Stephen T.C. Wong, Ph.D.

John S. Dunn, Sr. Presidential Distinguished Endowed Chair in Biomedical Engineering; Associate Director of Shared Resources, Houston Methodist Neal Cancer Center; Chief Research Information Officer, Houston Methodist Hospital; Founding Director, the T. T. & W. F. Chao Center for BRAIN; Houston Methodist Research Institute; Professor of Radiology, Neurosciences, Pathology and Laboratory Medicine, Weill Cornell Medicine

Dr. Stephen Wong is the Director of the Ting Tsung and Wei Fong Chao Center for Bioinformatics Research and Imaging for Neuroscience (BRAIN) and the Chair of Systems Medicine and Bioengineering Department, Houston Methodist Research Institute.

Dr. Wong is a specialist in medical imaging and systems biology and their applications to neurological disease. He is a hybrid scientist with career highlights including: leading teams that automated the world’s first VLSI 1MB computer memory production (AT&T) and optoelectronics devices production (Hewlett Packard), developing the world’s largest on-line brokerage trading system (Charles Schwab), contributing to the world’s first hospital-wide PACS in academic medical centers (UCSF) and the 90’s NIH Human Brain Project Program, and directing product development and implementing one of the largest radiology information systems in Europe (Assistance Publique-Hopitaux de Paris, France) at Philips Healthcare, Royal Philips Electronics. While on the faculty at Harvard Medical School, Dr. Wong founded the Harvard Center for Neurodegeneration and Repair’s Center for Bioinformatics, and the Functional and Molecular Imaging Center, including the creation of the first cyclotron facilities and preclinical optical imaging laboratory, at Brigham and Women’s Hospital, Partner Healthcare.

Dr. Wong has dedicated the second part of his career to solving disease problems, applying engineering principles to the identification of new disease treatments. He has broad, interdisciplinary research experience in multi-scale imaging, biomedical informatics, computer science, and molecular and cellular biology to identify new drug targets, biomarkers, and signaling crosstalk for fast track drug repositioning and discovery. His ability to integrate an extremely diverse skillset and domain knowledge uniquely situates him to combat complex diseases like Alzheimer’s.

At Houston Methodist, work in the PI’s lab has focused on generation of disruptive technologies that seek to make disease cures faster and more efficient. This AD work has focused on two primary objectives: (1) modeling phenotypic data to deliver a comprehensive understanding of the wide array of genetic and molecular interactions involved in normal brain function and neurodegeneration and (2) fast, efficient identification of known or shelved drugs and drug combinations for treatment.

To learn more, visit the Systems Medicine and Bioengineering Department website and follow Houston Methodist Research Institute on social media @HMethodistMD

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Li, X., Wang, L., Cykowski, M., He, T., Liu, T., Chakranarayan, J., Rivera, A., Zhao, H., Powell, S., Xia, W., & Wong, S. T. C. OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages, eBioMedicine, January 10, 2020, Read More

Yin, Z., & Wong, S. T. C. Converging multi-modality datasets to build efficient drug repositioning pipelines against Alzheimer’s disease and related dementias, Medical Reviews, February 14, 2022, Read More