Benjamin Wolozin, M.D. Ph.D.

Dr. Wolozin’s research investigates the pathophysiology of neurodegenerative diseases. His research investigates the mechanisms by which genes cause dementia (Alzheimer’s disease and Frontotemporal Dementia) and movement disorders (Parkinson’s disease and Amyotrophic Lateral Sclerosis). The group has recently focused on understanding the role of RNA binding proteins in neurodegenerative diseases, focusing on how the regulated protein aggregation of RNA binding proteins contributes pathological aggregation and neuronal dysfunction.  The laboratory uses a variety of models to study disease, including cell culture (primary neurons, iPSCs and cell lines), C. elegans, transgenic mice and pathological human tissues.  The laboratory also uses these approaches for drug discovery seeking to identify novel compounds for therapy and diagnosis of neurodegenerative diseases. Dr. Wolozin also has experience doing epidemiological research, including studies highlighting the potential value of statins and of angiotensin receptor blockers as therapy for dementia.

Dr. Wolozin graduated magna cum laude from Wesleyan University in Middletown, CT. He earned his M.D. and Ph.D. degrees from Albert Einstein College of Medicine, and did his postdoctoral fellowships at the National Institute of Mental Health.  He joined Loyola University Medical Center in 1996 moved to Boston University in 2004. Dr. Wolozin has received numerous awards for his research including the Donald B. Lindsley Prize, Society for Neuroscience, the A. E. Bennett Award from the Society for Biological Psychiatry, the Zenith Award from the Alzheimer Association, the Graduate Faculty of the Year Award from Loyola University Medical Center and the Collaborator of the Year from Boston University Evans Center.   He has served on numerous editorial boards, and currently chair of the NIH CMND study section.  Dr. Wolozin has published over 140 papers or book chapters, and been awarded 4 patents.


Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E.A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin Interaction of tau with the RNA-binding Protein TIA1 Regulates tau Pathophysiology and Toxicity, Cell Reports, May 2016, Read More