Henrik Zetterberg, M.D., Ph.D.

Professor of Neurochemistry, University of Gothenburg, Sweden and University College London, UK; Clinical Chemist, Sahlgrenska University Hospital, Gothenburg, Sweden


Henrik Zetterberg is a Professor of Neurochemistry at the University of Gothenburg, Sweden, and University College London, UK, and a Clinical Chemist at Sahlgrenska University Hospital in Gothenburg, Sweden. He is Head of the Department of Psychiatry and Neurochemistry at the University of Gothenburg, leads the UK DRI Fluid Biomarker Laboratory at UCL, and is a Key Member of the Hong Kong Center for Neurodegenerative Diseases and a Visiting Professor in the UW Department of Medicine, School of Medicine and Public Health, Madison, Wisconsin. His main research focus and clinical interest are fluid biomarkers for brain diseases, neurodegenerative diseases in particular. He has published more than 1,800 scientific articles and received many awards.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

1. Rea Reyes, R. E., Cody, K. A., Wilson, R. E., Zetterberg, H., Chin, N. A., Jonaitis, E. M., Bahr, M., Mandel, O., Wintlend, M., Bendlin, B. B., Okonkwo, O. C., Clark, L. R., Zammit, M., Asthana, S., Christian, B. T., Betthauser, T. J., Eisenmenger, L., Langhough, R. E., & Johnson, S. C. Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer’s disease, Alzheimer's & Dementia, November 19, 2024, Read More

Simrén, J., Ashton, N. J., Suárez-Calvet, M., & Zetterberg, H. Alzheimer’s disease—Biomarkers, clinical evaluation or both?, Journal of Neuropsychology, November 14, 2024, Read More

2. Therriault, J., Janelidze, S., Benedet, A. L., Ashton, N. J., Arranz Martínez, J., Gonzalez-Escalante, A., Bellaver, B., Alcolea, D., Vrillon, A., Karim, H., Mielke, M. M., … Petersen, R. C., … Zetterberg, H., … Hansson, O., & Rosa-Neto, P. Diagnosis of Alzheimer’s disease using plasma biomarkers adjusted to clinical probability, Nature Aging, November 12, 2024, Read More

Woo, M. S., Therriault, J., Jonaitis, E. M., Wilson, R., Langhough, R. E., Rahmouni, N., Benedet, A. L., Ashton, N. J., Tissot, C., Lantero-Rodriguez, J., Macedo, A. C., Servaes, S., Wang, Y. T., Arias, J. F., Hosseini, S. A., Betthauser, T. J., Lussier, F. Z., Hopewell, R., Triana-Baltzer, G., Kolb, H. C., … Rosa-Neto, P. Identification of late-stage tau accumulation using plasma phospho-tau217, eBioMedicine, November 4, 2024, Read More

Safransky, M., Groh, J. R., Blennow, K., Zetterberg, H., Tripodis, Y., Martin, B., Weller, J., Asken, B. M., Rabinovici, G. D., Qiu, W. W. Q., McKee, A. C., Stein, T. D., Mez, J., Henson, R. L., Long, J., Morris, J. C., Perrin, R. J., Schindler, S. E., & Alosco, M. L. Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease, Neurology, November 4, 2024, Read More

Olofsson, J., Bergström, S., Mravinacová, S., Kläppe, U., Öijerstedt, L., Zetterberg, H., Blennow, K., Ingre, C., Nilsson, P., & Månberg, A. Cerebrospinal fluid levels of NfM in relation to NfL and pNfH as prognostic markers in amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, November 2, 2024, Read More

Aye, S., Frisell, O., Zetterberg, H., Skillbäck, T. B., Kern, S., Eriksdotter, M., Aho, E., Xia, X., Winblad, B., Wimo, A., & Jönsson, L. Costs of Care in Relation to Alzheimer’s Disease Severity in Sweden: A National Registry-Based Cohort Study, PharmacoEconomics, November 1, 2024, Read More

Warmenhoven, N., Salvadó, G., Janelidze, S., Mattsson-Carlgren, N., Bali, D., Orduña Dolado, A., Kolb, H., Triana-Baltzer, G., Barthélemy, N. R., Schindler, S. E., Aschenbrenner, A. J., Raji, C. A., Benzinger, T. L. S., Morris, J. C., Ibanez, L., Timsina, J., Cruchaga, C., Bateman, R. J., Ashton, N., Arslan, B., … Hansson, O. A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker Tests, Brain, October 28, 2024, Read More

