These projects were made possible from Cure Alzheimer's Fund support.
Project Description | Researchers | Funding |
---|---|---|
Alzheimer’s Disease Tau Consortium: Deep Mass Spectrometry Profiling of Tau Aggregates in Alzheimer’s Disease and Other Tauopathies |
2022, 2024 $575,000 |
These published papers resulted from Cure Alzheimer’s Fund support.
1. Rea Reyes, R. E., Cody, K. A., Wilson, R. E., Zetterberg, H., Chin, N. A., Jonaitis, E. M., Bahr, M., Mandel, O., Wintlend, M., Bendlin, B. B., Okonkwo, O. C., Clark, L. R., Zammit, M., Asthana, S., Christian, B. T., Betthauser, T. J., Eisenmenger, L., Langhough, R. E., & Johnson, S. C. Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer’s disease, Alzheimer's & Dementia, November 19, 2024, Read More
Simrén, J., Ashton, N. J., Suárez-Calvet, M., & Zetterberg, H. Alzheimer’s disease—Biomarkers, clinical evaluation or both?, Journal of Neuropsychology, November 14, 2024, Read More
2. Therriault, J., Janelidze, S., Benedet, A. L., Ashton, N. J., Arranz Martínez, J., Gonzalez-Escalante, A., Bellaver, B., Alcolea, D., Vrillon, A., Karim, H., Mielke, M. M., … Petersen, R. C., … Zetterberg, H., … Hansson, O., & Rosa-Neto, P. Diagnosis of Alzheimer’s disease using plasma biomarkers adjusted to clinical probability, Nature Aging, November 12, 2024, Read More
Woo, M. S., Therriault, J., Jonaitis, E. M., Wilson, R., Langhough, R. E., Rahmouni, N., Benedet, A. L., Ashton, N. J., Tissot, C., Lantero-Rodriguez, J., Macedo, A. C., Servaes, S., Wang, Y. T., Arias, J. F., Hosseini, S. A., Betthauser, T. J., Lussier, F. Z., Hopewell, R., Triana-Baltzer, G., Kolb, H. C., … Rosa-Neto, P. Identification of late-stage tau accumulation using plasma phospho-tau217, eBioMedicine, November 4, 2024, Read More
Safransky, M., Groh, J. R., Blennow, K., Zetterberg, H., Tripodis, Y., Martin, B., Weller, J., Asken, B. M., Rabinovici, G. D., Qiu, W. W. Q., McKee, A. C., Stein, T. D., Mez, J., Henson, R. L., Long, J., Morris, J. C., Perrin, R. J., Schindler, S. E., & Alosco, M. L. Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease, Neurology, November 4, 2024, Read More
Olofsson, J., Bergström, S., Mravinacová, S., Kläppe, U., Öijerstedt, L., Zetterberg, H., Blennow, K., Ingre, C., Nilsson, P., & Månberg, A. Cerebrospinal fluid levels of NfM in relation to NfL and pNfH as prognostic markers in amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, November 2, 2024, Read More
Aye, S., Frisell, O., Zetterberg, H., Skillbäck, T. B., Kern, S., Eriksdotter, M., Aho, E., Xia, X., Winblad, B., Wimo, A., & Jönsson, L. Costs of Care in Relation to Alzheimer’s Disease Severity in Sweden: A National Registry-Based Cohort Study, PharmacoEconomics, November 1, 2024, Read More
Warmenhoven, N., Salvadó, G., Janelidze, S., Mattsson-Carlgren, N., Bali, D., Orduña Dolado, A., Kolb, H., Triana-Baltzer, G., Barthélemy, N. R., Schindler, S. E., Aschenbrenner, A. J., Raji, C. A., Benzinger, T. L. S., Morris, J. C., Ibanez, L., Timsina, J., Cruchaga, C., Bateman, R. J., Ashton, N., Arslan, B., … Hansson, O. A Comprehensive Head-to-Head Comparison of Key Plasma Phosphorylated Tau 217 Biomarker Tests, Brain, October 28, 2024, Read More
Al-Diwani, A., Provine, N. M., Murchison, A., Laban, R., Swann, O. J., Koychev, I., Sheerin, F., Da Mesquita, S., Heslegrave, A., Zetterberg, H., Klenerman, P., & Irani, S. R. Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes, Brain, October 21, 2024, Read More
Götze, K., Vrillon, A., Dumurgier, J., Indart, S., Sanchez-Ortiz, M., Slimi, H., Raynaud-Simon, A., Cognat, E., Martinet, M., Zetterberg, H., Blennow, K., Hourrègue, C., Bouaziz-Amar, E., Paquet, C., & Lilamand, M. Plasma neurofilament light chain as prognostic marker of cognitive decline in neurodegenerative diseases, a clinical setting study, Alzheimer's Research & Therapy, October 19, 2024, Read More
