Them?

Rudolph E. Tanzi, Ph.D., Joseph P. and Rose F. Kennedy Professor of Neurology, Harvard Medical School; Director, Genetics and Aging Research Unit, Massachusetts General Hospital   The four known Alzheimer’s genes. Over the past several decades, it has become increasingly clear that inheritance plays a major role in Alzheimer’s disease. The roughly 25,000 ...

July 14, 2011