Cure Alzheimer's Fund Cure Alzheimer's Fund

Evandro F. Fang, Ph.D.

Associate Professor, Molecular Gerontology, University of Oslo (UiO), Norway

Evandro F. Fang is an Associate Professor of Molecular Gerontology at the University of Oslo (UiO), Norway, and his group are working on the molecular mechanisms of human ageing and age-predisposed neurodegeneration (https://evandrofanglab.com/). More specifically, the Fang laboratory is focusing on the molecular mechanisms behind how cells clear their damaged and aged mitochondria, a process termed “mitophagy”, as well as the roles of the NAD+-mitophagy/autophagy axis in healthy ageing and AD inhibition. NAD+ is a fundamental molecule in life and health and decreases in ageing and AD. Dr Fang is fascinated with and actively engaged in moving his laboratory findings to translational applications and is involved in 5+ NAD+-based clinical trials, with the overarching goal of establishing novel and safe biological approaches to promote longer and healthier human lives.

After finishing his Ph.D. at the Chinese Universtiy of Hong Kong, he had a 6-year postdoc training with Prof. Vilhelm Bohr on molecular gerontology at the National Institute on Ageing, Baltimore. He opened his lab in Oslo in the fall of 2017. He has published over 100 papers in international peer-reviewed journals including papers in Cell, Cell Metabolism, Nature Reviews MCB, Nature Neuroscience, Nature Ageing, and Nature Biomedical Engineering. He has received several awards including the Butler-Williams Scholar on Aging 2016 by NIA (USA) and the ‘Scientific Award to Young Scientist in the Natural Sciences for 2020 by The Royal Norwegian Society of Sciences and Letters (Norway). He is the founding (co)coordinator of the Norwegian Centre on Healthy Ageing network (NO-Age, www.noage100.com), the Norwegian National anti-Alzheimer’s disease Network (NO-AD, www.noad100.com), and the Hong Kong-Nordic Research Network.

Related Research:

Turning Up Mitophagy to Blunt Alzheimer’s Tau Pathologies Evandro F. Fang 2022-11-21

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Turning Up Mitophagy to Blunt Alzheimer’s Tau Pathologies 2022

$201,250

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Wang, H. L., & Fang, E. F. PFASs May Risk Alzheimer’s Disease, The Journals of Gerontology. Series A, February 13, 2024, Read More

Pun, F. W., Leung, G. H. D., Leung, H. W., Rice, J., Schmauck-Medina, T., Lautrup, S., Long, X., Liu, B. H. M., Wong, C. W., Ozerov, I. V., Aliper, A., Ren, F., Rosenberg, A. J., Agrawal, N., Izumchenko, E., Fang, E. F., & Zhavoronkov, A. A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging, Aging Cell, October 27, 2023, Read More

Knapskog, A. B., Aksnes, M., Edwin, T. H., Ueland, P. M., Ulvik, A., Fang, E. F., Eldholm, R. S., Halaas, N. B., Saltvedt, I., Giil, L. M., & Watne, L. O. Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer’s disease, Alzheimer's & Dementia, June 2, 2023, Read More

Fang, E. F., Tavernarakis, N., & Palikaras, K. Editorial: Mitophagy in health and disease, volume II, Frontiers in Cell and Developmental Biology, June 29, 2023, Read More

Dong, Y., Zhuang, X. X., Wang, Y. T., Tan, J., Feng, D., Li, M., Zhong, Q., Song, Z., Shen, H. M., Fang, E. F., & Lu, J. H. Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms, Pharmacological Research, June 20, 2023, Read More

Wang, H. L., Siow, R., Schmauck-Medina, T., … Fang, E. F. Meeting summary of The NYO3 5th NO-Age/AD meeting and the 1st Norway-UK joint meeting on ageing and dementia: recent progress on the mechanisms and interventional strategies, The Journals of Gerontology. Series A, January 30, 2024, Read More

Hong, Y., Zhang, Z., Yangzom, T., Chen, A., Lundberg, B. C., Fang, E. F., Siller, R., Sullivan, G. J., Zeman, J., Tzoulis, C., Bindoff, L. A., & Liang, K. X. The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers’ Disease, International Journal of Biological Sciences, January 25, 2024, Read More

Lautrup, S., Hou, Y., Fang, E. F., & Bohr, V. A. Roles of NAD+ in Health and Aging, Cold Spring Harbor Perspectives in Medicine, January 2, 2024, Read More

Fu, L., Tian, T., Wang, B., Lu, Z., Bian, J., Zhang, W., Wu, X., Li, X., Siow, R. C., Fang, E. F., He, N., & Zou, H. Global, regional, and national burden of HIV and other sexually transmitted infections in older adults aged 60–89 years from 1990 to 2019: results from the Global Burden of Disease Study 2019, The Lancet. Healthy Longevity, January 1, 2024, Read More

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