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Randall J. Bateman, M.D.

Charles F. and Joanne Knight Distinguished Professor of Neurology; Director, Dominantly Inherited Alzheimer’s Network (DIAN) and DIAN Trials Unit (DIAN-TU); Washington University School of Medicine in St. Louis 

Dr. Bateman received a B.S. in Electrical Engineering and B.S. in Biology from Washington University and M.D. from Case Western Reserve University School of Medicine. He completed Neurology residency at Barnes Jewish Hospital and postdoctoral research at Washington University School of Medicine. Dr. Bateman is the Charles F. and Joanne Knight Distinguished Professor of Neurology, Director of the Dominantly Inherited Alzheimer Network (DIAN), and Director of the DIAN Trials Unit (DIAN-TU). Dr. Bateman’s research focuses on the pathophysiology and development of improved diagnostics and treatments of Alzheimer’s disease. Dr. Bateman’s lab accomplishments include pioneering the central nervous system Stable Isotope Labeling Kinetics (SILK) measurements in humans, furthering insights of human circadian patterns of amyloid-beta and soluble APP, and human in vivo control of the alpha-secretase, beta-secretase, and gamma-secretase processing of amyloid-beta.

His lab has developed methods to quantify the pharmacodynamic action of drugs targeting amyloid-beta, amyloid precursor protein, and Apolipoprotein E. Dr. Bateman’s research in DIAN has provided evidence for a cascade of events beginning decades before symptom onset that leads to AD dementia. He has received a number of awards including the Beeson Award for Aging Research, Alzheimer’s Association (Zenith Award), Scientific American, Chancellor’s Award for Innovation and Entrepreneurship (Washington University), the Glenn Award for Aging Research, and the MetLife Foundation Award for Medical Research. Dr. Bateman has been the primary mentor for junior faculty, clinical fellows, post-doctoral researchers, and graduate and medical students, who have been successful in their desired scientific careers.

Related Research:

Fleming APOE Consortium: Assessing the Added Diagnostic Value of Peripheral Apolipoprotein E Protein Levels in Current Blood-Based Biomarker Assays for Central Nervous System Amyloidosis Randall J. Bateman 2020-04-13 Amyloid Beta Kinetics and Enhancing the Diagnostic and Prognostic Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease Randall J. Bateman Norelle Wildburger, Ph.D. 2018-08-27 APOE Proteoforms in Human CNS and Validation of APOE Pharmacodynamic Translational Markers Randall J. Bateman 2017-07-25 Orbitrap Fusion Tribrid Mass Spectrometer Randall J. Bateman 2014-08-07

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Fleming APOE Consortium: Assessing the Added Diagnostic Value of Peripheral Apolipoprotein E Protein Levels in Current Blood-Based Biomarker Assays for Central Nervous System Amyloidosis 2020, 2022

$499,999
Amyloid Beta Kinetics and Enhancing the Diagnostic and Prognostic Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease 2017

$50,000
APOE Proteoforms in Human CNS and Validation of APOE Pharmacodynamic Translational Markers 2017 and 2018

$500,000
Orbitrap Fusion Tribrid Mass Spectrometer 2014

$200,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Warmenhoven, N., Salvadó, G., Janelidze, S., Mattsson-Carlgren, N., Bali, D., Orduña Dolado, A., Kolb, H., Triana-Baltzer, G., Barthélemy, N. R., Schindler, S. E., Aschenbrenner, A. J., Raji, C. A., Benzinger, T. L. S., Morris, J. C., Ibanez, L., Timsina, J., Cruchaga, C., Bateman, R. J., Ashton, N., Arslan, B., … Hansson, O. A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker Tests, Brain, October 28, 2024, Read More

Sun, Z., Kwon, J. S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., Valdez, C., Houlden, H., Karch, C. M., Bateman, R. J., Sato, C., Mennerick, S. J., Diamond, M. I., Kim, J., Tanzi, R. E., Holtzman, D. M., Yoo, A. S. Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming, Science, August 8, 2024, Read More

Janelidze, S., Barthélemy, N. R., Salvadó, G., Schindler, S. E., Palmqvist, S., Mattsson-Carlgren, N., Braunstein, J. B., Ovod, V., Bollinger, J. G., He, Y., Li, Y., Raji, C. A., Morris, J. C., Holtzman, D. M., Ashton, N. J., Blennow, K., Stomrud, E., Bateman, R. J., & Hansson, O. Plasma Phosphorylated Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation in People Without Cognitive Impairment, JAMA Neurology, July 28, 2024, Read More