Miner, A. E., Groh, J. R., Tripodis, Y., Adler, C. H., Balcer, L. J., Bernick, C., Zetterberg, H., Blennow, K., Peskind, E., Ashton, N. J., Gaudet, C. E., Martin, B., Palmisano, J. N., Banks, S. J., Barr, W. B., Wethe, J. V., Cantu, R. C., Dodick, D. W., Katz, D. I., Mez, J., … DIAGNOSE CTE Research Project Examination of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in former elite American football players, Alzheimer's & Dementia, October 1, 2024, Read More
Johansson, C., Thordardottir, S., Laffita-Mesa, J., Pannee, J., Rodriguez-Vieitez, E., Zetterberg, H., Blennow, K., & Graff, C. Gene-variant specific effects of plasma amyloid-β levels in Swedish autosomal dominant Alzheimer disease, Alzheimer's Research & Therapy, September 25, 2024, Read More
Leuzy, A., Heeman, F., Bosch, I., Lenér, F., Dottori, M., Quitz, K., Moscoso, A., Kern, S., Zetterberg, H., Blennow, K., & Schöll, M. REAL AD—Validation of a realistic screening approach for early Alzheimer’s disease, Alzheimer's & Dementia, September 23, 2024, Read More
Sandgren, S., Novakova, L., Nordin, A., Sabir, H., Axelsson, M., Malmeström, C., Zetterberg, H., & Lycke, J. The effect of alemtuzumab on neurodegeneration in relapsing-remitting multiple sclerosis: A five-year prospective mono-center study, Multiple Sclerosis and Related Disorders, September 13, 2024, Read More
Borda, M. G., Barreto, G. E., Baldera, J. P., de Lucia, C., Khalifa, K., Bergland, A. K., Pola, I., Botero-Rodríguez, F., Siow, R. C., Kivipelto, M., Zetterberg, H., Ashton, N. J., Ballard, C., Aarsland, D., & NJ FINGER A randomized, placebo-controlled trial of purified anthocyanins on cognitive function in individuals at elevated risk for dementia: Analysis of inflammatory biomarkers toward personalized interventions, Experimental Gerontology, September 9, 2024, Read More
Li, Y., Luo, L., Senicar, L., Asrosa, R., Kizilates, B., Xing, K., Torres, E., Xu, L., Li, D., Graham, N., Heslegrave, A., Zetterberg, H., Sharp, D. J., & Li, B. An Ultrasensitive Molecularly Imprinted Point-Of-Care Electrochemical Sensor for Detection of Glial Fibrillary Acidic Protein, Advanced Healthcare Materials, September 2, 2024, Read More
Koetsier, J., Cavill, R., Reijnders, R., Harvey, J., Homann, J., … Dobricic, V., … Scheltens, P., … Zetterberg, H., … Lill, C. L., Bertram, L., … Pishva, E. Blood-based multivariate methylation risk score for cognitive impairment and dementia, Alzheimer's & Dementia, August 28, 2024, Read More
Quaresima, V., Pilotto, A., Trasciatti, C., Tolassi, C., Parigi, M., Bertoli, D., Mordenti, C., Galli, A., Rizzardi, A., Caratozzolo, S., Benussi, A., Ashton, N. J., Blennow, K., Zetterberg, H., Giliani, S., Brugnoni, D., & Padovani, A. Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA, Neurology of Aging, August 28, 2024, Read More
Quaresima, V., Pilotto, A., Trasciatti, C., Tolassi, C., Parigi, M., Bertoli, D., Mordenti, C., Galli, A., Rizzardi, A., Caratozzolo, S., Benussi, A., Ashton, N. J., Blennow, K., Zetterberg, H., Giliani, S., Brugnoni, D., & Padovani, A. Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA, Neurobiology of Aging, August 22, 2024, Read More
Di Filippo, M., Gaetani, L., Centonze, D., Hegen, H., Kuhle, J., Teunissen, C. E., Tintoré, M., Villar, L. M., Willemse, E. A. J., Zetterberg, H., & Parnetti, L. Fluid biomarkers in multiple sclerosis: from current to future applications, The Lancet Regional Health Europe, August 22, 2024, Read More