Al-Diwani, A., Provine, N. M., Murchison, A., Laban, R., Swann, O. J., Koychev, I., Sheerin, F., Da Mesquita, S., Heslegrave, A., Zetterberg, H., Klenerman, P., & Irani, S. R. Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes, Brain, October 21, 2024, Read More

Götze, K., Vrillon, A., Dumurgier, J., Indart, S., Sanchez-Ortiz, M., Slimi, H., Raynaud-Simon, A., Cognat, E., Martinet, M., Zetterberg, H., Blennow, K., Hourrègue, C., Bouaziz-Amar, E., Paquet, C., & Lilamand, M. Plasma neurofilament light chain as prognostic marker of cognitive decline in neurodegenerative diseases, a clinical setting study, Alzheimer's Research & Therapy, October 19, 2024, Read More

Miner, A. E., Groh, J. R., Tripodis, Y., Adler, C. H., Balcer, L. J., Bernick, C., Zetterberg, H., Blennow, K., Peskind, E., Ashton, N. J., Gaudet, C. E., Martin, B., Palmisano, J. N., Banks, S. J., Barr, W. B., Wethe, J. V., Cantu, R. C., Dodick, D. W., Katz, D. I., Mez, J., … DIAGNOSE CTE Research Project Examination of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in former elite American football players, Alzheimer's & Dementia, October 1, 2024, Read More

Johansson, C., Thordardottir, S., Laffita-Mesa, J., Pannee, J., Rodriguez-Vieitez, E., Zetterberg, H., Blennow, K., & Graff, C. Gene-variant specific effects of plasma amyloid-β levels in Swedish autosomal dominant Alzheimer disease, Alzheimer's Research & Therapy, September 25, 2024, Read More

Leuzy, A., Heeman, F., Bosch, I., Lenér, F., Dottori, M., Quitz, K., Moscoso, A., Kern, S., Zetterberg, H., Blennow, K., & Schöll, M. REAL AD—Validation of a realistic screening approach for early Alzheimer’s disease, Alzheimer's & Dementia, September 23, 2024, Read More

Sandgren, S., Novakova, L., Nordin, A., Sabir, H., Axelsson, M., Malmeström, C., Zetterberg, H., & Lycke, J. The effect of alemtuzumab on neurodegeneration in relapsing-remitting multiple sclerosis: A five-year prospective mono-center study, Multiple Sclerosis and Related Disorders, September 13, 2024, Read More

Borda, M. G., Barreto, G. E., Baldera, J. P., de Lucia, C., Khalifa, K., Bergland, A. K., Pola, I., Botero-Rodríguez, F., Siow, R. C., Kivipelto, M., Zetterberg, H., Ashton, N. J., Ballard, C., Aarsland, D., & NJ FINGER A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: Analysis of inflammatory biomarkers toward personalized interventions, Experimental Gerontology, September 9, 2024, Read More

Li, Y., Luo, L., Senicar, L., Asrosa, R., Kizilates, B., Xing, K., Torres, E., Xu, L., Li, D., Graham, N., Heslegrave, A., Zetterberg, H., Sharp, D. J., & Li, B. An Ultrasensitive Molecularly Imprinted Point-Of-Care Electrochemical Sensor for Detection of Glial Fibrillary Acidic Protein, Advanced Healthcare Materials, September 2, 2024, Read More

Koetsier, J., Cavill, R., Reijnders, R., Harvey, J., Homann, J., … Dobricic, V., … Scheltens, P., … Zetterberg, H., … Lill, C. L., Bertram, L., … Pishva, E. Blood-based multivariate methylation risk score for cognitive impairment and dementia, Alzheimer's & Dementia, August 28, 2024, Read More

Quaresima, V., Pilotto, A., Trasciatti, C., Tolassi, C., Parigi, M., Bertoli, D., Mordenti, C., Galli, A., Rizzardi, A., Caratozzolo, S., Benussi, A., Ashton, N. J., Blennow, K., Zetterberg, H., Giliani, S., Brugnoni, D., & Padovani, A. Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA, Neurology of Aging, August 28, 2024, Read More

Quaresima, V., Pilotto, A., Trasciatti, C., Tolassi, C., Parigi, M., Bertoli, D., Mordenti, C., Galli, A., Rizzardi, A., Caratozzolo, S., Benussi, A., Ashton, N. J., Blennow, K., Zetterberg, H., Giliani, S., Brugnoni, D., & Padovani, A. Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA, Neurobiology of Aging, August 22, 2024, Read More

