Brain Entry and Exit Consortium: Does Subarachnoid Lymphatic-Like Membrane Failure Compromise Glymphatic Clearance in Alzheimer’s Disease?

2024

This proposal will test whether age-dependent atrophy and loss of barrier function of the recently discovered meningeal membrane named subarachnoid lymphatic-like membrane (SLYM) contributes to recirculation of cerebrospinal fluid and amyloid beta accumulation. 


Funding to Date

$287,500

Focus

Studies of Alternative Neurodegenerative Pathways, Translational

Researchers

Maiken Nedergaard, M.D., D.M.Sc.