Jorge Palop, PhD, is an Associate Investigator at the Gladstone Institute of Neurological Disease (GIND) and an Associate Professor of Neurology at the University of California, San Francisco (UCSF). He earned his PhD in Neuroscience from the University of Valencia in Spain and completed his postdoctoral training in Dr. Lennart Mucke’s laboratory at GIND. Dr. Palop’s research focuses on understanding the neural mechanisms underlying cognitive decline in Alzheimer’s disease (AD). He discovered that mouse models of Alzheimer’s disease (AD) develop aberrant patterns of neural network activity, including network hyperexcitability and brain oscillatory changes linked to inhibitory interneuron dysfunction. His current work aims to elucidate the role of inhibitory interneurons in AD pathogenesis and explore the therapeutic potential of interneuron-based interventions in AD, including cell-based therapies, small-molecule Nav1.1 enhancers, or AAV-driven optogenetic stimulations. The Palop lab is also developing artificial intelligence-based computer vision tools to detect subtle behavioral changes during the prodromal stages of AD progression.