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Joel Blanchard, Ph.D.

Associate Professor of Neuroscience at the Icahn School of Medicine at Mt. Sinai

Joel Blanchard is an Associate Professor of Neuroscience at the Icahn School of Medicine at Mt. Sinai in New York City. He is also an investigator in the Ronald Loeb Alzheimer’s Disease Center and the Black Family Stem Cell Institute. His research aims to understand how genetics, diet, and traumatic injury influence the susceptibility of the human brain to neurodegenerative diseases such as Alzheimer’s Disease. His multidisciplinary research combines engineering, stem cell biology, and neuroscience to create new technology and approaches for investigating and therapeutically targeting the human brain. Dr. Blanchard completed his post-doctoral training at MIT, a Ph.D. at Scripps Research Institute in California, and a master’s at Harvard University.

To learn more, visit the Blanchard Lab Website.

Follow Dr. Blanchard on X (formerly known as Twitter) @JoelWBlanchard1.

Related Research:

Investigating Lysosomal Mechanisms of Risk and Resilience in Alzheimer’s Disease Joel Blanchard 2023-12-09 Establishing the Molecular and Cellular Mechanisms and Biomarkers of APOE4-Mediated Susceptibility to Tau-Related Cognitive Impairments Joel Blanchard 2022-02-10

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Investigating Lysosomal Mechanisms of Risk and Resilience in Alzheimer’s Disease 2023, 2024

$402,500
Establishing the Molecular and Cellular Mechanisms and Biomarkers of APOE4-Mediated Susceptibility to Tau-Related Cognitive Impairments 2021, 2022

$345,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Goldman, C., Kareva, T., Sarrafha, L., Schuldt, B. R., Sahasrabudhe, A., Ahfeldt, T., & Blanchard, J. W. Genetically encoded and modular subcellular organelle probes reveal dysfunction in lysosomes and mitochondria driven by PRKN knockout, iScience, July 3, 2025, Read More

Goldman, C., Suhy, N., Schwarz, J. E., Sartori, E. R., Rooklin, R. B., Schuldt, B. R., Mesentier-Louro, L. A., & Blanchard, J. W. Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease, Journal of Visualized Experiments, October 20, 2023, Read More

Mesentier-Louro, L. A., Suhy, N., Broekaart, D., Bula, M., Pereira, A. C., & Blanchard, J. W. Modeling the Blood-Brain Barrier Using Human-Induced Pluripotent Stem Cells, Methods in Molecular Biology, June 11, 2023, Read More

Blanchard, J. W., Akay, L. A., Davila-Velderrain, J., von Maydell, D., … Kellis, M., Tsai, L. H. APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes, Nature, November 16, 2022, Read More

Li, H., Przybyla, L., & Blanchard, J. W. Editorial: Understanding human biology with iPSC derived cell types in the era of CRISPR technology, Fronetiers in Cell and Developmental Biology, December 22, 2023, Read More

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