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Research Consortium Recap

Every year the Cure Alzheimerā€™s Fund (CAF) Research Consortium members get together with the Board of Directors to discuss their respective research projects, refine their strategy, and leave with a clear mission. This year was no exception. On Feb. 5, 30 individuals gathered in San Diego for a full day of ...

April 21, 2015

Cholesterol and Alzheimer’s: A Big Step Forward

For several years now, researchers have been aware of important links between cholesterol and Alzheimer’s disease. A new study by Dr. Dora Kovacs and her team at Massachusetts General Hospital brings us one step closer to a potential drug that could interrupt the disease process. Previous studies have shown that cholesterol ...

July 29, 2013

Newly Identified Gene Variations Provide Clues About Origins of Alzheimerā€™s

Research uncovering 12 new gene variations connected to the cause of the early-onset familial form of Alzheimerā€™s disease (EO-FAD), which generally strikes before the age of 65, is being published in the journal Molecular Psychiatry. The Cure Alzheimerā€™s Fund-supported research conducted a comprehensive genome-wide screen of over 100 EO-FAD families, identifying ...

June 18, 2013

Modulation of Abeta Deposition by Cell-Specific Mechanisms

The goal of this project is to determine which types of cells and factors in the brain influence excess Abeta deposition in Alzheimerā€™s patients, using animal models of the disease. Alzheimerā€™s disease (AD) is a progressive neurodegenerative disease characterized by impairments in memory and cognition, neuronal loss and deposition of Abeta ...

February 11, 2011

Sangram S. Sisodia

Solanezumab Fails in Trial — But May Still Help with Mild Alzheimer’s

On Friday, August 24, Eli Lilly announced that their beta-amyloid immunotherapy (solanezumab) failed to meet its primary clinical endpoints for Alzheimer’s disease. This disappointment follows the recent failure of another promising beta-amyloid immunotherapy, bapineuzumab from Pfizer/Johnson and Johnson-Jannsen/Elan. Both drugs failed in Phase 3 clinical trials, where they were being ...

August 27, 2012

Help Us Stop Alzheimer’s

Dear Friends, Ā  For many years, Alzheimerā€™s disease research was stuck, and we set out to get it unstuck. Ā  The drug pipeline was coming up dry, and researchers werenā€™t encouraged to think big or bold. Even the most prominent Alzheimerā€™s scientists were spending a third of their time filling out lengthy grant applications. ...

December 20, 2011

VIDEO: TEDMED 2010 Sparks Discussion on AD Treatment and Funding

Cure Alzheimer’s Fund co-founder and venture capitalist Henry McCance and Dr. Rudolph Tanzi discuss the latest research on Alzheimer’s, the hope of discovering a cure by 2020 and the success of using a venture capital funding model to spur on research at TEDMED 2010. Alzheimer’s Reading Room, a leading source of ...

July 7, 2011

Larry King highlights Alzheimerā€™s epidemic on CNN special Sunday, May 1

CNN will be airing the Larry King special ā€œUnthinkable: the Alzheimerā€™s Epidemicā€ on Sunday, May 1 at 8:00 PM in most time zones. King will explore Alzheimerā€™s disease, the people it affects, its impact on their families, the latest in treatment, and why it is critical to find a cure ...

April 25, 2011

Another Victim of Alzheimer’s

We note with great sorrow the passing of Sargent Shriver.Ā  Another victim of Alzheimerā€™s disease. Shriver and his family have made tremendous contributions to American society through the Peace Corps, Special Olympics and so many other positive initiatives to affect the lives of people left out, left behind or disenfranchised in ...

January 19, 2011