Rik Ossenkoppele, Ph.D.

Associate Professor in Translational Neuroscience and Principal Investigator, the Alzheimercenter Amsterdam of the Amsterdam University Medical Center, the Netherlands, and at Lund University in Sweden


Rik Ossenkoppele is an associate professor in Translational Neuroscience and PI at the Alzheimercenter Amsterdam of the Amsterdam UMC and at Lund University in Sweden. He works on the intersection between neuroimaging, biomarkers and cognition in Alzheimer’s disease. His main motivation is to contribute to improving the diagnostic/prognostic work-up (short-term goal) and curing AD (long-term goal). Dr. Ossenkoppele received several prestigious prices (e.g., the European Grand Prix for Research on the Foundation of Alzheimer’s Disease [2019], the Young Investigator Research award from Alzheimer Nederland [2020] and the Queen Silvia Research Prize [2021]) and research grant (e.g., an ERC starting grant and various dementia research grants). He is also an associate editor for Alzheimer’s Research & Therapy, program committee member for several AD and FTD imaging conferences and Vice Chair for the Atypical AD Professional Interest Areas of the Alzheimer Association.

www.alzheimercentrum.nl

www.biofinder.se

@RikOssenkoppele, @biofinder_study

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Oomens, J. E., Vos, S. J., Maserejian, N. N., Boada, M., Didic, M., ... Scheltens, P., ... Zetterberg, H., ... Bateman, R. J., ... Ossenkoppele, R., … Jansen, W. J. Associations of lifestyle factors with amyloid pathology in persons without dementia, Journal of Alzheimer's Disease, November 13, 2025, Read More

Mastenbroek, S. E., Collij, L. E., Anijärv, T. E., Rittmo, J., Young, A. L., Strandberg, O., Smith, R., Spotorno, N., Palmqvist, S., Mattsson-Carlgren, N., Janelidze, S., Parchi, P., Vogel, J. W., Barkhof, F., Ossenkoppele, R., & Hansson, O. Biological classification of memory clinic patients, Brain, October 29, 2025, Read More

Salvadó, G., Janelidze, S., Bali, D., Dolado, A. O., Therriault, J., … Petersen, R. C., Jack, C. R., Jr., Schindler, S. E., Suárez-Calvet, M., Ossenkoppele, R., Hansson, O., for the ADNI, ALFA, and PREVENT-AD Study Groups Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease, JAMA Neurology, September 15, 2025, Read More

Bocancea, D. I., van Loenhoud, A. C., Kuijper, B., Calandri, I. L., Groot, C., Venkatraghavan, V., de Boer, C., Ten Kate, M., Trieu, C., Teunissen, C. E., van de Giessen, E., Leeuwis, A. E., Schlueter, L. M., van Harten, A. C., Pijnenburg, Y. A. L., Barkhof, F., van der Flier, W. M., & Ossenkoppele, R. Cognitive and physical activities are associated with cognitive resilience in a memory clinic cohort, Brain Communications, September 6, 2025, Read More

Anijärv, T. E., Ossenkoppele, R., Smith, R., Pichet Binette, A., Collij, L. E., Behjat, H. H., Rittmo, J., Karlsson, L., Ahmadi, K., Strandberg, O., Alzheimer’s Disease Neuroimaging Initiative, van Westen, D., Vogel, J. W., Stomrud, E., Palmqvist, S., Mattsson-Carlgren, N., Spotorno, N., & Hansson, O. Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer’s Disease, Nature Communications, September 5, 2025, Read More

de Bruin, H., Groot, C., Barthel, H., Bischof, G. N., … Hansson, O. … Ossenkoppele, R. Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease, Brain, August 14, 2025, Read More

Mastenbroek, S. E., Collij, L. E., Vogel, J. W., Caldera, S., Serrano, G. E., Adler, C. H., Vargiu, C. M., Palmqvist, S., Barkhof, F., Parchi, P., Beach, T. G., Ossenkoppele, R., & Hansson, O. Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification, Nature Communications, August 5, 2025, Read More

Singleton, E. H., Mattsson-Carlgren, N., Pichet Binette, A., Stomrud, E., Strandberg, O., Palmqvist, S., Ossenkoppele, R., & Hansson, O. Longitudinal tau aggregation, atrophy, and cognitive decline in Alzheimer’s diseas, Alzheimer's & Dementia, July 8, 2025, Read More

Carrigan, M., Bocancea, D. I., Vogel, J., van Loenhoud, A. C., Tesi, N., Barkhof, F., Lucassen, P. J., van der Flier, W. M., Krugers, H. J., Van der Lee, S. J., & Ossenkoppele, R. A novel approach to resilience and its links with education and Alzheimer’s disease genetics, Alzheimer's & Dementia, July 4, 2025, Read More

