Derek H. Oakley M.D., Ph.D.

Instructor in Pathology, Massachusetts General Hospital, Harvard Medical School


Derek H. Oakley M.D., Ph.D. is a neuropathologist and stem cell biologist who specializes in the diagnosis and modeling of neurodegenerative disease. He completed his M.D. and Ph.D. training at Columbia University where he helped develop some of the first induced pluripotent stem cell (iPSC)-models of amyotrophic lateral sclerosis (ALS).  He then completed a residency in Anatomic Pathology and a fellowship in Neuropathology at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS). He is currently an Instructor in Pathology at MGH/HMS where he serves as an attending on the neuropathology and autopsy services and conducts research on Alzheimer’s disease and related dementias using patient-derived iPSCs. His current work focuses on understanding the relationship between phenotypes of disease in iPSC-derived neurons and matched donated brain tissues as well as tau aggregation and toxicity in human iPSC-neurons.  He is also the Director of Neuropathology for the Harvard Brain Tissue Resource Center (HBTRC) at McLean hospital, a staff neuropathologist for the Massachusetts Alzheimer’s Disease Research Center (MADRC), and the network neuropathologist for the Autism Brain Network.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.