Di Filippo, M., Gaetani, L., Centonze, D., Hegen, H., Kuhle, J., Teunissen, C. E., Tintoré, M., Villar, L. M., Willemse, E. A. J., Zetterberg, H., & Parnetti, L. Fluid biomarkers in multiple sclerosis: from current to future applications, The Lancet Regional Health Europe, August 22, 2024, Read More

Malpetti, M., Swann, P., Tsvetanov, K. A., Chouliaras, L., Strauss, A., Chikaura, T., Murley, A. G., Ashton, N. J., Barker, P., Jones, P. S., Fryer, T. D., Hong, Y. T., Cope, T. E., Savulich, G., Street, D., Bevan-Jones, W. R., Rittman, T., Blennow, K., Zetterberg, H., Aigbirhio, F. I., … Rowe, J. B. Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration, Brain, August 19, 2024, Read More

Zhang, Z., Xue, P., Bendlin, B. B., Zetterberg, H., De Felice, F., Tan, X., & Benedict, C. Melatonin: A potential nighttime guardian against Alzheimer’s, Molecular Psychiatry, August 11, 2024, Read More

Emeršič, A., Karikari, T. K., Kac, P. R., Gonzalez-Ortiz, F., Dulewicz, M., Ashton, N. J., Brecl Jakob, G., Horvat Ledinek, A., Hanrieder, J., Zetterberg, H., Rot, U., Čučnik, S., & Blennow, K. Biomarkers of tau phosphorylation state are associated with the clinical course of multiple sclerosis, Multiple sclerosis and related disorders, August 5, 2024, Read More

Ivanova, K., Zolovs, M., Blennow, K., Zetterberg, H., Kurjāne, N., & Ķēniņa, V. Polyneuropathy in systemic sclerosis: exploring the causes and biomarkers, Frontiers in Medicine, August 1, 2024, Read More

Fernström, E., Jarfelt, M., Blomstrand, M., Lannering, B., Axelsson, M., Wasling, P., Björk-Eriksson, T., Zetterberg, H., & Kalm, M. CSF biomarkers of neurotoxicity in childhood cancer survivors after cranial radiotherapy or surgery, Annals of Clinical and Translational Neurology, July 19, 2024, Read More

Lantero-Rodriguez, J., Camporesi, E., Montoliu-Gaya, L., Gobom, J., Piotrowska, D., Olsson, M., Burmann, I. M., Becker, B., Brinkmalm, A., Burmann, B. M., Perkinton, M., Ashton, N. J., Fox, N. C., Lashley, T., Zetterberg, H., Blennow, K., & Brinkmalm, G. Tau protein profiling in tauopathies: a human brain study, Molecular Neurodegeneration, July 19, 2024, Read More

Kasri, A., Camporesi, E., Gkanatsiou, E., Boluda, S., Brinkmalm, G., Stimmer, L., Ge, J., Hanrieder, J., Villain, N., Duyckaerts, C., Vermeiren, Y., Pape, S. E., Nicolas, G., Laquerrière, A., De Deyn, P. P., Wallon, D., Blennow, K., Strydom, A., Zetterberg, H., & Potier, M. C. Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome, Acta Neuropathologica, July 18, 2024, Read More

Doroszkiewicz, J., Kulczyńska-Przybik, A., Dulewicz, M., Mroczko, J., Borawska, R., Słowik, A., Zetterberg, H., Hanrieder, J., Blennow, K., & Mroczko, B. Associations between Microglia and Astrocytic Proteins and Tau Biomarkers across the Continuum of Alzheimer’s Disease, International Journal of Molecular Sciences, July 9, 2024, Read More

Delvenne, A., Gobom, J., Schindler, S. E., Kate, M. T., Reus, L. M., Dobricic, V., Tijms, B. M., Benzinger, T. L. S., Cruchaga, C., ... Bertram, L., … Zetterberg, H., ... Vos, S. J. B. CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer’s disease, Alzheimer's & Dementia, July 6, 2024, Read More

Zarkali, A., Thomas, G. E. C., Zetterberg, H., & Weil, R. S. Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions, Nature Communications, July 5, 2024, Read More

