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Dianne Domer

Dianne Domer, 85, passed away with family by her side on April 26, 2024 in Colorado Springs, CO. A daughter of the late Mabel and Albert Dick, she was born in Fremont, Ohio on September 24, 1938. After high school, she graduated from Bowling Green State University where she was ...

May 2, 2024

Microglial Heterogeneity and Transcriptional State Changes in Alzheimer’s Disease

Alzheimer’s disease is the health challenge of our generation. The majority of AD cases are late onset and result from the interaction of multiple genetic and nongenetic risk factors, of which the most important is aging. Genetic studies implicate the brain’s resident immune cells, microglia, in the pathogenesis of late-onset ...

June 19, 2018

Beth Stevens

Move For Minds to Benefit Alzheimer’s Research – June 3, 2018

Maria Shriver and The Women’s Alzheimer’s Movement invite you to join Move for Minds 2018 in Boston! On June 3, we’ll gather at the Equinox Sports Club in Boston for a day of exercise, inspiration and information as we learn about how to keep our brains working at their best. THE EVENT Move ...

May 15, 2018

Alfred W. Simpkins

Alfred W. Simpkins, 93, passed away on Monday, September 26, 2016 at the Eddy Village Green, Cohoes, NY. Born in Cairo, NY, he was the only child of Floyd and Olive Simpkins.   After graduating from Cairo High School and attending Syracuse University, he served in the Army from 1943-1946.  Following the ...

October 6, 2016

The Role of PICALM in Vascular Clearance of Amyloid Beta

PICALM, the gene encoding phosphatidylinositol binding clathrin assembly (picalm) protein, plays a key role in endocytosis, a process which regulates the function of cell receptors and synaptic transmission. PICALM is one of the most highly validated Alzheimer’s disease (AD) risk factors. Its role in AD, however, is unknown. A recent ...

December 5, 2012

Berislav Zlokovic

The R(evolution) of Alzheimer’s in a Dish

In 2014, Drs. Rudy Tanzi and Doo Yeon Kim resolved one of the critical challenges of Alzheimer’s disease research: how to grow human brain cells that exhibit the hallmarks of Alzheimer’s pathology in a form mimicking that of a brain. This new tool allowed for a more thorough testing of ...

October 25, 2018

The Role of Neurexins in Alzheimer’s Disease (Year 2)

Alzheimer’s disease is the most common form of dementia among the elderly. Current studies strongly support the notion that abnormal processing of amyloid beta and accumulation of amyloid beta peptide are the critical events that are associated to the AD pathogenesis. However, the mechanisms of how amyloid beta accumulates at ...

June 19, 2018

Meng Chen, Rudolph Tanzi

miRNAs in AD Pathology

This project will test the hypothesis that microRNAs regulate protein levels of APP and Genome Wide Association Screen (GWAS)-identified levels of APP and GWAS-identified risk genes.

February 11, 2011

Aleister J. Saunders