Malpetti, M., Swann, P., Tsvetanov, K. A., Chouliaras, L., Strauss, A., Chikaura, T., Murley, A. G., Ashton, N. J., Barker, P., Jones, P. S., Fryer, T. D., Hong, Y. T., Cope, T. E., Savulich, G., Street, D., Bevan-Jones, W. R., Rittman, T., Blennow, K., Zetterberg, H., Aigbirhio, F. I., … Rowe, J. B. Blood inflammation relates to neuroinflammation and survival in frontotemporal lobar degeneration, Brain, August 19, 2024, Read More
Zhang, Z., Xue, P., Bendlin, B. B., Zetterberg, H., De Felice, F., Tan, X., & Benedict, C. Melatonin: A potential nighttime guardian against Alzheimer’s, Molecular Psychiatry, August 11, 2024, Read More
Emeršič, A., Karikari, T. K., Kac, P. R., Gonzalez-Ortiz, F., Dulewicz, M., Ashton, N. J., Brecl Jakob, G., Horvat Ledinek, A., Hanrieder, J., Zetterberg, H., Rot, U., Čučnik, S., & Blennow, K. Biomarkers of tau phosphorylation state are associated with the clinical course of multiple sclerosis, Multiple sclerosis and related disorders, August 5, 2024, Read More
Ivanova, K., Zolovs, M., Blennow, K., Zetterberg, H., Kurjāne, N., & Ķēniņa, V. Polyneuropathy in systemic sclerosis: exploring the causes and biomarkers, Frontiers in Medicine, August 1, 2024, Read More
Fernström, E., Jarfelt, M., Blomstrand, M., Lannering, B., Axelsson, M., Wasling, P., Björk-Eriksson, T., Zetterberg, H., & Kalm, M. CSF biomarkers of neurotoxicity in childhood cancer survivors after cranial radiotherapy or surgery, Annals of Clinical and Translational Neurology, July 19, 2024, Read More
Lantero-Rodriguez, J., Camporesi, E., Montoliu-Gaya, L., Gobom, J., Piotrowska, D., Olsson, M., Burmann, I. M., Becker, B., Brinkmalm, A., Burmann, B. M., Perkinton, M., Ashton, N. J., Fox, N. C., Lashley, T., Zetterberg, H., Blennow, K., & Brinkmalm, G. Tau protein profiling in tauopathies: a human brain study, Molecular Neurodegeneration, July 19, 2024, Read More
Kasri, A., Camporesi, E., Gkanatsiou, E., Boluda, S., Brinkmalm, G., Stimmer, L., Ge, J., Hanrieder, J., Villain, N., Duyckaerts, C., Vermeiren, Y., Pape, S. E., Nicolas, G., Laquerrière, A., De Deyn, P. P., Wallon, D., Blennow, K., Strydom, A., Zetterberg, H., & Potier, M. C. Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome, Acta Neuropathologica, July 18, 2024, Read More
Doroszkiewicz, J., Kulczyńska-Przybik, A., Dulewicz, M., Mroczko, J., Borawska, R., Słowik, A., Zetterberg, H., Hanrieder, J., Blennow, K., & Mroczko, B. Associations between Microglia and Astrocytic Proteins and Tau Biomarkers across the Continuum of Alzheimer’s Disease, International Journal of Molecular Sciences, July 9, 2024, Read More
Delvenne, A., Gobom, J., Schindler, S. E., Kate, M. T., Reus, L. M., Dobricic, V., Tijms, B. M., Benzinger, T. L. S., Cruchaga, C., ... Bertram, L., … Zetterberg, H., ... Vos, S. J. B. CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer’s disease, Alzheimer's & Dementia, July 6, 2024, Read More
Zarkali, A., Thomas, G. E. C., Zetterberg, H., & Weil, R. S. Neuroimaging and fluid biomarkers in Parkinson’s disease in an era of targeted interventions, Nature Communications, July 5, 2024, Read More
Du, L., Langhough, R. E., Wilson, R. E., Reyes, R. E. R., Hermann, B. P., Jonaitis, E. M., Betthauser, T. J., Chin, N. A., Christian, B., Chaby, L., Jeromin, A., Molfetta, G. D., Brum, W. S., Arslan, B., Ashton, N., Blennow, K., Zetterberg, H., & Johnson, S. C. Longitudinal plasma phosphorylated-tau217 and other related biomarkers in a non-demented Alzheimer’s risk-enhanced sample, Alzheimer's & Dementia, July 5, 2024, Read More
Andriuta, D., Ottoy, J., Ruthirakuhan, M., Feliciano, G., Dilliott, A. A., … Zetterberg, H., ... ONDRI Investigators Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases, Alzheimer's & Dementia, July 4, 2024, Read More
