These projects were made possible from Cure Alzheimer's Fund support.
These published papers resulted from Cure Alzheimer’s Fund support.
Boskovic, P., Gao, W., & Kipnis, J. Will cellular immunotherapies end neurodegenerative diseases?, Trends in Immunology, April 9, 2024, Read More
Smyth, L. C. D., Xu, D., Okar, S. V., Dykstra, T., Rustenhoven, J., Papadopoulos, Z., … Kipnis, J. Identification of direct connections between the dura and the brain, Nature, February 7, 2024, Read More
Rustenhoven, J., Pavlou, G., Storck, S. E., Dykstra, T., Du, S., Wan, Z., Quintero, D., Scallan, J. P., Smirnov, I., Kamm, R. D., & Kipnis, J. Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage, Journal of Experimental Medicine, April 7, 2023, Read More
Drieu, A., Du, S., Storck, S. E., Rustenhoven, J., Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., Harari, O., Karch, C. M., Bateman, R. J., Perrin, R., Farlow, M., Chhatwal, J., Dominantly Inherited Alzheimer Network, Hu, S., Randolph, G. J., Smirnov, I., … Kipnis, J. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid, Nature, November 9, 2022, Read More
Louveau, A., Da Mesquita, S., & Kipnis, J. Lymphatics in Neurological Disorders: a neuro-lympho-vascular component of multiple sclerosis and Alzheimer’s disease?, Neuron, September 7, 2016, Read More
Ozturk, B., Koundal, S., Al Bizri, E., Chen, X., Gursky, Z. H., Dai, F., Lim, A. S., Heerdt, P., Kipnis, J., Tannenbaum, A., Lee, H., & Benveniste, H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport, JCI Insight, May 9, 2023, Read More
Mazzitelli, J. A., Pulous, F. E., Smyth, L. C. D., Kaya, Z., Rustenhoven, J., Moskowitz, M. A., Kipnis, J., & Nahrendorf, M. Skull bone marrow channels as immune gateways to the central nervous system, Nature Neuroscience, November 23, 2023, Read More
Da Mesquita, S., Herz, J., Wall, M., Dykstra, T., de Lima, K. A., Norris, G. T., Dabhi, N., Kennedy, T., Baker, W., & Kipnis, J. Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology, Scientific Advances, May 21, 2021, Read More
Da Mesquita, S., Fu, Z., & Kipnis, J. The meningeal lymphatic system: a new player in neurophysiology, Neuron, October 24, 2018, Read More
Mazzitelli, J. A., Smyth, L. C. D., Cross, K. A., Dykstra, T., Sun, J., Du, S., Mamuladze, T., Smirnov, I., Rustenhoven, J., & Kipnis, J. Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels, Nature Neuroscience, March 17, 2022, Read More
Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., Viar, K. E., Powell, R. D., Baker, W., Dabhi, N., Bai, R., Cao, R., Hu, S., Rich, S. S., Munson, J. M., Lopes, M. B., … Kipnis, J. Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease, Nature, July 25, 2018, Read More
Norris, G. T., & Kipnis, J. Immune Cells and CNS physiology: microglia and beyond, Journal of Experimental Medicine, November 30, 2018, Read More
Rustenhoven, J., Tanumihardja, C., & Kipnis, J. Cerebrovascular Anomalies: Perspectives From Immunology and Cerebrospinal Fluid Flow, Circulation Research, June 25, 2021, Read More
Rustenhoven, J., Drieu, A., Mamuladze, T., de Lima, K. A., Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., Lemieux, M., Da Mesquita, S., Cugurra, A., Fitzpatrick, J., Sviben, S., Kossina, R., Bayguinov, P., Townsend, R. R., Zhang, Q., Erdmann-Gilmore, P., … Kipnis, J. Functional characterization of the dural sinuses as a neuroimmune interface, Cell, January 27, 2021, Read More
Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., Shchukina, I., Kim, M. W., Yuede, C. M., Kipnis, J., Artyomov, M. N., Ulrich, J. D., & Holtzman, D. M. Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy, Nature, March 8, 2023, Read More
Da Mesquita, S., Papadopoulos, Z., Dykstra, T., Brase, L., Farias, F. G., Wall, M., Jiang, H., Kodira, C. D., de Lima, K. A., Herz, J., Louveau, A., Goldman, D. H., Salvador, A. F., Onengut-Gumuscu, S., Farber, E., Dabhi, N., Kennedy, T., Milam, M. G., Baker, W., Smirnov, I., Rich, S. S., Dominantly Inherited Alzheimer Network, Benitez, B. A., Karch, C. M., Perrin, R. J., Farlow, M., Chhatwal, J. P., Holtzman, D. M., Cruchaga, C., Harari, O., & Kipnis, J. Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy, Nature, April 28, 2021, Read More
Paolicelli, R. C., Sierra, A., Stevens, B., et al. Microglia states and nomenclature: A field at its crossroads, Neuron, November 2, 2022, Read More
Drieu, A., Du, S., Kipnis, M., Bosch, M. E., Herz, J., Lee, C., Jiang, H., Manis, M., Ulrich, J. D., Kipnis, J., Holtzman, D. M., & Gratuze, M. Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration, Life Science Alliance, August 10, 2023, Read More