Dr. Nikolaos Louros is an Assistant Professor of Biophysics at UT Southwestern Medical Center and a faculty member of the O’Donnell Brain Institute, where he leads a research program focused on understanding and targeting pathological protein aggregation in Alzheimer’s disease and related neurodegenerative disorders. His work integrates biophysics, computational biology, structural analysis, and advanced cell-based systems to define the molecular principles that govern amyloid formation, propagation, and toxicity. Dr. Louros received his doctoral training in molecular biophysics at the National and Kapodistrian University of Athens and completed postdoctoral studies at VIB–KU Leuven, where he developed computational and experimental platforms to study amyloid assembly at residue-level resolution. His research has helped clarify how sequence determinants and structural polymorphism shape disease-associated aggregates and how heterotypic interactions influence amyloid behavior across neurodegenerative conditions. Since establishing his independent laboratory, his lab has documented the prion-like propagation properties of TAF15, a novel protein involved in FTLD, developed ultrasensitive cellular biosensor models, and spearheaded AI-guided protein engineering strategies to design conformation-specific binders and modulators of pathological protein aggregates. His program seeks to translate mechanistic insight into precision diagnostics and structure-guided therapeutic approaches for Alzheimer’s disease and related proteinopathies. He has received multiple national and international awards recognizing his contributions to the amyloid field and is committed to advancing innovative strategies to combat neurodegenerative diseases.

Learn more about his work at the Louros Lab, connect on LinkedIn and X, or visit his faculty profile.