Peretti, D. E., Boccalini, C., Ribaldi, F., Scheffler, M., Marizzoni, M., Ashton, N. J., Zetterberg, H., Blennow, K., Frisoni, G. B., & Garibotto, V. Association of glial fibrillary acid protein, Alzheimer’s disease pathology and cognitive decline, Brain, June 28, 2024, Read More
Orduña Dolado, A., Stomrud, E., Ashton, N. J., Nilsson, J., Quijano-Rubio, C., Jethwa, A., Brum, W. S., Brinkmalm Westman, A., Zetterberg, H., Blennow, K., Janelidze, S., & Hansson, O. Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers, Alzheimer's Research & Therapy, June 22, 2024, Read More
Beckers, E., Van Egroo, M., Ashton, N. J., Blennow, K., Vandewalle, G., Zetterberg, H., Poser, B. A., & Jacobs, H. I. L. Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study, Cerebral Cortex, 6/21/2024, Read More
Princen, K., Van Dooren, T., van Gorsel, M., Louros, N., Yang, X., … Zetterberg, H., ... Griffioen, G. Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer’s disease, Science, May 31, 2024, Read More
De Meyer, S., Schaeverbeke, J. M., Luckett, E. S., Reinartz, M., Blujdea, E. R., Cleynen, I., Dupont, P., Van Laere, K., Vanbrabant, J., Stoops, E., Vanmechelen, E., di Molfetta, G., Zetterberg, H., Ashton, N. J., Teunissen, C. E., Poesen, K., & Vandenberghe, R. Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET, Brain Communications, May 23, 2024, Read More
Jacobs, T., Jacobson, S. R., Fortea, J., Berger, J. S., Vedvyas, A., Marsh, K., He, T., Gutierrez-Jimenez, E., Fillmore, N. R., Gonzalez, M., Figueredo, L., Gaggi, N. L., Plaska, C. R., Pomara, N., Blessing, E., Betensky, R., Rusinek, H., Zetterberg, H., Blennow, K., Glodzik, L., … Alzheimer’s Disease Neuroimaging Initiative The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people, Immunity & Ageing, May 17, 2024, Read More
Gard, A., Kornaropoulos, E. N., Portonova Wernersson, M., Rorsman, I., Blennow, K., Zetterberg, H., Tegner, Y., De Maio, A., Markenroth Bloch, K., Björkman-Burtscher, I., Pessah-Rasmussen, H., Nilsson, M., & Marklund, N. Widespread White Matter Abnormalities in Concussed Athletes Detected by 7T Diffusion Magnetic Resonance Imaging, Journal of Neurotrauma, May 3, 2024, Read More
Gadd, G., Åberg, D., Wall, A., Zetterberg, H., Blennow, K., Jood, K., Jern, C., Isgaard, J., Svensson, J., & Åberg, N. D. Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome-The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1, International Journal of Molecular Sciences, April 30, 2024, Read More
Fruhwürth, S., Zetterberg, H., & Paludan, S. R. Microglia and amyloid plaque formation in Alzheimer’s disease – Evidence, possible mechanisms, and future challenges, Journal of Neuroinflammation, April 4, 2024, Read More
Brum, W. S., Cullen, N. C., Therriault, J., Janelidze, S., Rahmouni, N., Stevenson, J., Servaes, S., Benedet, A. L., Zimmer, E. R., Stomrud, E., Palmqvist, S., Zetterberg, H., Frisoni, G. B., Ashton, N. J., Blennow, K., Mattsson-Carlgren, N., Rosa-Neto, P., & Hansson, O. A blood-based biomarker workflow for optimal tau-PET referral in memory clinic settings, Nature Communications, March 14, 2024, Read More
Johnsson, M., Stenberg, Y. T., Farman, H. H., Blennow, K., Zetterberg, H., Malmeström, C., Sandgren, S., Rosenstein, I., Lycke, J., Axelsson, M., & Novakova, L. Serum neurofilament light for detecting disease activity in individual patients in multiple sclerosis: A 48-week prospective single-center study, Multiple Sclerosis, March 13, 2024, Read More