Du, L., Langhough, R. E., Wilson, R. E., Reyes, R. E. R., Hermann, B. P., Jonaitis, E. M., Betthauser, T. J., Chin, N. A., Christian, B., Chaby, L., Jeromin, A., Molfetta, G. D., Brum, W. S., Arslan, B., Ashton, N., Blennow, K., Zetterberg, H., & Johnson, S. C. Longitudinal plasma phosphorylated-tau217 and other related biomarkers in a non-demented Alzheimer’s risk-enhanced sample, Alzheimer's & Dementia, July 5, 2024, Read More

Andriuta, D., Ottoy, J., Ruthirakuhan, M., Feliciano, G., Dilliott, A. A., … Zetterberg, H., ... ONDRI Investigators Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases, Alzheimer's & Dementia, July 4, 2024, Read More

Peretti, D. E., Boccalini, C., Ribaldi, F., Scheffler, M., Marizzoni, M., Ashton, N. J., Zetterberg, H., Blennow, K., Frisoni, G. B., & Garibotto, V. Association of glial fibrillary acid protein, Alzheimer’s disease pathology and cognitive decline, Brain, June 28, 2024, Read More

Orduña Dolado, A., Stomrud, E., Ashton, N. J., Nilsson, J., Quijano-Rubio, C., Jethwa, A., Brum, W. S., Brinkmalm Westman, A., Zetterberg, H., Blennow, K., Janelidze, S., & Hansson, O. Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers, Alzheimer's Research & Therapy, June 22, 2024, Read More

Beckers, E., Van Egroo, M., Ashton, N. J., Blennow, K., Vandewalle, G., Zetterberg, H., Poser, B. A., & Jacobs, H. I. L. Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study, Cerebral Cortex, 6/21/2024, Read More

Princen, K., Van Dooren, T., van Gorsel, M., Louros, N., Yang, X., … Zetterberg, H., ... Griffioen, G. Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer’s disease, Science, May 31, 2024, Read More

De Meyer, S., Schaeverbeke, J. M., Luckett, E. S., Reinartz, M., Blujdea, E. R., Cleynen, I., Dupont, P., Van Laere, K., Vanbrabant, J., Stoops, E., Vanmechelen, E., di Molfetta, G., Zetterberg, H., Ashton, N. J., Teunissen, C. E., Poesen, K., & Vandenberghe, R. Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET, Brain Communications, May 23, 2024, Read More

Jacobs, T., Jacobson, S. R., Fortea, J., Berger, J. S., Vedvyas, A., Marsh, K., He, T., Gutierrez-Jimenez, E., Fillmore, N. R., Gonzalez, M., Figueredo, L., Gaggi, N. L., Plaska, C. R., Pomara, N., Blessing, E., Betensky, R., Rusinek, H., Zetterberg, H., Blennow, K., Glodzik, L., … Alzheimer’s Disease Neuroimaging Initiative The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people, Immunity & Ageing, May 17, 2024, Read More

Gard, A., Kornaropoulos, E. N., Portonova Wernersson, M., Rorsman, I., Blennow, K., Zetterberg, H., Tegner, Y., De Maio, A., Markenroth Bloch, K., Björkman-Burtscher, I., Pessah-Rasmussen, H., Nilsson, M., & Marklund, N. Widespread White Matter Abnormalities in Concussed Athletes Detected by 7T Diffusion Magnetic Resonance Imaging, Journal of Neurotrauma, May 3, 2024, Read More

Gadd, G., Åberg, D., Wall, A., Zetterberg, H., Blennow, K., Jood, K., Jern, C., Isgaard, J., Svensson, J., & Åberg, N. D. Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome-The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1, International Journal of Molecular Sciences, April 30, 2024, Read More

Fruhwürth, S., Zetterberg, H., & Paludan, S. R. Microglia and amyloid plaque formation in Alzheimer’s disease – Evidence, possible mechanisms, and future challenges, Journal of Neuroinflammation, April 4, 2024, Read More

Brum, W. S., Cullen, N. C., Therriault, J., Janelidze, S., Rahmouni, N., Stevenson, J., Servaes, S., Benedet, A. L., Zimmer, E. R., Stomrud, E., Palmqvist, S., Zetterberg, H., Frisoni, G. B., Ashton, N. J., Blennow, K., Mattsson-Carlgren, N., Rosa-Neto, P., & Hansson, O. A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings, Nature Communications, March 14, 2024, Read More