Janelidze, S., Collij, L. E., Mattsson-Carlgren, N., Antill, A., Laymon, C. M., Lott, I., Rosas, H. D., Minhas, D. S., Luo, W., Zaman, S., Alzheimer's Biomarker Consortium–Down Syndrome investigators, Mapstone, M., Head, E., Lai, F., Hartley, S. L., Ances, B. M., Krinsky-McHale, S. J., Lee, J. H., Ossenkoppele, R., Christian, B. T., … Hansson, O. Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study, The Lancet Neurology, June 18, 2025, Read More

Moscoso, A., Heeman, F., Raghavan, S., Costoya-Sánchez, A., van Essen, M., ... Ossenkoppele, R., ...Hansson, O., ... Petersen, R. C., … PREVENT-AD Research Group, the Harvard Aging Brain Study, the LEADS Consortium, and the Alzheimer’s Disease Neuroimaging Initiative Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity, JAMA, June 16, 2025, Read More

Coomans, E. M., van Tol, B., Groot, C., Smith, R., Palmqvist, S., Stomrud, E., Pontecorvo, M. J., Shcherbinin, S., Kennedy, I., Kotari, V., van der Flier, W. M., Pijnenburg, Y. A. L., Mattsson-Carlgren, N., Hansson, O., van de Giessen, E., & Ossenkoppele, R. Quantitation of PET spatial extent as a potential adjunct to visual interpretation of [18F]flortaucipir imaging: TAU-SPEX, European Journal of Nuclear Medicine and Molecular Imaging, June 7, 2025, Read More

Pichet Binette, A., Smith, R., Salvadó, G., Tideman, P., Glans, I., van Westen, D., Groot, C., Ossenkoppele, R., Stomrud, E., Parchi, P., Zetterberg, H., Blennow, K., Mattsson-Carlgren, N., Janelidze, S., Palmqvist, S., Hansson, O., & Alzheimer’s Disease Neuroimaging Initiative Evaluation of the Revised Criteria for Biological and Clinical Staging of Alzheimer Disease, JAMA Neurology, May 19, 2025, Read More

Palmqvist, S., Warmenhoven, N., Anastasi, F., Pilotto, A., Janelidze, S., Tideman, P., Stomrud, E., Mattsson-Carlgren, N., Smith, R., Ossenkoppele, R., Tan, K., Dittrich, A., Skoog, I., Zetterberg, H., … Hansson, O. Plasma phospho-tau217 for Alzheimer’s disease diagnosis in primary and secondary care using a fully automated platform, Nature Medicine, April 9, 2025, Read More

Horie, K., Salvadó, G., Koppisetti, R. K., Janelidze, S., Barthélemy, N. R., He, Y., Sato, C., Gordon, B. A., Jiang, H., Benzinger, T. L. S., Stomrud, E., Holtzman, D. M., Mattsson-Carlgren, N., Morris, J. C., Palmqvist, S., Ossenkoppele, R., Schindler, S. E., Hansson, O., & Bateman, R. J. Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer’s disease, Nature Medicine, March 31, 2025, Read More

Ossenkoppele, R., Salvadó, G., Janelidze, S., Pichet Binette, A., Bali, D., ... Bateman R. J., ... Petersen, R. C, Jack, C. R., Jr, & Hansson, O. Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials, Nature Aging, March 28, 2025, Read More

Kamps, S., Hempel, H. L., van Amerongen, S., de Bruin, H., van der Linden, F. H. C., Venkatraghavan, V., van der Flier, W. M., Pijnenburg, Y. A. L., Barkhof, F., Scheltens, P., Ossenkoppele, R., & Vijverberg, E. G. B. Enlarged cavum septum pellucidum as a neuroimaging signature of head impact exposure, Brain Communications, February 21, 2025, Read More

Oomens, J. E., van Gils, V., Vos, S. J. B., Freeze, W. M., Maserejian, N. N., ... Zetterberg, H., ... Ossenkoppele, R., … BIOFACE Study Group Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study, JAMA Network Open, January 22, 2025, Read More

Svenningsson, A. L., Bocancea, D. I., Stomrud, E., van Loenhoud, A., Barkhof, F., Mattsson-Carlgren, N., Palmqvist, S., Hansson, O., & Ossenkoppele, R. Biological mechanisms of resilience to tau pathology in Alzheimer’s disease, Alzheimer's Research & Therapy, October 12, 2024, Read More

Collij, L. E., Mastenbroek, S. E., Mattsson-Carlgren, N., Strandberg, O., Smith, R., Janelidze, S., Palmqvist, S., Ossenkoppele, R., & Hansson, O. Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease, Nature Communications, September 14, 2024, Read More

Palmqvist, S., Tideman, P., Mattsson-Carlgren, N., Schindler, S. E., Smith, R., Ossenkoppele, R., Calling, S., West, T., Monane, M., Verghese, P. B., Braunstein, J. B., Blennow, K., Janelidze, S., Stomrud, E., Salvadó, G., & Hansson, O. Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care, JAMA, July 28, 2024, Read More

