The Role of Impaired Synaptic Vesicle Machinery Proteostasis in Alzheimer’s Disease Pathogenesis


Despite the tremendous biomedical research efforts of the past century, Alzheimer’s disease (AD) remains an incurable form of dementia that affects more than 44 million people worldwide. While it is known that the most prevalent early symptom of AD is memory impairment, a precise understanding of the molecules and mechanisms that underlie memory loss remain unknown. This project investigates the possibility that synapse malfunction and memory failure in AD may be caused, in part, by impaired degradation of the synaptic vesicle machinery. Synaptic vesicles found inside the membrane of a cell release neurotransmitters to facilitate communication between neurons. Lack of properly functioning synaptic vesicle machinery over months and years is expected to drive a rundown of neurotransmitter release, eventually halting synaptic communication and contributing to progressive cognitive decline.


Funding to Date



Foundational Genetics, Pathological Pathways and Systems


Jeffrey Savas, Ph.D.