Dr. Stephen J. Elledge is the Gregor Mendel Professor of Genetics and Medicine at Harvard Medical School and Brigham and Women’s Hospital. A leading geneticist, Dr. Elledge has pioneered research using yeast and mammalian systems to uncover fundamental mechanisms of cellular regulation and genome integrity. His laboratory elucidated how cells detect and respond to DNA damage and identified the F-box proteins, Skp1, and the SCF ubiquitin ligase family that govern protein stability. With Dr. Wade Harper, his group also discovered the Cdk inhibitors p21 and p57, defining their critical roles in cell cycle control, development, and cancer. His group additionally identified IFITM3 as a restriction factor that inhibits influenza, West Nile, and dengue viruses. Dr. Elledge developed VirScan, a technology that profiles an individual’s history of viral infection from a single drop of blood, revealing, among other findings, that measles infection erases immune memory. He also created TSCAN, which identifies T-cell targets across the genome and virome, advancing our understanding of immune recognition and response.