Xiong, C., Luo, J., Wolk, D. A., Shaw, L. M., Roberson, E. D., Murchison, C. F., Henson, R. L., Benzinger, T. L. S., Bui, Q., Agboola, F., Grant, E., Gremminger, E. N., Moulder, K. L., Geldmacher, D. S., Clay, O. J., Babulal, G., Cruchaga, C., Holtzman, D. M., Bateman, R. J., Morris, J. C., Schindler, S. E. Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals, Nature Communications, July 2, 2024, Read More

Chatterjee, M., Özdemir, S., Fritz, C., Möbius, W., Kleineidam, L., Mandelkow, E., ... Bateman, R. J., … Schneider, A. Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS, Nature Medicine, June 18, 2024, Read More

Salvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J., & Hansson, O. Disease staging of Alzheimer’s disease using a CSF-based biomarker model, Nature Aging, March 21, 2024, Read More

Barthélemy, N. R., Salvadó, G., Schindler, S., He, Y., Janelidze, S., Collij, L. E., Saef, B., Henson, R. L., Chen, C. D., Gordon, B. A., Li, Y., La Joie, R., Benzinger, T. L. S., Morris, J. C., Mattsson-Carlgren, N., Palmqvist, S., Ossenkoppele, R., Rabinovici, G. D., Stomrud, E., Bateman, R. J. & Hansson, O. Highly Accurate Blood Test for Alzheimer’s Disease Comparable or Superior to Clinical CSF Tests, Nature Medicine, February 21, 2024, Read More

McDade, E., & Bateman, R. J. Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease Small Windows, Big Picture, JAMA Neurology, May 1, 2018, Read More

Bateman, R. J., Mawuenyega, K. G., & Wildburger, N. C. The structure of amyloid-β dimers in Alzheimer’s disease brain: a step forward for oligomers, Brain, April 29, 2019, Read More

Drieu, A., Du, S., Storck, S. E., Rustenhoven, J., Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., Harari, O., Karch, C. M., Bateman, R. J., Perrin, R., Farlow, M., Chhatwal, J., Dominantly Inherited Alzheimer Network, Hu, S., Randolph, G. J., Smirnov, I., … Kipnis, J. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid, Nature, November 9, 2022, Read More

Roh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J., & Holtzman, D. M. Disruption of the sleep-wake cycle and diurnal fluctuations of amyloid-beta in mice with Alzheimer’s disease pathology, Science Translational Medicine, September 5, 2012, Read More

Kang, J. E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. Amyloid beta dynamics are regulated by orexin and the sleep wake cycle, Science, November 13, 2009, Read More

McDade, E., Voytyuk, I., Aisen, P., Bateman, R. J., Carrillo, M. C., De Strooper, B., Haass, C., Reiman, E. M., Sperling, R., Tariot, P. N., Yan, R., Masters, C. L., Vassar, R., & Lichtenthaler, S. F. The case for low-level BACE1 inhibition for the prevention of Alzheimer disease, Nature Reviews Neurology, September 21, 2021, Read More

Paterson, R. W., Gabelle, A., Lucey, B. P., Barthélemy, N. R., Leckey, C. A., Hirtz, C., Lehmann, S., Sato, C., Patterson, B. W., West, T., Yarasheski, K., Rohrer, J. D., Wildburger, N. C., Schott, J. M., Karch, C. M., Wray, S., Miller, T. M., Elbert, D. L., Zetterberg, H., Fox, N. C., … Bateman, R. J. SILK Studies – Capturing the Turnover of Proteins Linked to Neurodegenerative Diseases, Nature Reviews Neurology, June 20, 2019, Read More

Vermunt, L., Dicks, E., Wang, G., Dincer, A., Flores, S., Keefe, S. J., … Morris. J., C., … Bateman, R. J., ... Dominantly Inherited Alzheimer Network (DIAN) Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer’s disease, Brain Communications, July 15, 2020, Read More

Oxtoby, N. P., Young, A. L., Cash, D. M., Benzinger, T. L. S., Fagan, A. M., Morris, J. C., Bateman, R. J., Fox, N. C., Schott, J. M., & Alexander, D. C. Data-driven models of dominantly-inherited Alzheimer’s disease progression, Brain, March 22, 2018, Read More

Brand, A. L., Lawler, P. E., Bollinger, J. G., Li, Y., Schindler, S. E., Li, M., Lopez, S., Ovod, V., Nakamura, A., Shaw, L. M., Zetterberg, H., Hansson, O., & Bateman, R. J. The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature review, Alzheimer's Research & Therapy, December 27, 2022, Read More

Esparza, T. J., Wildburger, N. C., Jiang, H., Gangolli, M., Cairns, N. J., Bateman, R. J., & Brody, D. L. Solble Amyloid-beta aggregates from human Alzheimr’s disease brains, Scientific Reports, December 5, 2016, Read More