Johnsson, M., Stenberg, Y. T., Farman, H. H., Blennow, K., Zetterberg, H., Malmeström, C., Sandgren, S., Rosenstein, I., Lycke, J., Axelsson, M., & Novakova, L. Serum neurofilament light for detecting disease activity in individual patients in multiple sclerosis: A 48-week prospective single-center study, Multiple Sclerosis, March 13, 2024, Read More

Nilsson, J., Pichet Binette, A., Palmqvist, S., Brum, W. S., Janelidze, S., Ashton, N. J., Spotorno, N., Stomrud, E., Gobom, J., Zetterberg, H., Brinkmalm, A., Blennow, K., & Hansson, O. Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases, Brain, February 7, 2024, Read More

Homann, J., Osburg, T., Ohlei, O., Dobricic, V., Deecke, L., Bos, I., Vandenberghe, R., Gabel, S., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., Popp, J., Clark, C., Peyratout, G., Martinez-Lage, P., Tainta, M., Dobson, R.J.B., Legido-Quigley, C., Sleegers, K., Van Broeckhoven, C., Wittig, M., Franke, A., Lill, C.M., Blennow, K., Zetterberg, H., Lovestone, S., Streffer, J., Kate, M., Vos, S. J. B., Barkhof, F., Visser, P. J., & Bertram, L. Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset, Frontiers in Aging Neuroscience, March 21, 2022, Read More

Van Egroo, M., Riphagen, J. M., Ashton, N. J., Janelidze, S., Sperling, R. A., Johnson, K. A., Yang, H. S., Bennett, D. A., Blennow, K., Hansson, O., Zetterberg, H., & Jacobs, H. I. L. Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau, Molecular Psychiatry, April 5, 2023, Read More

Hansson, O., Blennow, K., Zetterberg, H., & Dage, J. Blood biomarkers for Alzheimer’s disease in clinical practice and trials, Nature Aging, May 18, 2023, Read More

Suárez-Calvet, M., Kleinberger, G., Araque Caballero, M. Á., Brendel, M., Rominger, A., Alcolea, D., Fortea, J., Lleó, A., Blesa, R., Gispert, J. D., Sánchez-Valle, R., Antonell, A., Rami, L., Molinuevo, J. L., Brosseron, F., Traschütz, A., Heneka, M. T., Struyfs, H., Engelborghs, S., Sleegers, K., Van Broeckhove, C., Zetterberg, H., Nellgard, B., Blennow, K., Crispin, A., Ewers, M., & Haass, C. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers, EMBO Molecular Medicine, March 3, 2016, Read More

Michno, W., Stringer, K. M., Enzlein, T., Passarelli, M. K., Escrig, S., Vitanova, K., Wood, J., Blennow, K., Zetterberg, H., Meibom, A., Hopf, C., Edwards, F. A., & Hanrieder, J. Following spatial Aβ aggregation dynamics in evolving Alzheimer’s disease pathology by imaging stable isotope labeling kinetics, Science Advances, June 16, 2021, Read More

Wilson, D. M., 3rd, Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. Hallmarks of neurodegenerative diseases, Cell, February 16, 2023, Read More

Huber, H., Blennow, K., Zetterberg, H., Boada, M., Jeromin, A., Weninger, H., Nuñez-Llaves, R., Aguilera, N., Ramis, M., Simrén, J., Nilsson, J., Lantero-Rodriguez, J., Orellana, A., García-Gutiérrez, F., Morató, X., Ashton, N. J., & Montoliu-Gaya, L. Biomarkers of Alzheimer’s disease and neurodegeneration in dried blood spots-A new collection method for remote settings, Alzheimer's & Dementia, January 29, 2024, Read More

Gobom, J., Brinkmalm, A., Brinkmalm, G., Blennow, K., & Zetterberg, H. Alzheimer’s disease biomarker analysis using targeted mass spectrometry, Molecular & Cellular Proteomics, January 20, 2024, Read More

Brum, W. S., Docherty, K. F., Ashton, N. J., Zetterberg, H., Hansson, O., McMurray, J. J. V., & Blennow, K. Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers: A Secondary Analysis of a Randomized Clinical Trial, JAMA Neurology, December 18, 2023, Read More

Neumann, A., Ohlei, O., Küçükali, F., Bos, I. J., Timsina, J., Vos, S., Prokopenko, D., Tijms, B. M., Andreasson, U., Blennow, K., Vandenberghe, R., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., … EMIF-AD & ADNI study group Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning, Genome Medicine, October 4, 2023, Read More