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A Better Way to Look for Diseases’ Genetic Roots

If you haven’t checked out Nicholas Wade’s piece in today’s New York Times, you should. The prominent science writer has taken on the traditional method of gene hunting, claiming there may be a new, arguably more successful, way to look for diseases’ genetic roots — the very research strategy conducted ...

January 26, 2010

Winston Hide

Win Hide applies systems biology approaches to genomic data to reveal and drug critical disease processes occurring in neurodegeneration. This makes it possible to build and implement systems that allow the discovery and prioritization of key target genes and processes involved in complex diseases like Alzheimer’s. He has been funded ...

August 27, 2017

Winston Hide

Discovery of Chemical Compounds That Induce Degradation of APP Beta-CTF

Alzheimer’s disease (AD) is a neurodegenerative disorder that affects more than 5 million people in the United States. One of the hallmarks of AD is the accumulation of amyloid plaques in the brain of patients. The amyloid plaque is composed of beta amyloid (Abeta) peptide, which originates from an amyloid ...

January 11, 2016

Victor Bustos

Validation and Characterization of Compounds Modulating Neuroinflammation and Amyloid Beta Uptake in Microglial Cells

Growing evidence has implicated a critical role for microglia in mediating Alzheimer’s disease (AD) pathogenesis, making them a promising target for AD therapeutics. Impaired microglial phagocytosis results in accumulation of amyloid beta (Aβ), leading to neuroinflammation, which is the primary driver of neurodegeneration. Through an unbiased high-throughput screen of a ...

October 25, 2023

Ana Griciuc, Luisa Quinti

MYTH BUSTING: WHY COCONUT OIL IS NOT A CURE FOR ALZHEIMER’S DISEASE

Circulating on health blogs and twitter posts are claims that coconut oil is the new secret to longevity, cardiovascular health, luminous skin, and enhanced memory. Claims that coconut oil could be considered a dietary antidote to the onset of Alzheimer’s disease compelled us to weigh in with what has and ...

July 17, 2019

Cerebrovascular Dysfunction in AD: Targeting the Mechanisms of Vascular Activation

Our laboratory has worked for almost 30 years to understand how brain blood vessels may be involved in Alzheimer’s disease (AD). Our work is timely and important, as a large body of evidence indicates that cardiovascular risk factors, i.e., conditions that affect blood vessel (vascular) function, increase one’s risk for ...

August 9, 2018

Paula Grammas

Application of Machine Learning Methods in Alzheimer’s Disease Clinical Trials

2022 Alzheimer’s disease (AD) is the leading cause of dementia in older adults. However, the majority of clinical trials aiming to modify the disease process have failed over the last two decades. This is due, in part, to variation among people with AD in both their clinical features and biological underpinnings. ...

February 18, 2020

Ali Ezzati, Richard Lipton