Cure Alzheimer's Fund Cure Alzheimer's Fund

David M. Gate, Ph.D.

Assistant Professor of Neurology, Northwestern University Feinberg School of Medicine

Dr. Gate received his graduate degree in Integrative Biology of Disease from the University of Southern California in 2015. He completed postdoctoral training in the Wyss-Coray lab at Stanford University in 2020. He is currently a faculty member in Northwestern Neurology, where he studies the role of adaptive immunity in neurodegeneration. His work focuses on the interplay between T cells and neurodegenerative disease antigens. For this work, he has received an NIH/NINDS K99/R00 grant, Alzheimer’s Association Young Investigator Award, a Junior Faculty Award from the AD/PD Congress, and was recently awarded the 10X Genomics Early Career Investigator Award.

Twitter: @DGateLab

 

Related Research:

Single Nucleus RNA Sequencing Analysis of ACE1 R1284Q Knock-in Mice Robert Vassar David M. Gate Leah Cuddy 2022-05-03 T Cell Epigenetics in Alzheimer’s Disease David M. Gate 2022-02-14

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Single Nucleus RNA Sequencing Analysis of ACE1 R1284Q Knock-in Mice 2022

$246,804
T Cell Epigenetics in Alzheimer’s Disease 2021, 2023

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Adameyko, I., Bakken, T., Bhaduri, A., Chhatbar, C., Filbin, M. G., Gate, D., … Liddelow, S. A., Nowakowski, T. J. Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system, Nature Neuroscience, December 3, 2024, Read More

Jeon, S., Salvo, M. A., Alia, A. O., Popovic, J., Zagardo, M., Chandra, S., Nassan, M., Gate, D., Vassar, R., & Cuddy, L. K. Neuronal ACE1 knockout disrupts the hippocampal renin angiotensin system leading to memory impairment and vascular loss in normal aging, Neurology of Disease, November 7, 2024, Read More

10. Kloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., … Gate, D., … , Iadecola, C., Johnson, L. A., Kanekiyo, T., … Lamb, B.T., … Marcora, E., … Morganti, J. M., … Ramachandran, K. V., … Tsai, L. H., … Ulrich, J. D., van der Kant, R., … Wellington, C. L., … Zhao, N., Bu, G., Goate, A. M., Holtzman, D. M. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference, Alzheimer's & Dementia, July 19, 2024, Read More

Ramakrishnan, A., Piehl, N., Simonton, B., Parikh, M., Zhang, Z., Teregulova, V., van Olst, L., & Gate, D. Epigenetic dysregulation in Alzheimer’s disease peripheral immunity, Neuron, January 31, 2024, Read More

Gate D. New Perspectives on Immune Involvement in Parkinson’s Disease Pathogenesis, Journal of Parkinson's disease, September 27, 2022, Read More

Piehl, N., van Olst, L., Ramakrishnan, A., Teregulova, V., Simonton, B., Zhang, Z., Tapp, E., Channappa, D., Oh, H., Losada, P. M., Rutledge, J., Trelle, A. N., Mormino, E. C., Elahi, F., Galasko, D. R., Henderson, V. W., Wagner, A. D., Wyss-Coray, T., & Gate, D. Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment, Cell, December 13, 2022, Read More

Whitson, H. E., Colton, C., El Khoury, J., Gate, D., Goate, A., Heneka, M. T., Kaddurah-Daouk, R., Klein, R. S., Shinohara, M. L., Sisodia, S., Spudich, S. S., Stevens, B., Tanzi, R., Ting, J. P., Garden, G., & Symposium Planning Committee members. Infection and inflammation: New perspectives on Alzheimer’s disease, Brain, Behavior, & Immunity - Health, April 22, 2022, Read More

Back to Our Researchers