Wildburger, N. C., Esparza, T. J., LeDuc, R. D., Fellers, R. T., Thomas, P. M., Cairns, N. J., Kelleher, N. L., Bateman, R. J., & Brody, D. L. Diversity of amyloid-beta proteoforms in the Alzheimer’s disease brain, Scientific Reports, August 25, 2017, Read More

Vöglein, J., Paumier, K., Jucker, M., Preische, O., McDade, E., Hassenstab, J., Benzinger, T. L., Noble, J. M., Berman, S. B., Graff-Radford, N. R., Ghetti, B., Farlow, M. R., Chhatwal, J., Salloway, S., Xiong, C., Karch, C. M., Cairns, N., Mori, H., Schofield, P. R., Masters, C. L., … Dominantly Inherited Alzheimer Network Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease, Brain, March 20, 2019, Read More

Schindler, S. E., Karikari, T. K., Ashton, N. J., Henson, R. L., Yarasheski, K. E., West, T., Meyer, M. R., Kirmess, K. M., Li, Y., Saef, B., Moulder, K. L., Bradford, D., Fagan, A. M., Gordon, B. A., Benzinger, T. L. S., Balls-Berry, J., Bateman, R. J., Xiong, C., Zetterberg, H., Blennow, K., … Morris, J. C. Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light, Neurology, April 21, 2022, Read More

Barthélemy, N. R., Saef, B., Li, Y., Gordon, B. A., He, Y., Horie, K., Stomrud, E., Salvadó, G., Janelidze, S., Sato, C., Ovod, V., Henson, R. L., Fagan, A. M., Benzinger, T. L. S., Xiong, C., Morris, J. C., Hansson, O., Bateman, R. J., & Schindler, S. E. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease, Nature Aging, March 13, 2023, Read More

Horie, K., Salvadó, G., Barthélemy, N. R., Janelidze, S., Li, Y., He, Y., Saef, B., Chen, C. D., Jiang, H., Strandberg, O., Pichet Binette, A., Palmqvist, S., Sato, C., Sachdev, P., Koyama, A., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Mattsson-Carlgren, N., … Bateman, R. J. CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease, Nature Medicine, July 13, 2023, Read More

Esparza, T. J., Zhao, H., Cirrito, J. R., Cairns, N. J., Bateman, R. J., Holtzman, D. M., & Brody, D. L. Amyloid beta oligomerization in Alzheimer’s dementia versus high pathology controls, Annals of Neurology, January 1, 2013, Read More

Lawler, P. E., Bollinger, J. G., Schindler, S. E., Hodge, C. R., Iglesias, N. J., Krishnan, V., Coulton, J. B., Li, Y., Holtzman, D. M., & Bateman, R. J. Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype, Analytical Biochemistry, April 16, 2023, Read More

Ovod, V., Ramsey, K. N., Mawuenyega, K. G., Bollinger, J. G., Hicks, T., Schneider, T., Sullivan, M., Paumier, K., Holtzman, D. M., Morris, J. C., Benzinger, T., Fagan, A. M., Patterson, B. W., & Bateman, R. J. Amyloid beta concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis, Alzheimer's & Dementia, July 19, 2017, Read More

Suárez-Calvet, M., Araque Caballero, M. Á., Kleinberger, G., Bateman, R. J., Fagan, A. M., Morris, J. C., Levin, J., Danek, A., Ewers, M., & Haass, C. Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury, Science Translational Medicine, December 14, 2016, Read More

Capano, L. S., Sato, C., Ficulle, E., Yu, A., Horie, K., Kwon, J. S., Burbach, K. F., Barthélemy, N. R., Fox, S. G., Karch, C. M., Bateman, R. J., Houlden, H., Morimoto, R. I., Holtzman, D. M., Duff, K. E., & Yoo, A. S. Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons, Cell Stem Cell, June 2, 2022, Read More

Kinnunen, K. M., Cash, D. M., Poole, T., Frost, C., Benzinger, T. L. S., Ahsan, R. L., Leung, K. K., Cardoso, M. J., Modat, M., Malone, I. B., Morris, J. C., Bateman, R. J., Marcus, D. S., Goate, A., Salloway, S. P., Correia, S., Sperling, R. A., Chhatwal, J. P., Mayeux, R. P., Brickman, A. M., Martins, R. N., Farlow, M. R., Ghetti, B., Saykin, A. J., Jack, Jr., C. R., Schofield, P. R., McDade, E., Weiner, M. W., Ringman, J. M., Thompson, P. M., Masters, C. L., Rowe, C. C., Rossor, M. N., Ourselin, S., & Fox, N. C. Presymptomatic atrophy in autosomal dominant Alzheimer’s disease: a serial magnetic resonance imaging study, Alzheimer's & Dementia, July 22, 2017, Read More

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