A brief summary of important potential treatments and CAF’s related research. There has been a lot of attention over the last several years about vaccines and Alzheimer’s disease (AD). The buildup of a protein in the brain, that our body normally produces, called “amyloid-beta” plays an important role in AD. ...
August 20, 2009
The microglial regulator CD33 controls brain amyloid-beta clearance in Alzheimer’s disease. We previously performed an unbiased high-throughput screen of FDA-approved medications and CD33-specific antibodies in microglia to identify effective CD33 inhibitors. We found medications that modulated amyloid-beta clearance and microglial activation state. We also found CD33-specific antibodies that dramatically reduced ...
August 9, 2018
Throughout a single lifetime, the brain undergoes many changes. In early development, brain circuits are connected and pruned; in adolescence circuits mature and, in midlife, the menopause transition (MT) impacts a host of brain functions—from energy metabolism to synaptogenesis. Despite the clear link between MT and brain function, very little ...
December 7, 2021
December 16, 2012
January 30, 2024
January 30, 2024
November 25, 2020
This proposal will test whether age-dependent atrophy and loss of barrier function of the recently discovered meningeal membrane named subarachnoid lymphatic-like membrane (SLYM) contributes to recirculation of cerebrospinal fluid and amyloid beta accumulation.
May 2, 2024
October 1, 2018
January 30, 2024
