Greg Lemke, Ph.D.

Professor Emeritus, Salk Institute for Biological Studies

Greg Lemke is the Françoise Gilot-Salk Professor at the Salk Institute. He is a leader in the molecular genetic analysis of receptor tyrosine kinases. He discovered important roles for ErbB receptors in cardiac and neural development, for EphA receptors in the topographic mapping of neuronal connections in the developing brain and, most notably, for TAM family receptors in immune regulation.

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Microglial TAM Receptors as Modulators of Alzheimer’s Pathology 2017 and 2018


Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Huang, Y., Happonen, K. E., Burrola, P. G., O'Connor, C., Hah, N., Huang, L., Nimmerjahn, A., & Lemke, G. Microglia use TAM receptors to detect and engulf amyloid β plaques, Nature Immunology, April 15, 2021, Read More

Lemke G. How macrophages deal with death, Nature Reviews Immunology, April 24, 2019, Read More

Huang, Y., & Lemke, G. Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling, Proceedings of the National Academy of Sciences of the United States of America, October 3, 2022, Read More

Huang, Y., & Lemke, G. Adaptable toolbox to characterize Alzheimer’s disease pathology in mouse models, STAR Protocols, December 16, 2022, Read More

Paolicelli, R. C., Sierra, A., Stevens, B., et al. Microglia states and nomenclature: A field at its crossroads, Neuron, November 2, 2022, Read More