Cure Alzheimer's Fund Cure Alzheimer's Fund

George S. Bloom, Ph.D.

Professor of Biology, Cell Biology, and Neuroscience, University of Virginia

Dr. Bloom obtained his Bachelor of Arts degree from the University of Pennsylvania in 1973 and his Ph.D. from the University of Pennsylvania in 1979. He then completed two postdoctoral fellowships: from 1979–1980 at the University of North Carolina’s Cancer Research Center, and from 1980–1984 at the Worcester Foundation for Experimental Biology, where his longstanding interest in neuronal cell biology was initiated in the laboratory of Dr. Richard Vallee. After finishing his postdoctoral training in 1984, Dr. Bloom joined the faculty of the Department of Cell Biology at the University of Texas Southwestern Medical Center, where he remained until his move to the University of Virginia in 2000.

Visit the Bloom Lab website to learn more.

Related Research:

Toxic Effects of Extracellular Tau Oligomers on Neurons George S. Bloom 2022-12-22 Adult Human iNeurons: A Next-Generation Drug Screening Platform for Alzheimer’s Disease George S. Bloom Elizabeth R. Sharlow John S. Lazo 2020-12-21 Targeting Cell Cycle Re-entry Using 3-D Neuron Cultures Elizabeth R. Sharlow George S. Bloom John S. Lazo 2018-08-27 Cell Cycle Re-entry in 3-D Human Neuron Cultures John S. Lazo George S. Bloom 2015-09-28 Structural and Functional Analysis of Novel Abeta and Tau Oligomers Using Conformation-Specific Monoclonal Antibodies George S. Bloom 2011-11-11

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Toxic Effects of Extracellular Tau Oligomers on Neurons 2022, 2023

$390,952
Adult Human iNeurons: A Next-Generation Drug Screening Platform for Alzheimer’s Disease 2020, 2021

$444,498
Targeting Cell Cycle Re-entry Using 3-D Neuron Cultures 2017 and 2018

$420,681
Cell Cycle Re-entry in 3-D Human Neuron Cultures 2015, 2016

$200,000
Structural and Functional Analysis of Novel Abeta and Tau Oligomers Using Conformation-Specific Monoclonal Antibodies 2011

$100,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Norambuena, A., Sagar, V. K., Wang, Z., Raut, P., Feng, Z., Wallrabe, H., Pardo, E., Kim, T., Alam, S. R., Hu, S., Periasamy, A., & Bloom, G. S. Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock-in mouse model of Alzheimer’s disease, Alzheimer's & Dementia, August 22, 2024, Read More

Porterfield, V., Khan, S. S., Foff, E. P., Koseoglu, M. M., Blanco, I. K., Jayaraman, S., Lien, E., McConnell, M. J., Bloom, G. S., Lazo, J. S., & Sharlow, E. R. A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype, Neurobiology of Aging, February 19, 2020, Read More

Bloom, G. S., Lazo, J. S., & Norambuena, A. Reduced brain insulin signaling: A seminal process in Alzheimer’s disease pathogenesis, Neuropharmacology, September 27, 2017, Read More

Nussbaum, J. M., Schilling, S., Cynis, H., Silva, A., Swanson, E., Wangsanut, T., Tayler, K., Wiltgen, B., Hatami, A., Rönicke, R., Reymann, K., Hutter-Paier, B., Alexandru, A., Jagla, W., Graubner, S., Glabe, C. G., Demuth, H. U., & Bloom, G. S. Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta, Nature, May 2, 2012, Read More

Wu, L., Wang, Z., Lad, S., Gilyazova, N., Dougharty, D. T., Marcus, M., Henderson, F., Ray, W. K., Siedlak, S., Li, J., Helm, R. F., Zhu, X., Bloom, G. S., Wang, S. J., Zou, W. Q., & Xu, B. Selective Detection of Misfolded Tau From Postmortem Alzheimer’s Disease Brains, Frontiers in Aging Neuroscience, July 20, 2022, Read More

Nussbaum, J. M., Seward, M. E., & Bloom, G. S. Alzheimer disease A tale of two prions, Prion, September 10, 2012, Read More

Norambuena, A., Sun, X., Wallrabe, H., Cao, R., Sun, N., Pardo, E., Shivange, N., Wang, D. B., Post, L. A., Ferris, H. A., Hu, S., Periasamy, A., & Bloom, G. S. SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers, Neurobiology of Disease, April 20, 2022, Read More

Khan, S. S., & Bloom, G. S. Tau: the center of a signaling nexus in Alzheimer’s disease, Frontiers in Neuroscience, February 9, 2016, Read More

Bloom, G. S., & Norambuena, A. Alzheimer’s disease as a metabolic disorder, Lipids, August 1, 2018, Read More

Swanson, E., Breckenridge, L., McMahon, L., Som, S., McConnell, I., & Bloom, G. S. Extracellular tau oligomers induce invasion of endogenous tau into the somatodendritic compartment and axonal transport dysfunction, Journal of Alzhiemer's Disease, January 1, 2017, Read More

