/* > The goal of this project is to evaluate the pathological significance of a new type of Abeta deposits in the brain (at the onset of Alzheimerās disease) in order to develop a novel mechanism for amyloid pathogenesis to help convince the FDA to approve and support early clinical trials. Although ...
November 11, 2011
This collaborative project will identify and characterize novel curcumin-like derivatives for the treatment and prevention of Alzheimerās disease. The purpose of the study is to develop means of overcoming obstacles to rapid breakdown and creating methodologies for precisely delivering curcumin derivatives to appropriate locations within the brain.
February 12, 2011
2020 Genetics and neuropathology of Alzheimerās disease clearly point to the importance for pathogenesis of decreased gamma-secretase-mediated processing of the amyloid precursor protein with consequent increased levels of long, aggregation-prone amyloid beta peptides. Recent research has provided evidence that the disease develops as a vicious cycle of impaired function of gamma-secretase, ...
January 10, 2019
Founded in 2013 by Jake and Josh Akman in honor of their grandfather, Dr. Richard Hollander, The Dick Hollander Openā¢ is a charity golf tournament that raises money for Alzheimerās research. āA retired pediatrician and an extremely loving man, our grandfather has suffered for more than 15 years from Alzheimerās. ...
April 24, 2013
Four papers published this fall in leading science journals refer to the identification of new genes that confer risk for, or protection against, Alzheimerās disease. Ā Ā The articles: Bertram L and Tanzi RE. Thirty Years of Alzheimerās Disease Genetics: Systematic Meta-analyses Herald a New Era. Nature Reviews Neurosci 2008; 9:768-78. Bertram L, Lange C, ...
August 20, 2009
Weāre Janet Hilts and Susan Hilts Brown, twin sisters. Our dear friend Alexander has been our close buddy since we were in diapers and now has early onset Alzheimer’s. As we help care for him, weāre training in our hills and raising money for the cure at the same time. ...
January 20, 2016
Alzheimerās disease (AD) pathology comprises the accumulation of incorrectly folded proteins accompanied by oxidative stress and sustained inflammation that result in a neurodegenerative disease. This pathological process develops in the brain starting approximately 20 years before the appearance of symptomatic dementia. These years should be regarded as an incubation period ...
February 23, 2023
December 14, 2021
Tau tangles are the most prevalent pathology in neurodegenerative diseases such as Alzheimerās disease (AD) and frontotemporal dementia (FTD), and the tau (MAPT) region is genetically associated with these diseases. Large gaps in our knowledge remain regarding how neurodegenerative disease-linked tau mutations and MAPT variation promote tau aggregation and neurodegeneration. ...
January 6, 2023
Dr. Schadt is Director of theĀ Icahn Institute for Genomics and Multiscale Biology, Chair of the Department of Genetics and Genomics Sciences, and the Jean C. and James W. Crystal Professor of Genomics at the Icahn School of Medicine at Mount Sinai. Dr. Schadt is an expert on the generation and integration ...
August 28, 2016
