Cynthia A. Lemere, Ph.D.

Scientist, Ann Romney Center for Neurologic Diseases, Brigham & Women’s Hospital; Associate Professor of Neurology, Harvard Medical School in Boston

Cynthia A. Lemere, Ph.D., is a Scientist in the Ann Romney Center for Neurologic Diseases at Brigham & Women’s Hospital and Associate Professor of Neurology at Harvard Medical School in Boston. Dr. Lemere’s research focuses on understanding and using the immune system therapeutically to prevent and treat Alzheimer’s disease. Dr. Lemere earned a bachelor’s degree in psychology and education from Mount Holyoke College and a master’s in neurobiology from SUNY Albany. Dr. Lemere examined Alzheimer’s-related brain changes in people with Down syndrome in the Selkoe Laboratory at Brigham and Women’s Hospital (BWH) while pursuing her doctorate in Pathology at Boston University School of Medicine. After receiving her Ph.D., she remained at the BWH Ann Romney Center for Neurologic Diseases within the Department of Neurology where she is an associate professor. Her current research involves:

1. non-clinical studies of antibody treatments targeting a pathogenic form of amyloid-beta protein in Alzheimer’s disease;

2. the role of complement signaling in aging and Alzheimer’s disease; and

3. the effects of deep space galactic cosmic radiation on brain aging and the risk of Alzheimer’s disease in studies in mouse models and human neural cells in preparation for NASA’s first manned mission to Mars in the 2030s.

Her lab is funded by NIH and NASA. Dr. Lemere is a member and the past chair of the Alzheimer’s Association’s Medical and Scientific Advisory Group and a former member of the Association’s board of directors. She is a member of the Cure Alzheimer’s Fund Research Leadership Group. In addition, she serves as a scientific advisor for several foundations, conferences, and companies.


Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O’Loughlin, Yang Xu, Zain Fanek, David J. Greco, Scott T. Smith, George Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Zhiping Weng, Hao Chen, Emily Tjon, Fargol Mazaheri, Kristin Hartmann, Asaf Madi, Jason D. Ulrich, Markus Glatzel, Anna Worthmann, Joerg Heeren, Bogdan Budnik, Cynthia Lemere, Tsuneya Ikezu, Frank L. Heppner, Vladimir Litvak, David M. Holtzman, Hans Lassmann, Howard L. Weiner, Jordi Ochando, Christian Haass, Oleg Butovsky The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases, Immunity, 47(3), 19 Sep 2017, 566-581, Read More

Alexandra J. Mably, Daniel Kanmert, Jessica M. Mc Donald, Wen Liu, Barbara J. Caldarone, Cynthia A. Lemere, Brian O'Nuallain, Kenneth S. Kosik, Dominic M. Walsh Tau immunization: a cautionary tale?, Neurobiology of Aging, 36(3), March 2015, 1316–1332, Read More