Landmark Study Evaluates Racial Disparities in Alzheimer’s Disease Biomarkers

To date, few studies have been conducted that examine racial differences in Alzheimer’s disease biomarkers despite the fact that African Americans may have more than 2-fold increased risk for Alzheimer’s dementia than their white counterparts. A study published on this week in JAMA Neurology by Dr. John Morris, Dr. Krista ...

March 14, 2019

Distinct Cytokine Profiles in human brains resilient to Alzheimer’s pathology

October 15, 2018

John C. Morris, Krista L. Moulder, Ronald C. Petersen, Teresa Gomez-Isla, William Klunk

Lance Johnson

Dr. Johnson is an Assistant Professor in the Department of Physiology and Sanders Brown Center of Aging at the University of Kentucky. Research in Dr. Johnson’s lab is dedicated to understanding the role of the  Alzheimer’s disease risk factor Apolipoprotein E (APOE) in cerebral metabolism. With a special focus on ...

January 26, 2022

Lance Johnson

Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light

January 30, 2024

John C. Morris, Krista L. Moulder, Randall J. Bateman

African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants

January 30, 2024

David Holtzman, John C. Morris, Krista L. Moulder

Lars Bertram

Lars Bertram graduated from medical school at Ruhr University Bochum, Germany, in 1997 and began his clinical training at the Alzheimer Centre of the Klinikum rechts der Isar in Munich. In 1999, he joined the Genetics and Aging Research Unit at Massachusetts General Hospital (MGH), where he was appointed to ...

February 17, 2018

Lars Bertram

DECREASED LEVELS OF TREM2 LEADS TO IMPAIRED FUNCTION OF THE MICROGLIA, PART OF THE BRAIN’S IMMUNE DEFENSE SYSTEM

Individuals who inherit a variant of the TREM2 gene have up to a 4x increase in their risk for Alzheimer’s disease. A paper published in Nature Neuroscience with funding from Cure Alzheimer’s Fund offers insights into why individuals who carry this genetic mutation have an increased risk of Alzheimer’s disease ...

June 24, 2019

Living With Alzheimer’s: Four Short Films

When author David Shenk wrote The Forgetting, Alzheimer’s: Portrait of an Epidemic, he gave us the big picture of Alzheimer’s disease. His latest project, “Living With Alzheimer’s”, a series of four short films created with funding from the MetLife Foundation and in partnership with Cure Alzheimer’s Fund, brings us to the ...

September 13, 2013

The APOE Mimetic Therapeutic Peptide CN-105 Attenuates AD Pathology and Improves Functional Outcomes in a Murine Model of Alzheimer’s Disease

2019 Inflammation plays an important role in the progression of Alzheimer’s disease. Several genetic factors modulate inflammation and have the potential to provide insight into novel treatment strategies. Modifying brain inflammatory responses is one important mechanism by which apolipoprotein E protein isoforms may modify susceptibility and progression of AD. The APOEgene ...

January 4, 2017

Daniel Laskowitz

Mechanisms By Which the Gut Microbiome Influences Amyloid Deposition and Neuroinflammation in Mouse Models of Alzheimer’s Disease

In our earlier proposal, we tested the hypothesis that the composition of the intestinal microbiome might play a key role in modulating neuroinflammation that, in turn, influences Abeta deposition. We have demonstrated that long-term treatment with an antibiotic (ABX) cocktail does not alter total bacterial abundance in either the cecum ...

July 5, 2016

Sangram S. Sisodia