Nilsson, J., Pichet Binette, A., Palmqvist, S., Brum, W. S., Janelidze, S., Ashton, N. J., Spotorno, N., Stomrud, E., Gobom, J., Zetterberg, H., Brinkmalm, A., Blennow, K., & Hansson, O. Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases, Brain, February 7, 2024, Read More
Homann, J., Osburg, T., Ohlei, O., Dobricic, V., Deecke, L., Bos, I., Vandenberghe, R., Gabel, S., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., Popp, J., Clark, C., Peyratout, G., Martinez-Lage, P., Tainta, M., Dobson, R.J.B., Legido-Quigley, C., Sleegers, K., Van Broeckhoven, C., Wittig, M., Franke, A., Lill, C.M., Blennow, K., Zetterberg, H., Lovestone, S., Streffer, J., Kate, M., Vos, S. J. B., Barkhof, F., Visser, P. J., & Bertram, L. Genome-Wide Association Study of Alzheimer’s Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer’s Disease Multimodal Biomarker Discovery Dataset, Frontiers in Aging Neuroscience, March 21, 2022, Read More
Van Egroo, M., Riphagen, J. M., Ashton, N. J., Janelidze, S., Sperling, R. A., Johnson, K. A., Yang, H. S., Bennett, D. A., Blennow, K., Hansson, O., Zetterberg, H., & Jacobs, H. I. L. Ultra-high field imaging, plasma markers and autopsy data uncover a specific rostral locus coeruleus vulnerability to hyperphosphorylated tau, Molecular Psychiatry, April 5, 2023, Read More
Hansson, O., Blennow, K., Zetterberg, H., & Dage, J. Blood biomarkers for Alzheimer’s disease in clinical practice and trials, Nature Aging, May 18, 2023, Read More
Suárez-Calvet, M., Kleinberger, G., Araque Caballero, M. Á., Brendel, M., Rominger, A., Alcolea, D., Fortea, J., Lleó, A., Blesa, R., Gispert, J. D., Sánchez-Valle, R., Antonell, A., Rami, L., Molinuevo, J. L., Brosseron, F., Traschütz, A., Heneka, M. T., Struyfs, H., Engelborghs, S., Sleegers, K., Van Broeckhove, C., Zetterberg, H., Nellgard, B., Blennow, K., Crispin, A., Ewers, M., & Haass, C. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers, EMBO Molecular Medicine, March 3, 2016, Read More
Michno, W., Stringer, K. M., Enzlein, T., Passarelli, M. K., Escrig, S., Vitanova, K., Wood, J., Blennow, K., Zetterberg, H., Meibom, A., Hopf, C., Edwards, F. A., & Hanrieder, J. Following spatial Aβ aggregation dynamics in evolving Alzheimer’s disease pathology by imaging stable isotope labeling kinetics, Science Advances, June 16, 2021, Read More
Wilson, D. M., 3rd, Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. Hallmarks of neurodegenerative diseases, Cell, February 16, 2023, Read More
Huber, H., Blennow, K., Zetterberg, H., Boada, M., Jeromin, A., Weninger, H., Nuñez-Llaves, R., Aguilera, N., Ramis, M., Simrén, J., Nilsson, J., Lantero-Rodriguez, J., Orellana, A., García-Gutiérrez, F., Morató, X., Ashton, N. J., & Montoliu-Gaya, L. Biomarkers of Alzheimer’s disease and neurodegeneration in dried blood spots-A new collection method for remote settings, Alzheimer's & Dementia, January 29, 2024, Read More
Gobom, J., Brinkmalm, A., Brinkmalm, G., Blennow, K., & Zetterberg, H. Alzheimer’s disease biomarker analysis using targeted mass spectrometry, Molecular & Cellular Proteomics, January 20, 2024, Read More
Brum, W. S., Docherty, K. F., Ashton, N. J., Zetterberg, H., Hansson, O., McMurray, J. J. V., & Blennow, K. Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers: A Secondary Analysis of a Randomized Clinical Trial, JAMA Neurology, December 18, 2023, Read More
Neumann, A., Ohlei, O., Küçükali, F., Bos, I. J., Timsina, J., Vos, S., Prokopenko, D., Tijms, B. M., Andreasson, U., Blennow, K., Vandenberghe, R., Scheltens, P., Teunissen, C. E., Engelborghs, S., Frisoni, G. B., Blin, O., Richardson, J. C., Bordet, R., Lleó, A., Alcolea, D., … EMIF-AD & ADNI study group Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning, Genome Medicine, October 4, 2023, Read More