Rudenko, L. K., Wallrabe, H., Periasamy, A., Siller, K. H., Svindrych, Z., Seward, M. E., Best, M. N., & Bloom, G. S. Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-beta Oligomers, Journal of Alzheimer's Disease, October 15, 2019, Read More

Best, M. N., Lim, Y., Ferenc, N. N., Kim, N., Min, L., Wang, D. B., Sharifi, K., Wasserman, A. E., McTavish, S. A., Siller, K. H., Jones, M. K., Jenkins, P. M., Mandell, J. W., & Bloom, G. S. Extracellular Tau Oligomers Damage the Axon Initial Segment, Journal of Alzheimer's Disease, May 9, 2023, Read More

Kuwar, R., Rolfe, A., Di, L., Blevins, H., Xu, Y., Sun, X., Bloom, G. S., Zhang, S., & Sun, D. A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer’s Disease Transgenic Mice, Journal of Alzheimer's Disease, January 1, 2021, Read More

Bloom, G. S. Amyloid-beta and Tau: the trigger and bullet in Alzheimer’s disease pathogenesis, JAMA Neurology, April 1, 2014, Read More

Bloom, G. S., & Baas, P. W. A half-century of tau, Cytoskeleton, August 28, 2023, Read More

Bloom, G. S., & Norambuena, A. Dysregulation of mTOR by tau in Alzheimer’s disease, Cytoskeleton, August 28, 2023, Read More

Kodis, E. J., Choi, S., Swanson, E., Ferreira, G., & Bloom, G. S. N-methyl-D-aspartate receptor-mediated calciuym influx connects amyloid-beta oligomers to ectopic neuronal cell cycle re-entry in Alzheimer’s Disease, Alzheimer's & Dementia, October 1, 2018, Read More

Rajbanshi, B., Guruacharya, A., Mandell, J. W., & Bloom, G. S. mTOR and neuronal cell cycle re-entry: how impaired brain insulin signaling promotes Alzheimer’s disease, Alzheimer's & Dementia, February 1, 2017, Read More

Rajbanshi, B., Guruacharya, A., M|ell, J. W., & Bloom, G. S. Localization, induction, and cellular effects of tau phosphorylated at threonine 217, Alzheimer's & Dementia, January 12, 2023, Read More

Khan, S. S., LaCroix, M., Boyle, G., Sherman, M. A., Brown, J. L., Amar, F., Aldaco, J., Lee, M. K., Bloom, G. S., & Lesné, S. E. Bidirectional modulation of Alzhiemer’s phenotype by alpha-synuclein in mice and primary neurons, Acta Neuropathologica, October 1, 2018, Read More

Sun, X., Eastman, G., Shi, Y., Saibaba, S., Oliveira, A. K., Lukens, J. R., Norambuena, A., Thompson, J. A., Purdy, M. D., Dryden, K., Pardo, E., Mandell, J. W., & Bloom, G. S. Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers, Alzheimer's & Dementia, December 9, 2023, Read More

Sharlow, E. R., Leimgruber, S., Lira, A., McConnell, M. J., Norambuena, A., Bloom, G. S., Epperly, M. W., Greenberger, J. S., & Lazo, J. S. A Small molecule screen exposes mTOR signaling pathway involvement in radiation-induced apoptosis, ACS Chemical Biology, May 14, 2016, Read More

Eastman, G., Sharlow, E. R., Lazo, J. S., Bloom, G. S., & Sotelo-Silveira, J. R. Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer’s Disease Model Mice, Journal of Alzheimer's Disease, March 8, 2022, Read More

Sharlow, E. R., Llaneza, D. C., Grever, W. E., Mingledorff, G. A., Mendelson, A. J., Bloom, G. S., & Lazo, J. S. High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons, SLAS Discovery, October 20, 2022, Read More

Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer, Journal of Alzheimer's Disease, January 8, 2019, Read More

Koseoglu, M. M., Norambuena, A., Sharlow, E. R., Lazo, J. S., & Bloom, G. S. Aberrant neuronal cell-cycle re-entry: the pathological confluence fo Alzheimer’s disease and brain insulin resistance, and its relation to cancer., Journal of Alzheimer's Disease, January 8, 2019, Read More

Sharlow, E. R., Llaneza, D. C., Tewari, B. P., Mingledorff, G. A., Mendelson, A. J., Sontheimer, H., Bloom, G. S., & Lazo, J. S. Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations, FEBS Journal, July 10, 2023, Read More

Sharlow, E. R., Koseoglu, M. M., Bloom, G. S., & Lazo, J. S. The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons, Assay and Drug Development Technologies, February 14, 2020, Read More

Norambuena, A., Wallrabe, H., Cao, R., Wang, D. B., Silva, A., Svindrych, Z., Periasamy, A., Hu, S., Tanzi, R. E., Kim, D. Y., & Bloom, G. S. A novel lysosome-to-micochondria signaling pathway disrupted by amyloid-beta oligomes, The EMBO Journal, October 22, 2018, Read More

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