SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers

January 30, 2024

George S. Bloom

The retromer complex and sorting nexins in neurodegenerative diseases

January 30, 2024

Huaxi Xu

Role of common and rare APP DNA sequence variants in Alzheimer’s Disease

January 30, 2024

Christoph Lange, Lars Bertram, Rudolph Tanzi

Alzheimer’s and Antidepressants: Dr. Rudy Tanzi Comments

Segment on Alzheimer’s disease begins at 3:10. Last week, many news stories broke about a recent study suggesting levels of amyloid, the sticky substance that builds up in the brain of Alzheimer’s patients, may be lowered by the antidepressant Celexa. Dr. Rudy Tanzi, of Harvard Medical School/Massachusetts General Hospital and chair ...

May 19, 2014

Combined treatment with phenolics (-)-epigallocatecin-3 gallate and ferulic acid improves cognition and reduces Alzhiemer-like pathology in mice

January 30, 2024

Terrence Town

Extracellular tau oligomers induce invasion of endogenous tau into the somatodendritic compartment and axonal transport dysfunction

January 30, 2024

George S. Bloom

Developing the “Next Generation: of genetic association databases for complex diseases

July 12, 2012

Lars Bertram

Microbial Immuno-Communication in Neurodegenerative Diseases

January 30, 2024

Sangram S. Sisodia

Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms

March 19, 2024

Oskar Hansson

Regional Variability of Pathology-Associated Properties of Tau in Posterior Cortical Atrophy

Alzheimer’s disease (AD) typically manifests first with short-term memory problems. However, in less common circumstances, AD can start with cognitive symptoms other than memory deficits. Posterior cortical atrophy (PCA) is a less common form of AD that starts with changes in visual perception and/or spatial awareness rather than memory loss. ...

May 9, 2022

Bradley T. Hyman, John R. Dickson