Matthias Nahrendorf, M.D., Ph.D.

Dr. Matthias Nahrendorf is an associate professor at Harvard Medical School and director of the Mouse Imaging Program at the Center for Systems Biology at Massachusetts General Hospital. He completed his joint Ph.D. and M.D. studies at the University of Heidelberg in Germany before moving to the University of Wurzberg, where he did his residency, fellowship and postdoctoral training. Dr. Nahrendorf joined Harvard Medical School in 2004. His laboratory focuses on the cellular and molecular processes in atherosclerosis and after myocardial infarction, using the entire spectrum of imaging modalities, including MRI, nuclear and optical imaging techniques, with a special interest in multimodal imaging. These technologies are embedded in a biologically driven research program that aims at a systematic understanding of inflammation at a basic level while keeping a rigorous translational perspective. 

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kiss, M. G., Mindur, J. E., Yates, A. G., … Nahrendorf, M., … Swirski, F.K. & McAlpine, C. S. Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis, Immunity, May 8, 2023, Read More

Mazzitelli, J. A., Pulous, F. E., Smyth, L. C. D., Kaya, Z., Rustenhoven, J., Moskowitz, M. A., Kipnis, J., & Nahrendorf, M. Skull bone marrow channels as immune gateways to the central nervous system, Nature Neuroscience, November 23, 2023, Read More

Hoyer, F. F., Naxerova, K., Schloss, M. J., Hulsmans, M., Nair, A. V., Dutta, P., Calcagno, D. M., Herisson, F., Anzai, A., Sun, Y., Wojtkiewicz, G., Rohde, D., Frodermann, V., Vandoorne, K., Courties, G., Iwamoto, Y., Garris, C. S., Williams, D. L., Breton, S., Brown, D., Whalen, M., Libby, P., Pittet, M. J., King, K. R., Weissleder, R., Swirski, F. K., & Nahrendorf, M., Tissue-specific macrophage responses to remote injury impact the outcome of subsequent local immune challenges, Immunity, November 19, 2019, Read More

Herisson, F., Frodermann, V., Courties, G., Rohde, D., Sun, Y., Vandoorne, K., Wojtkiewicz, G. R., Masson, G. S., Vinegoni, C., Kim, J., Kim, D. E., Weissleder, R., Swirski, F. K., Moskowitz, M. A., & Nahrendorf, M. Direct Vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration, Nature Neuroscience, August 27, 2018, Read More

McAlpine, C. S., Park, J., Griciuc, A., Kim, E., Choi, S. H., Iwamoto, Y., Kiss, M. G., Christie, K. A., Vinegoni, C., Poller, W. C., Mindur, J. E., Chan, C. T., He, S., Janssen, H., Wong, L. P., Downey, J., Singh, S., Anzai, A., Kahles, F., Jorfi, M., Feruglio, P.F., Sadreyev, R. I., Weissleder, R., Kleinstiver, B. P., Nahrendorf, M., Tanzi, R. E., & Swirski, F. K. Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease, Nature, July 14, 2021, Read More

McAlpine, C. S., Kiss, M. G., Zuraikat, F. M., Cheek, D., Schiroli, G., Amatullah, H., Huynh, P., Bhatti, M. Z., Wong, L. P., Yates, A. G., Poller, W. C., Mindur, J. E., Chan, C. T., Janssen, H., Downey, J., Singh, S., Sadreyev, R. I., Nahrendorf, M., Jeffrey, K. L., Scadden, D. T., Naxerova, K., St-Onge, M., & Swirski, F.K. Sleep exerts lasting effects on hematopoietic stem cell function and diversity, Journal of Experimental Medicine, September 21, 2022, Read More

Janssen, H., Kahles, F., Liu, D., Downey, J., Koekkoek, L. L., Roudko, V., D'Souza, D., McAlpine, C. S., Halle, L., Poller, W. C., Chan, C. T., He, S., Mindur, J. E., Kiss, M. G., Singh, S., Anzai, A., Iwamoto, Y., Kohler, R. H., Chetal, K., Sadreyev, R. I., Weissleder, R., Kim-Schulze, S., Merad, M., Nahrendorf, M., & Swirski, F. K. Monocytes re-enter the bone marrow during fasting and alter the host response to infection, Immunity, February 23, 2023, Read More