Leuzy, A., Raket, L. L., Villemagne, V. L., Klein, G., Tonietto, M., … Petersen, R. C., ... Ossenkoppele, R., ... Hansson, O., ... Doré, V. Harmonizing tau positron emission tomography in Alzheimer’s disease: The CenTauR scale and the joint propagation model, Alzheimer's & Dementia, July 23. 2024, Read More

Soleimani-Meigooni, D. N., Smith, R., Provost, K., Lesman-Segev, O. H., Allen, I. E., Chen, M. K., Cho, H., Edwards, L., Janelidze, S., La Joie, R., Mundada, N., Ossenkoppele, R., Stomrud, E., Strandberg, O., Strom, A., Boxer, A. L., Dage, J. L., Gorno-Tempini, M. L., Kramer, J. H., Miller, B. L., …, Hansson, O., Rabinovici, G. D. Head-to-Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study, Annals of Neurology, June 18, 2024, Read More

Mastenbroek, S. E., Vogel, J. W., Collij, L. E., Serrano, G. E., Tremblay, C., Young, A. L., Arce, R. A., Shill, H. A., Driver-Dunckley, E. D., Mehta, S. H., Belden, C. M., Atri, A., Choudhury, P., Barkhof, F., Adler, C. H., Ossenkoppele, R., Beach, T. G., & Hansson, O. Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology, Nature Communications, June 15, 2024, Read More

Groot, C., Smith, R., Collij, L. E., Mastenbroek, S. E., Stomrud, E., Binette, A. P., Leuzy, A., Palmqvist, S., Mattsson-Carlgren, N., Strandberg, O., Cho, H., Lyoo, C. H., Frisoni, G. B., Peretti, D. E., Garibotto, V., La Joie, R., Soleimani-Meigooni, D. N., Rabinovici, G., Ossenkoppele, R., & Hansson, O. Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment, JAMA Neurology, June 10, 2024, Read More

Salvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J., & Hansson, O. Disease staging of Alzheimer’s disease using a CSF-based biomarker model, Nature Aging, March 21, 2024, Read More

Barthélemy, N. R., Salvadó, G., Schindler, S., He, Y., Janelidze, S., Collij, L. E., Saef, B., Henson, R. L., Chen, C. D., Gordon, B. A., Li, Y., La Joie, R., Benzinger, T. L. S., Morris, J. C., Mattsson-Carlgren, N., Palmqvist, S., Ossenkoppele, R., Rabinovici, G. D., Stomrud, E., Bateman, R. J. & Hansson, O. Highly Accurate Blood Test for Alzheimer’s Disease Comparable or Superior to Clinical CSF Tests, Nature Medicine, February 21, 2024, Read More

Young, A. L., Vogel, J. W., Robinson, J. L., McMillan, C. T., Ossenkoppele, R., Wolk, D. A., Irwin, D. J., Elman, L., Grossman, M., Lee, V. M., Lee, E. B., & Hansson, O. Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies, Brain, May 8, 2023, Read More

Coomans, E. M., van Westen, D., Pichet Binette, A., Strandberg, O., Spotorno, N., Serrano, G. E., Beach, T. G., Palmqvist, S., Stomrud, E., Ossenkoppele, R., & Hansson, O. Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation, Brain, September 18, 2023, Read More

Bocancea, D. I., Svenningsson, A. L., van Loenhoud, A. C., Groot, C., Barkhof, F., Strandberg, O., Smith, R., Alzheimer’s Disease Neuroimaging Initiative, La Joie, R., Rosen, H. J., Pontecorvo, M. J., Rabinovici, G. D., van der Flier, W. M., Hansson, O., & Ossenkoppele, R. Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis, Brain, March 27, 2023, Read More

Zheng, L., Rubinski, A., Denecke, J., Luan, Y., Smith, R., Strandberg, O., Stomrud, E., Ossenkoppele, R., Svaldi, D. O., Higgins, I. A., Shcherbinin, S., Pontecorvo, M. J., Hansson, O., Franzmeier, N., Ewers, M., & Alzheimer's Disease Neuroimaging Initiative Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease, Annals of Neurology, October 14, 2023, Read More

Horie, K., Salvadó, G., Barthélemy, N. R., Janelidze, S., Li, Y., He, Y., Saef, B., Chen, C. D., Jiang, H., Strandberg, O., Pichet Binette, A., Palmqvist, S., Sato, C., Sachdev, P., Koyama, A., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Mattsson-Carlgren, N., … Bateman, R. J. CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease, Nature Medicine, July 13, 2023, Read More

Mattsson-Carlgren, N., Collij, L. E., Stomrud, E., Pichet Binette, A., Ossenkoppele, R., Smith, R., Karlsson, L., Lantero-Rodriguez, J., Snellman, A., Strandberg, O., Palmqvist, S., Ashton, N. J., Blennow, K., Janelidze, S., & Hansson, O. Plasma Biomarker Strategy for Selecting Patients With Alzheimer Disease for Antiamyloid Immunotherapies, JAMA Neurology, December 4, 2023, Read More