PICALM Gene Therapy and Drug Screening for Amyloid Beta Clearance (Year 3)

PICALM is highly associated with late-onset AD based on genome-wide association studies. PICALM facilitates clathrin-mediated endocytosis and regulates the internalization and intracellular trafficking of cell surface receptors. Its N-terminus contains an epsin NH2-terminal homology domain for phosphatidylinositol-4,5-bisphosphate binding, which allows PICALM to sense membrane curvatures and regulate the size of ...

June 19, 2018

Berislav Zlokovic

Targeting Tau’s Tangles

Finding the correct arsenal for preventing plaques, tangle formation and neuroinflammation is the holy grail for scientists studying Alzheimer’s disease. All three join together to disrupt communication between neurons—leading to an eventual complete loss of autonomy.     The Newfound Focus on Tau Plaques are composed of amyloid protein and have been the major ...

November 9, 2017

Patricia Anne “Patty” Ciaschi

Patricia Anne “Patty” Ciaschi, 80, died peacefully at home in Ithaca on July 15, 2022. She was born on December 2, 1941, to Albert E. II and Vivian Greene of Ithaca, NY. In addition to her parents, Patricia was pre-deceased by her parents-in-law Robert and Connie O’Neil; her sister Janet ...

September 1, 2022

The Still Alice Project

Above: Clip from the Still Alice film. Still Alice is a New York Times bestselling novel by author Lisa Genova. The book follows Alice Howland, a Harvard professor who is diagnosed with young onset Alzheimer’s disease. While Alice once placed her worth and identity in her celebrated and respected academic life, now ...

July 7, 2014

Study Sheds More Light on Abeta’s Impact on Alzheimer’s — Research Funded in Part by Cure Alzheimer’s Fund

A new study, funded in part by Cure Alzheimer’s Fund, is shedding more light on amyloid beta’s (Aβ) impact on Alzheimer’s disease. If you regularly read our blog, you know that studies suggest that Aβ contributes to the early stages of Alzheimer’s (Aβ plays a key role in early synaptic failure ...

January 4, 2010

Project for Awesome: Cure Alzheimer’s Fund

High school students Anjali Chakradhar, Sathya Edamadaka and Emily Huang created this video about Cure Alzheimer’s Fund as part of 2015’s Project For Awesome campaign. We’re so thankful to them for helping to raise awareness about this important cause.

December 14, 2015

Climber Reaches the Halfway Point for Cure Alzheimer’s Fund

Bobby Zerwick left his comfortable home in Pennsylvania last March 10 with two goals: To hike the entire Appalachian Trail this summer and to raise much-needed research funds to find a cure for Alzheimer’s disease. The hike started at Springer Mountain in Georgia, and Bobby will hike north for a ...

June 4, 2012

Support Cure Alzheimer’s Fund in the Inaugural “Running 4 Answers” 4-Mile Race!

For far too many of us, Alzheimer’s is a cause that is deeply personal. One such woman is Carolyn Mastrangelo. Carolyn’s mother has suffered from early onset Alzheimer’s for over 10 years. A personal trainer and avid runner, Carolyn wanted to incorporate her love of running and apply it to raising ...

January 8, 2010

Study Sheds More Light on Abeta’s Impact on Alzheimer’s — Research Funded in Part by Cure Alzheimer’s Fund

A new study, funded in part by Cure Alzheimer’s Fund, is shedding more light on amyloid beta’s (Aβ) impact on Alzheimer’s disease. If you regularly read our blog, you know that studies suggest that Aβ contributes to the early stages of Alzheimer’s (Aβ plays a key role in early synaptic failure ...

January 4, 2010

Federal Funding to Support Cure Alzheimer’s Fund in 2010!

Earlier this week, President Obama signed a bill into law that includes $150,000 in federal funding to support our search for a cure! Submitted as part of the Consolidated Appropriations Act of 2010 by Sens. John Kerry and Paul Kirk, and Rep. Ed Markey, the funding will support the Alzheimer’s Genome ...

December 31, 2009